To achieve efficient, rational, safe and standardized ultrasound contrast infusion, relevant medical, and nursing experts in China summarized the domestic and international literature and clinical experience evidence. After a thorough discussion under the principles of evidence-based medicine, the consensus was proposed, aiming to provide reference opinions for achieving standardization of safe ultrasound contrast infusion in China. The consensus introduces the current situation and safety of ultrasound contrast agent application, relevant regulations and procedures, standardized care before, during, and after imaging, and proposes 16 recommendations. It suggests that the current ultrasound contrast agents approved for market use in China have a high safety profile, and it recommends that healthcare professionals should dispense and administer them according to the latest instructions or expert consensus and that they should be standardized in terms of contrast room management, risk planning, and personnel qualifications.

To evaluate the aortic root parameters of hypertrophic obstructive cardiomyopathy (HOCM) patients in the perioperative period of modified Morrow procedure with eSie Valves software to explore and analyze the change patterns and their causes.

Three-dimensional images of the aortic root were collected by transesophageal three-dimensional echocardiography (3D-TEE) from 23 HOCM patients in the perioperative period of modified Morrow procedure and 23 healthy volunteers (control group). The 3D model of the aortic root was reconstructed with the eSie Valves analysis system. Related parameters were automatically analyzed and compared.

In the HOCM group, the thickness of the obstruction site and the pressure difference of left ventricular outflow tract were significantly lower than those before surgery (P＜0.001). Postoperative mitral regurgitation was significantly reduced in all patients (P＜0.001). A small amount of central aortic regurgitation occurred in 10 patients (43.5%, 10/23), 4 of whom were new. The preoperative height of the aortic root in the HOCM group was significantly lower than that of normal control group [(20.2±3.5) mm vs (23.5±1.8) mm, P＜0.001]. In the HOCM group, compared with the preoperative data, the postoperative coaptation heights of the aortic valve decreased [(11.7±1.3) mm vs (13.0±1.6) mm, P＜0.05], while the aortic root height increased [(25.0±4.8) mm vs (20.2±3.5) mm, P＜0.05].

The eSie Valves 3D automatic quantitative analysis system can be used to reconstruct the aortic valve root model of HOCM, which reveals parts of the structural abnormalities of the aortic root. Modified Morrow procedure could improve the morphology of the aortic root.