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中华医学超声杂志(电子版) ›› 2023, Vol. 20 ›› Issue (10) : 1012 -1015. doi: 10.3877/cma.j.issn.1672-6448.2023.10.002

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儿童难治性甲状腺功能亢进症临床治疗进展
丁娇娇, 宋艳宁, 石文媛()   
  1. 100045 国家儿童医学中心(北京)首都医科大学附属北京儿童医院超声科
    100045 国家儿童医学中心(北京)首都医科大学附属北京儿童医院内分泌遗传代谢科
  • 收稿日期:2023-02-13 出版日期:2023-10-01
  • 通信作者: 石文媛

Progress in clinical treatment of refractory hyperthyroidism in children

Jiaojiao Ding, Yanning Song, Wenyuan Shi()   

  • Received:2023-02-13 Published:2023-10-01
  • Corresponding author: Wenyuan Shi
引用本文:

丁娇娇, 宋艳宁, 石文媛. 儿童难治性甲状腺功能亢进症临床治疗进展[J]. 中华医学超声杂志(电子版), 2023, 20(10): 1012-1015.

Jiaojiao Ding, Yanning Song, Wenyuan Shi. Progress in clinical treatment of refractory hyperthyroidism in children[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(10): 1012-1015.

儿童甲状腺功能亢进症(简称甲亢)特指内源性甲状腺激素合成和分泌过多导致的一系列高代谢症候群。儿童甲亢最常见的病因是Graves病,约占95%以上。儿童和青少年的Graves病发病率因国家和地区而异,为1/10万~14/10万,且处于上升趋势。恢复正常甲状腺功能及避免复发是甲亢的治疗目标,治疗方法主要有:抗甲状腺药物(anti-thyroid drugs,ATD)治疗、放射性碘(radioactive iodine,RAI)治疗及手术治疗,RAI和手术等确定性治疗可能会导致永久性甲状腺功能减退,需要终生服用甲状腺激素替代治疗,且术后仍存在一定复发风险。美国及欧洲甲状腺协会指南推荐将ATD作为儿童甲亢的首选治疗方法,但ATD治疗会出现药物相关不良反应,缓解率低、停药后复发率高以及依从性差等问题,儿童甲亢治疗病情缓解率低和复发率高是目前临床治疗的难点。

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