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药物负荷超声心动图及新型腺苷类负荷药物的临床应用

  • 彭安庆 ,
  • 郑敏娟 , 2,
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  • 1.710021 西安医学院研究生部
  • 2.710032 西安,西京医院超声医学科
通信作者:郑敏娟,Email:

Copy editor: 汪荣

收稿日期: 2023-05-15

  网络出版日期: 2024-04-25

基金资助

陕西省国际科技合作计划重点项目(2022KWZ-19)

西安市科技计划项目(21YXYJ0105)

版权

未经授权,不得转载、摘编本刊文章,不得使用本刊的版式设计,除非特别声明,本刊刊出的所有文章不代表中华医学会和本刊编委会的观点。本刊为电子期刊,以网刊形式出版。

Clinical application of drug stress echocardiography and a novel A2A adenosine receptor agonist as a pharmacologic stressor

  • Anqing Peng ,
  • Meijuan Zheng ,
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Received date: 2023-05-15

  Online published: 2024-04-25

Copyright

Copyright by Chinese Medical Association No content published by the journals of Chinese Medical Association may be reproduced or abridged without authorization. Please do not use or copy the layout and design of the journals without permission. All articles published represent the opinions of the authors, and do not reflect the official policy of the Chinese Medical Association or the Editorial Board, unless this is clearly specified.

摘要

我国现有约3.3亿心血管疾病患者,每年约350万人死于心血管疾病,而其中因冠心病(coronary heart atherosclerotic disease,CHD)死亡的患者超过30%,CHD成为影响人口健康的重大疾病。负荷超声心动图是一种无创的超声检查方法,可检出静息状态下难以评估的心肌缺血,评价存活心肌、冠状动脉储备功能等,对CHD诊断具有不可替代的重要作用。腺苷是负荷超声最常用的药物之一,激动血管内皮细胞A2受体引起血管扩张从而达到心肌内血流量增加、心脏负荷增大的目的,但可能伴发的不良反应如支气管收缩、心脏房室传导阻滞等一定程度上限制了其应用。近年来,新出现的心肌负荷药物瑞加诺生注射液(Regadenoson)是选择性腺苷A2a受体激动剂,可选择性扩张冠状动脉,提高对心肌缺血及冠状动脉微血管疾病(coronary microvascular dysfunction,CMVD)的诊断率,为临床诊疗策略提供重要参考。与传统腺苷相比,其可扩张冠状动脉,而对支气管等其他部位无明显作用,不良反应小且操作简便,具有广阔的应用前景。本文将对药物负荷超声的机制及新型腺苷类负荷药物瑞加诺生负荷超声的临床应用做一综述。

本文引用格式

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