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Chinese Journal of Medical Ultrasound (Electronic Edition) >

2021 , Vol. 18 >Issue 06: 590 - 596

DOI: https://doi.org/10.3877/cma.j.issn.1672-6448.2021.06.009

Cardiovascular Ultrasound

Evaluation of left ventricular myocardial systolic function in patients with premature ovarian insufficiency using real-time three-dimensional speckle tracking imaging

  • Yulin Wang ,
  • Lixue Yin ,
  • Mei Li ,
  • Yue Wu ,
  • Zhiyu Guo
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  • 1. Department of Ultrasonic Diagnosis, Chengdu Second People's Hospital, Chengdu 610017, China
    2. Department of Cardiovascular Ultrasound and Cardiac Function, Sichuan People's Hospital & Sichuan Academy of Medical Sciences, Chengdu 610072, China
    3. Department of Obstetrics and Gynecology, Sichuan People's Hospital & Sichuan Academy of Medical Sciences, Chengdu 610072, China
    4. Department of Pharmacy, Sichuan People's Hospital & Sichuan Academy of Medical Sciences, Chengdu 610072, China
    5. GE Healthcare Group Ultrasound Clinical Education Department, Chengdu 600731, China

Received date: 2020-07-03

  Online published: 2021-07-12

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Abstract

Objective

To quantitatively evaluate the changes of subclinical left ventricular myocardial systolic dysfunction in premature ovarian insufficiency (POI) women with normal left ventricular ejection fraction (LVEF) using real-time three-dimensional speckle tracking imaging (RT3D-STI).

Methods

Fifty-four women with normal LVEF diagnosed as having POI were employed as a POI group, and 42 healthy women with matched age, height, and body mass were enrolled as a control group. Both groups underwent conventional transthoracic echocardiography to obtain conventional left ventricular geometric and functional parameters, while RT3D-STI was performed to obtain the three-dimensional left ventricular myocardial systolic function parameters: Global longitudinal strain (GLS), global circumferential strain (GCS), global area strain (GAS), global radial strain (GRS), and three-dimensional left ventricular ejection fraction (3D-LVEF). The differences of the above parameters between the two groups were compared.

Results

The end-diastolic interventricular septal thickness in the POI group was significantly larger than that in the control group (P＜0.05). The values of E, E/A, and lateral e in the POI group were significantly lower than those in the control group (P＜0.01 or P＜0.05). The myocardial performance index in the POI group was significantly higher than that in the control group (P＜0.01). There was no significant difference in two-dimensional left ventricular ejection fraction (2D-LVEF) between the two groups (P＞0.05). The GLS, GCS, GAS, and GRS were significantly decreased in the POI group compared to the control group (P＜0.01), but there was no significant difference in 3D-LVEF between the two groups (P＞0.05).

Conclusion

The left ventricular myocardial systolic function might be impaired subclinically in POI women with normal LVEF. Compared with LVEF, three-dimensional strain parameters of RT3D-STI can be more sensitive to assess the subclinical changes of left ventricular myocardial systolic function for POI women, indicating that RT3D-STI could be used as a non-invasive method to evaluate the early impairment of left ventricular myocardial systolic function in POI women.

Key words： Echocardiography; Speckle tracking imaging; Premature ovarian insufficiency; Ventricular function, left; Myocardial contraction

Cite this article

Yulin Wang , Lixue Yin , Mei Li , Yue Wu , Zhiyu Guo . Evaluation of left ventricular myocardial systolic function in patients with premature ovarian insufficiency using real-time three-dimensional speckle tracking imaging[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2021 , 18(06) : 590 -596 . DOI: 10.3877/cma.j.issn.1672-6448.2021.06.009

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