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Chinese Journal of Medical Ultrasound (Electronic Edition) >

2021 , Vol. 18 >Issue 03: 266 - 271

DOI: https://doi.org/10.3877/cma.j.issn.1672-6448.2021.03.005

Superficial Parts Ultrasound

Ultrasound characteristics of medullary thyroid carcinoma

  • Xin Liu ,
  • Qiaodan Zhu ,
  • Junping Liu ,
  • Dong Xu ,
  • Pintong Huang
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  • 1. Department of Ultrasound, the Second Affiliated Hospital of Zhejiang University, Hangzhou 310009, China; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, Department of Ultrasound, Zhejiang Cancer Hospital, Hangzhou 310022, China
    2. The Second Clinical Medical University of Zhejiang Chinese Medical Univercity, Hangzhou 310053, China
    3. Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, Department of Ultrasound, Zhejiang Cancer Hospital, Hangzhou 310022, China
    4. Department of Ultrasound, the Second Affiliated Hospital of Zhejiang University, Hangzhou 310009, China
Huang Pintong, Email:

Received date: 2020-10-15

  Online published: 2021-04-23

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Abstract

Objective

To analyze the ultrasound characteristics of medullary thyroid carcinoma (MTC), in order to provide a reference for the diagnosis and preoperative management of MTC.

Methods

Eighty-five MTC patients with complete ultrasound and clinical data were retrospectively selected from the Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) from October 2009 to February 2020, and 150 PTC patients were selected from October 2019 to February 2020 as a control group. All patients underwent surgical treatment at our hospital and were diagnosed by routine pathology after surgery. Preoperative serum calcitonin test results were collected. The t-test was used to compare the differences in age and nodule size between the two groups; the χ2 test was used to compare the differences in gender, edges, morphology, blood supply, and neck metastatic lymph nodes between the two groups. Factors with a statistically significant difference in univariate analysis were used for multivariate logistic regression analysis.

Results

Approximately 97.0% (65/67) of MTC patients had increased serum calcitonin to varying degrees. MTC and PTC were significantly related to gender (male/female: 46/39 vs 46/104, χ2=12.525, P＜0.001), age [(50.11±13.34) years vs (43.63±11.88) years, t=3.838, P＜0.001], and nodule size [(21.66±13.46) mm vs (14.10±9.93) mm, t=4.916, P＜0.001], and the two groups differed significantly in nodule edges (smoothed/unsmoothed: 56/29 vs 19/131, χ2=70.709, P＜0.001), shape (regular/irregular: 34/51 vs 101/49, χ2=16.582, P＜0.001), aspect ratio (＞1/≤1: 10/75 vs 46/104, χ2=10.679, P=0.001), blood supply (low/high: 20/65 vs 65/85, χ2=9.217, P=0.002), and lymph node metastasis (yes/no: 57/28 vs 75/75, χ2=6.413, P=0.011). Multivariate logistic regression analysis showed that smooth tumor edges, irregular shape, and neck lymph node metastasis were independent risk factors (OR=34.786, 95%CI: 12.552-96.405, P＜0.001; OR=0.194, 95%CI: 0.082-0.457, P＜0.001; OR=0.277, 95%CI: 0.109-0.705, P＜0.001).

Conclusion

MTC has the characteristics of being a large mass, smooth edges, irregular shape, rich blood supply, aspect ratio ≤1, and being prone to neck lymph node metastasis. Combined serum calcitonin can improve the diagnostic accuracy.

Key words： Medullary thyroid carcinoma; Ultrasound diagnosis; Papillary thyroid carcinoma

Cite this article

Xin Liu , Qiaodan Zhu , Junping Liu , Dong Xu , Pintong Huang . Ultrasound characteristics of medullary thyroid carcinoma[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2021 , 18(03) : 266 -271 . DOI: 10.3877/cma.j.issn.1672-6448.2021.03.005

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