切换至 "中华医学电子期刊资源库"

中华医学超声杂志(电子版) ›› 2025, Vol. 22 ›› Issue (11) : 1005 -1011. doi: 10.3877/cma.j.issn.1672-6448.2025.11.002

专题笔谈

皮肤无创诊断创新技术的应用进展
施月圆1, 方可1, 王撬1, 秦紫薇2, 赵宇靖2, 郭乐杭1,()   
  1. 1 200072 上海市第十人民医院超声医学科(上海超声诊疗工程技术研究中心)
    2 200050 上海市皮肤病医院影像医学科
  • 收稿日期:2025-08-29 出版日期:2025-11-01
  • 通信作者: 郭乐杭

Advances in application of innovative non-invasive diagnostic technologies in dermatology

Yueyuan Shi, Ke Fang, Qiao Wang   

  • Received:2025-08-29 Published:2025-11-01
引用本文:

施月圆, 方可, 王撬, 秦紫薇, 赵宇靖, 郭乐杭. 皮肤无创诊断创新技术的应用进展[J/OL]. 中华医学超声杂志(电子版), 2025, 22(11): 1005-1011.

Yueyuan Shi, Ke Fang, Qiao Wang. Advances in application of innovative non-invasive diagnostic technologies in dermatology[J/OL]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2025, 22(11): 1005-1011.

