Methods Totally 125 hypertension patients and 40 normal subjects (group N) were enrolled. According to Ganan classification, hypertension patients were classified into normal geometry (groups A, n=45), concentric remodeling (group B, n=25), concentric hypertrophy (group C, n=25) and eccentric hypertrophy (group D, n=30). Parameters of left ventricular systolic function, including global area strain (GAS), regional area strain (RAS) and left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), cardiac output (CO), ejection fraction (EF), spherical index (Spl), end-diastolic weight (EDMass) were analyzed.
Results There was no statistically significant difference among thegroups A, B, C, D, and N in left ventricular EDV, SV and CO (F=0.679, 3.829, 0.600, P>0.05). There were statistically significant differences among ESV, EF, Spl and EDMass (F=3.829, 6.596, 2.653, 6.596, P<0.05). There were statistically significant differences among ESV of group D and that of groups N, A, B and C (t=2.011, 2.244, 3.685 and 2.244, P<0.05). There was statistically significant difference among ESV of group B with that of group N (t=2.170, P<0.05). There were statistically significant differences among EF of group B with that of groups N, A and D (t=2.452, 3.514 and 2.452, P<0.05). There were statistically significant differences among EF of group D with that of groups N and C (t=2.849 and 3.486, P<0.05), There were statistically significant differences among SpI of group D with that of groups N, A, B and C (t=2.854, 2.941, 3.200 and 2.941, P<0.05). There were statistically significant differences among EDMass of group C with that of groups N and A (t=2.170 and 2.087, P<0.05). There were statistically significant differences among EDMass of group D with that of groups A, B and N (t=2.668, 2.081 and 3.762, P<0.05). There were statistically significant differences in GAS among groups A, B, C, D and group N (t=7.950, 7.361, 8.959 and 7.361, P<0.01), and the difference was more apparent with the increasing of left ventricular remodeling. There were statistically significant differences in the comparison of GAS in group D and groups A and B, respectively (t=3.332 and 2.102, P<0.05). There were statistically significant differences in the comparison of GAS in group A and group C (t=3.134, P<0.05). There were statistically significant differences in the comparison of group D and N in the segment of 1-17, respectively (t=2.967, 3.793, 4.896, 4.001, 2.375, 4.169, 4.077, 2.137, 4.652, 4.016, 5.230, 6.267, 5.735, 2.143, 2.353, 5.429 and 2.353, P<0.05). There were statistically significant differences in the comparison of groups A, B, C and group N, including basal anteroseptal, basal posteroseptal, basal anterolateral, mid anterolateral, apical anterior, apical lateral and apex (A-N: t=2.667, 3.084, 3.574, 4.771, 3.182, 4.806, 3.567, all P<0.05; B-N: t=2.702, 2.868, 2.179, 3.130, 3.302, 3.203, 3.093, all P<0.05; C-N: t=4.927, 5.600, 4.276, 6.577, 6.198, 5.190, 5.441, all P<0.05). There was no statistically significant difference in apical septal among the groups A, B, C and groups N (t=0.934, 1.562 and 0.934, P>0.05).