探讨应用超声向量血流成像（V Flow）技术评价健康成人股腘动脉不同节段壁剪切力（WSS）的可行性，并分析WSS的分布规律及影响因素。

选取2022年5月至2023年5月北京大学国际医院招募的健康成人志愿者101名（202条肢体），使用Mindray Resona7超声仪（配备V Flow软件，v2.5）测量股总动脉、股总动脉分叉处、股浅动脉近段、股浅动脉中段、股浅动脉远段及腘动脉的最大壁剪切力（WSS_max）和平均壁剪切力（WSS_mean），并同步测量各部位血流速度。采用线性混合模型分析不同节段WSS差异及其与血流速度的相关性，并分析性别、年龄、体质量指数及收缩压对WSS的影响。随机选取30名志愿者的动态图像，由2名医师独立测量，通过组内相关系数（ICC）和Bland-Altman分析评估观察者间一致性。

股总动脉分叉处WSS_max[（4.09±1.04）Pa]和WSS_mean[（0.69±0.25）Pa]均显著低于其相邻节段（P均＜0.001）。自股浅动脉近段至腘动脉WSS_max和WSS_mean呈逐渐减低趋势。WSS与血流速度呈显著正相关（WSS_max：r=0.660，P＜0.001；WSS_mean：r=0.705，P＜0.001）。年龄是WSS_mean的独立影响因素（F=10.197，P=0.002），随年龄增长WSS_mean呈下降趋势，年龄每增加1岁，WSS_mean降低0.005 Pa（95%CI：-0.008~-0.002）。观察者间一致性分析显示，WSS_max和WSS_mean的ICC值分别为0.918和0.880，Bland-Altman分析表明观察者间无显著系统性测量偏差。

超声V Flow技术测量下肢动脉WSS具有可行性，可无创、可靠地测量健康成人股腘动脉WSS。WSS在股总动脉分叉处显著低于相邻节段，且自股浅动脉近段至腘动脉呈逐渐下降趋势，符合血流动力学规律；WSS与血流速度呈显著正相关，并随年龄增长而降低。

To explore the feasibility of using ultrasound vector flow imaging (V Flow) technology to evaluate wall shear stress (WSS) across different segments of the femoral-popliteal arteries in healthy adults, and to analyze its distribution patterns and influencing factors.

A total of 101 healthy adult volunteers (202 limbs) recruited from Peking University International Hospital between May 2022 and May 2023 were included. Using a Mindray Resona7 ultrasound system equipped with V Flow software (v2.5), the maximum wall shear stress (WSS_max) and mean wall shear stress (WSS_mean) were measured in the common femoral artery, common femoral artery bifurcation, proximal superficial femoral artery, mid superficial femoral artery, distal superficial femoral artery, and popliteal artery. Blood flow velocity (T-Max) was simultaneously measured at each site. A linear mixed model was used to analyze differences in WSS across segments and its correlation with blood flow velocity, as well as to examine the effects of gender, age, body mass index, and systolic blood pressure on WSS. Images from 30 randomly selected volunteers were independently measured by two doctors, and inter-observer consistency was assessed using intraclass correlation coefficient (ICC) and Bland-Altman analysis.

Both WSS_max [(4.09±1.04) Pa] and WSS_mean [(0.69±0.25) Pa] at the common femoral artery bifurcation were significantly lower than those in adjacent segments (both P＜0.001). From the proximal superficial femoral artery to the popliteal artery, WSS_max and WSS_mean showed a gradually decreasing trend. WSS was significantly positively correlated with blood flow velocity (WSS_max: r=0.660, P＜0.001; WSS_mean: r=0.705, P＜0.001). Age was an independent influencing factor for WSS_mean (F=10.197, P=0.002), with WSS_mean decreasing as age increased. For every 1-year increase in age, WSS_mean decreased by 0.005 Pa (95% confidence interval: -0.008 to -0.002). Inter-observer consistency analysis showed ICC values of 0.918 for WSS_max and 0.880 for WSS_mean, and Bland-Altman analysis indicated no significant systematic measurement bias between observers.

Ultrasound V Flow technology can noninvasively and reliably measure WSS in the femoral-popliteal arteries of healthy adults. WSS is significantly lower at the common femoral artery bifurcation compared with adjacent segments, and shows a gradually decreasing trend from the proximal superficial femoral artery to the popliteal artery, consistent with hemodynamic principles. WSS is significantly positively correlated with blood flow velocity and decreases with advancing age.