表1 皮肤无创诊断核心技术对比
1
Hay RJ, Johns NE, Williams HC, et al. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions [J]. J Invest Dermatol, 2014, 134(6): 1527-1534.
2
徐辉雄, 郭乐航, 王撬. 皮肤超声诊断学[M]. 上海: 上海科学技术出版社, 2020.
3
Wojtowicz I, Żychowska M. Dermoscopy of basal cell carcinoma part 1: dermoscopic findings and diagnostic accuracy—a systematic literature review [J]. Cancers, 2025, 17(3): 493.
4
Wojtowicz I, Żychowska M. Dermoscopy of basal cell carcinoma part 3: differential diagnosis, treatment monitoring and novel technologies [J]. Cancers, 2025, 17(6): 1025.
5
Chen W, Liu Z, Zhou Y, et al. The effect of dermoscopy in assisting on defining surgical margins of basal cell carcinoma [J]. Dermatol Ther, 2022, 35(10): e15711.
6
Wu Y, Sun L. Clinical value of dermoscopy in psoriasis [J]. J Cosmet Dermatol, 2024, 23(2): 370-381.
7
Wang Y, Ding W, Yao M, et al. Diagnostic and grading criteria for androgenetic alopecia using dermoscopy [J]. Skin Res Technol, 2024, 30(4): e13649.
8
Bains P, Kaur S. The role of dermoscopy in severity assessment of alopecia areata: A tertiary care center study [J]. J Clin Aesthet Dermatol, 2020, 13(4): 45-50.
9
Galal SA, Kotb HG, Kamel ROM, et al. Dermoscopic evaluation of nail changes in patients with end-stage renal disease on regular hemodialysis [J]. Skin Appendage Disord, 2025, 11(2): 103-111.
10
Satasia M, Sutaria AH. Nail whispers revealing dermatological and systemic secrets: an analysis of nail disorders associated with diverse dermatological and systemic conditions [J]. Cureus, 2023, 15(9): e45007.
11
Hofny ERM, Tawfik YM, Hasan MS, et al. Dermoscopy of subclinical nail involvement in patients with diabetes mellitus: a case-control study [J]. Clin Exp Dermatol, 2023, 48(5): 490-494.
12
Winkler JK, Kommoss KS, Vollmer AS, et al. Optical super‐high magnification dermoscopy of benign and malignant melanocytic lesions in correlation with histopathology [J]. J Dtsch Dermatol Ges, 2025, 23(5): 610-619.
13
潘庆芝, 李春光. 激光扫描共聚焦显微镜的应用与发展趋势 [J]. 化学教育(中英文), 2025, 46(12): 1-6.
14
Boostani M, Pellacani G, Wortsman X, et al. FDA and EMA-approved noninvasive imaging techniques for basal cell carcinoma subtyping: A systematic review [J]. JAAD Int, 2025, 21: 73-86.
15
Wang ZY, Fei WM, Li CX, et al. Comparison of dermoscopy and reflectance confocal microscopy accuracy for the diagnosis of psoriasis and lichen planus [J]. Skin Res Technol, 2022, 28(3): 480-486.
16
Ishioka P, Costa LL, Maia M. Practical application of laser reflectance confocal microscopy in the follow-up of patients with lentigo maligna undergoing treatment with Imiquimod [J]. An Bras Dermatol, 2022, 97(4): 520-522.
17
Negrutiu M, Danescu S, Popa T, et al. Imaging approach in the diagnostics and evaluation of the psoriasis plaque: a preliminary study and literature review [J]. Diagnostics (Basel), 2024, 14(10): 969.
18
Negrutiu M, Danescu S, Focsan M, et al. Enhancing diagnosis in squamous cell carcinoma: non-invasive imaging and multimodal approach [J]. Diagnostics, 2025, 15(8): 1018.
19
Razi S, Ouellette S, Khan S, et al. Role of VivaScope 2500 ex vivo confocal microscopy in skin pathology: Advantages, limitations, and future prospects [J]. Skin Res Technol, 2023, 29(6): e13388.
20
Chen KJ, Han Y, Wang ZY, et al. Submicron resolution techniques: Multiphoton microscopy in skin disease [J]. Exp Dermatol, 2023, 32(10): 1613-1623.
21
Wang Y, Bai W, Wang X. Progress on three-dimensional visualizing skin architecture with multiple immunofluorescence staining and tissue-clearing approaches [J]. Histol Histopathol, 2025, 40(5): 645-651.
22
Wu Z, Tian Y, Zhao J, et al. Motion-tolerant 3D volumetric multimodality microscopy imaging of human skin with subcellular resolution and extended field-of-view [J]. Commun Biol, 2025, 8(1): 186.
23
Bhatta AK, Keyal U, Liu Y. Application of high frequency ultrasound in dermatology [J]. Discovery Medicine, 2018, 26(145): 237-242.
24
Polańska A, Dańczak-Pazdrowska A, Jałowska M, et al. Current applications of high-frequency ultrasonography in dermatology [J]. Postępy Dermatol Alergol, 2017, 34(6): 535-542.
