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中华医学超声杂志（电子版）

中华医学超声杂志（电子版） ›› 2017, Vol. 14 ›› Issue (09) : 680 -684. doi: 10.3877/cma.j.issn.1672-6448.2017.09.010

所属专题： 妇产科超声影像学； 文献； 妇产科超声；

妇产科超声影像学

经阴道三维容积超声检查在多囊卵巢综合征患者诊断中的应用价值
安园园1, 玄英华1, 李晓菲1, 高凤云1, 李贞1, 王娟2, 吴青青1,†()   
  1. 1. 100025　首都医科大学附属北京妇产医院超声科
    2. 100025　首都医科大学附属北京妇产医院内分泌科
  • 收稿日期:2017-03-27 出版日期:2017-09-01
  • 通信作者: 吴青青
  • 基金资助:
    首都医科大学附属北京妇产医院院级课题(2013-09); 登峰人才培养计划(DFL20151302)

The diagnosis value of transvaginal three-dimensional ultrasonography in polycystic ovary syndrome diagnosis

Yuanyuan An1, Yinghua Xuan1, Xiaofei Li1, Fengyun Gao1, Zhen Li1, Juan Wang2, Qingqing Wu1,†()   

  1. 1. Department of Ultrasonography, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
    2. Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
  • Received:2017-03-27 Published:2017-09-01
  • Corresponding author: Qingqing Wu
  • About author:
    Corresponding author: Wu Qingqing, Email:
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安园园, 玄英华, 李晓菲, 高凤云, 李贞, 王娟, 吴青青. 经阴道三维容积超声检查在多囊卵巢综合征患者诊断中的应用价值[J]. 中华医学超声杂志（电子版）, 2017, 14(09): 680-684.

Yuanyuan An, Yinghua Xuan, Xiaofei Li, Fengyun Gao, Zhen Li, Juan Wang, Qingqing Wu. The diagnosis value of transvaginal three-dimensional ultrasonography in polycystic ovary syndrome diagnosis[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2017, 14(09): 680-684.

目的

探讨经阴道三维容积超声检查在多囊卵巢综合征（PCOS）患者诊断中的应用价值。

方法

选取2014年6月至2016年6月首都医科大学附属北京妇产医院收治的PCOS患者75例（PCOS组），同时选取同期50名行孕前检查的孕妇作为健康对照组。应用虚拟器官计算机辅助分析（VOCAL）技术测量所有受检者子宫内膜及卵巢体积，同时应用三维超声自动卵泡容积测量（Sono follicle）技术计数卵泡并测量卵泡体积。采用独立样本t检验比较PCOS组患者与健康对照组受检者子宫内膜体积、卵巢体积、卵泡体积、平均卵泡个数差异；应用Pearson相关分析分析PCOS组患者总卵泡个数与卵巢体积、卵泡体积、血清性激素浓度的相关性。

结果

PCOS组患者子宫内膜体积为（1.6±0.9）cm3，小于健康对照组受检者的（3.1±1.7）cm3，卵巢体积、卵泡体积、平均卵泡个数分别为（13.6±4.6）cm3、（1.9±0.7）cm3、（27.7±7.4）个，均高于健康对照组受检者的（7.4±2.9）cm3、（1.1±0.7）cm3、（8.4±3.4）个，且差异均有统计学意义（t=6.013，P<0.001；t=8.087，P=0.015；t=7.222，P<0.001；t=15.637，P<0.001）。PCOS患者总卵泡个数与卵巢体积、卵泡体积、血清睾酮浓度均呈正相关（r=0.467，P=0.000；r=0.446，P=0.000；r=0.383，P=0.001），与血清促黄体生成素浓度/卵泡雌激素浓度无相关性（r=0.048，P=0.702）。

结论

Sono follicle及VOCAL技术为PCOS诊断提供了一种新的客观的测量方法。

关键词: 多囊卵巢综合征, 经阴道三维容积超声检查, 诊断
Objective

To investigate the diagnosis value of the three-dimensional transvaginal ultrasound volume technology in polycystic ovary syndrome (PCOS).

Methods

Totally 75 patients with PCOS and 50 normal subjects as controls from Beijing Obstetrics and Gynecology Hospital affiliated to Capital Medical University were chosed. The volume of the endometrium and ovaries were measured with virtual organ computer-aided analysis techniques (VOCAL). While the follicular numbers and the volumes were measured by sono follicle technique. The ovarian volumes, the follicular volumes and the endometrial volumes were compared between the two groups. Independent samples t test was used to compare PCOS group patients and healthy subjects with endometrial volumes, ovarian volumes, follicle volumes and the average numbers of follicle. Pearson correlation analysis was used to analyze the correlation between the number of total follicles and the volume of ovary, follicle volume and serum sex hormone concentration in PCOS group.

Results

With the endometrial volume of PCOS patients about (1.6±0.9) cm3 was less than that of the control group [(3.1±1.7) cm3]. The ovarian volume, follicular volume and the average number of follicles were (13.6±4.6) cm3, (1.9±0.7) cm3 and (27.7±7.4). All of them were higher than those in healthy subjects [(7.4±2.9) cm3, (1.1±0.7) cm3, (8.4±3.4)], and the differences were statistically significant (t=6.013, P<0.001; t=8.087, P=0.015; t=7.222, P<0.001; t=15.637, P<0.001). The total number of follicles in PCOS patients were positively correlated with ovarian volume, follicle volume and serum testosterone concentrations (r=0.467, P=0.000; r=0.446, P=0.000; r=0.383, P=0.001). There was no correlation with luteinizing hormone (LH)/thyroid stimulating hormone (TSH) (r=0.048, P=0.702).

Conclusion

The sono follicle and VOCAL technology provide a new and objective measurement method for PCOS diagnosis.

Key words: Polycystic ovary syndrome, Three-dimensional transvaginal ultrasound volume technology, Diagnosis
图3 应用三维超声自动卵泡容积测量技术计数卵泡。每一个卵泡都用不同的颜色进行标记，有多少种颜色就代表卵巢内可探查到多少个卵泡
表1 PCOS组患者与健康对照组受检者一般临床资料及三维容积超声特征比较（±s）
组别 例数 年龄（岁） 体重指数（kg/m2） 子宫内膜体积（cm3） 卵巢体积（cm3） 卵泡体积（ml） 平均卵泡个数（个）
PCOS组 75 26.9±3.0 24.2±4.8 1.6±0.9 13.6±4.6 1.9±0.7 27.7±7.4
健康对照组 50 27.5±4.8 21.0±1.9 3.1±1.7 7.4±2.9 1.1±0.7 8.4±3.4
t值 ? 0.673 4.299 6.013 8.087 7.222 15.637
P值 ? 0.503 <0.001 <0.001 0.015 <0.001 <0.001
图6 多囊卵巢综合征患者总卵泡个数与血清睾酮浓度的相关性
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