25
Shung KK. High frequency ultrasonic imaging [J]. Journal of Medical Ultrasound, 2009, 17(1): 25-30.
26
Russo A, Reginelli A, Lacasella GV, et al. Clinical application of ultra-high-frequency ultrasound [J]. J Pers Med, 2022, 12(10): 1733.
27
Alfageme F, Wortsman X, Catalano O, et al. European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) position statement on dermatologic ultrasound [J]. Ultraschall Med, 2021, 42(1): 39-47.
28
Izzetti R, Vitali S, Aringhieri G, et al. Ultra-high frequency ultrasound, a promising diagnostic technique: review of the literature and single-center experience [J]. Can Assoc Radiol J, 2021, 72(3): 418-431.
29
王子, 王曦曦, 朱强, 等. 超声影像在皮肤病变诊断中的应用研究 [J/CD]. 中华医学超声杂志(电子版), 2019, 16(6): 407-418.
30
Wortsman X, Carreño L, Ferreira‐Wortsman C, et al. Ultrasound characteristics of the hair follicles and tracts, sebaceous glands, montgomery glands, apocrine glands, and arrector pili muscles [J]. J Ultrasound Med, 2019, 38(8): 1995-2004.
31
Granieri G, Oranges T, Morganti R, et al. Ultra‐high frequency ultrasound detection of the dermo‐epidermal junction: its potential role in dermatology [J]. Exp Dermatol, 2022, 31(12): 1863-1871.
32
Li L, Xu J, Wang S, et al. Ultra-high-frequency ultrasound in the evaluation of paediatric pilomatricoma based on the histopathologic classification [J]. Front Med(Lausanne), 2021, 8: 673861.
33
Sechi A, Starace M, Piraccini BM, et al. Ultrasound features of onychopapilloma at high‐frequency and ultra‐high frequency [J]. J Ultrasound Med, 2024, 43(1): 71-76.
34
Guérin‐Moreau M, Lefthériotis G, Le Corre Y, et al. High‐frequency (20–50 MHz) ultrasonography of pseudoxanthoma elasticum skin lesions [J]. Br J Dermatol, 2013, 169(6): 1233-1239.
35
Mlosek RK, Malinowska S, Woźniak W. Lipoma removal using a high‐frequency ultrasound‐guided injection of a Class III CE‐marked device—Empirical findings [J]. J Cosmetic Dermatol, 2019, 18(2): 469-473.
36
李娅荣, 姜凡, 彭梅. 多模态超高频超声评估皮肤肿瘤良恶性的价值 [J]. 中国医学影像学杂志, 2025, 33(4): 409-413.
37
Chauvel-Picard J, Tognetti L, Cinotti E, et al. Role of ultra-high-frequency ultrasound in the diagnosis and management of basal cell carcinoma: pilot study based on 117 cases [J]. Clin Exp Dermatol, 2023, 48(5): 468-475.
38
Janowska A, Oranges T, Iannone M, et al. Ultra-high-frequency ultrasound monitoring of melanomas arising in congenital melanocytic nevi: a case series [J]. Melanoma Res, 2021, 31(6): 561-565.
39
Michelucci A, Dini V, Salvia G, et al. Assessment and monitoring of nail psoriasis with ultra-high frequency ultrasound: preliminary results [J]. Diagnostics, 2023, 13(16): 2716.
40
Wortsman X, Araya I, Maass M, et al. Ultrasound patterns of vitiligo at high frequency and ultra‐high frequency [J]. J Ultrasound Med, 2024, 43(9): 1605-1610.
41
Noe MH, Rodriguez O, Taylor L, et al. High frequency ultrasound: a novel instrument to quantify granuloma burden in cutaneous sarcoidosis [J]. Sar Vasc Diffuse Lung Dis, 2017, 34(2): 136-141.
42
Granieri G, Michelucci A, Cei B, et al. Ultra-high frequency ultrasound (UHFUS) features of pyoderma gangrenosum, venous leg ulcers, and acute ulcerative lesions [J]. Int J Low Extrem Wounds, 2025: 15347346251324503.
43
Di Battista M, Vitali S, Barsotti S, et al. Ultra-high frequency ultrasound for digital arteries: improving the characterization of vasculopathy in systemic sclerosis [J]. Semin Arthritis Rheum, 2022, 57: 152105.
44
Kinoshita-Ise M, Ohyama M, Ramjist JM, et al. Ultra high-frequency ultrasound with seventy-MHz transducer in hair disorders: Development of a novel noninvasive diagnostic methodology [J]. J Dermatol Sci, 2021, 102(3): 167-176.
45
Michelucci A, Granieri G, Scatena C, et al. Correlation between ultra‐high frequency ultrasound (UHFUS) and histological features of typical lesions in hidradenitis suppurativa [J]. J Ultrasound in Med, 2025, 44(11): 2149-2156.
46
Michelucci A, Fidanzi C, Margiotta FM, et al. Presurgical mapping with ultra-high frequency ultrasound of hidradenitis suppurativa lesions treated with wide local excision and secondary intention healing [J]. Dermatol Surg, 2025, 51(1): 36-39.
47
Guo X, Wang Y, Yao Y, et al. Sub-macroscopic skin presentation of acromegaly and effect of pituitary tumor surgery: A study using dermatoscopy and ultra-high-frequency ultrasound [J]. Front Endocrinol(Lausanne), 2023, 13: 1093942.
48
Liu ZF, Chew CY, Honavar S, et al. Seeing beyond skin deep: high‐resolution ultrasound in dermatology—a comprehensive review and future prospects [J]. J Eur Acad Dermatol Venereol, 2024, 38(7): 1305-1313.
49
Guida S, Arginelli F, Farnetani F, et al. Clinical applications of in vivo and ex vivo confocal microscopy [J]. Applied Sciences, 2021, 11(5): 1979.
50
Aringhieri G, Izzetti R, Vitali S, et al. Ultra-high frequency ultrasound (UHFUS) applications in Sjogren syndrome: Narrative review and current concepts [J]. Gland Surg, 2020, 9(6): 2248-2259.
51
von Knorring T, Blanche P, Holstad Pedersen H, et al. Diagnostic accuracy of expeditious bedside evaluation of cutaneous malignant melanoma using photoacoustic imaging [J]. J Eur Acad Dermatol Venereol, 2025, 39(1): e23-e25.
52
Lara JB, Prakash R, Tsoukas MM, et al. Second generation of linear array photoacoustic imaging for melanoma thickness measurement[C]// Photonics in Dermatology and Plastic Surgery 2025. SPIE, 2025, 13292: 159-166.
53
Li X, Teo VX, Kwa CY, et al. A proof-of-concept study for precise mapping of pigmented basal cell carcinoma in Asian skin using multispectral optoacoustic tomography imaging with level set segmentation [J]. Eur J Nucl Med Mol Imaging, 2025, 52(7): 2617-2627.
54
Li X, Yew YW, Ram KV, et al. Structural and functional imaging of psoriasis for severity assessment and quantitative monitoring of treatment response using high-resolution optoacoustic imaging [J]. Photoacoustics, 2024, 38: 100611.
55
Daoudi K, Kersten BE, van den Ende CHM, et al. Photoacoustic and high-frequency ultrasound imaging of systemic sclerosis patients [J]. Arthritis Res Ther, 2021, 23(1): 22.
56
Huynh NT, Zhang E, Francies O, et al. A fast all-optical 3D photoacoustic scanner for clinical vascular imaging [J]. Nat Biomed Eng, 2025, 9(5): 638-655.
57
Teng F, Huang D, Cui H. Preliminary study on assessing skin changes in Henoch-Schönlein purpura patients using high-frequency ultrasound and shear wave elastograph [J]. Arch Dermatol Res, 2025, 317(1): 541.
58
Bhatti A, Kanno N, Ikeda H, et al. Development of an imaging framework for visualization of cutaneous micro-vasculature by using high frequency ultrafast ultrasound imaging [J]. Annu Int Conf IEEE Eng Med Biol Soc, 2022: 190-193.
59
Xia SJ, Zheng YH, Hua Q, et al. Super-resolution ultrasound-based habitat imaging: a consensus statement [J]. Advanced Ultrasound in Diagnosis and Therapy (AUDT), 2025, 9(2): 97-102.
60
Joshi SV, Sadeghpour S, Kuznetsova N, et al. Flexible micromachined ultrasound transducers (MUTs) for biomedical applications [J]. Microsyst Nanoeng, 2025, 11(1): 9.
61
Zhu AQ, Chen XW, Xu WC, et al. Value of diagnosis and management for skin lesions by integration of high-frequency ultrasound in daily practices: a prospective study [J]. Dermatology, 2025, 241(4): 336-343.
62
Shan D, Wu N, Wang Q, et al. Value of pseudopod sign on high‐frequency ultrasound in predicting the pathological invasion of extramammary Paget's disease lesions [J]. J Eur Acad Dermatol Venereol, 2022, 36(8): 1235-1245.
63
Zhu AQ, Wang Q, Shi YL, et al. A deep learning fusion network trained with clinical and high-frequency ultrasound images in the multi-classification of skin diseases in comparison with dermatologists: a prospective and multicenter study [J]. EClinicalMedicine, 2024, 67: 102391.
64
Czajkowska J, Badura P, Korzekwa S, et al. Automated segmentation of epidermis in high-frequency ultrasound of pathological skin using a cascade of DeepLab v3+ networks and fuzzy connectedness [J]. Comput Med Imaging Graph, 2022, 95: 102023.
65
Vergilio MM, Kiihl SF, Florindo JB, et al. Enhancing skin aging parameter assessment in clinical trials: AI-Driven analysis of ultrasound images [J]. Biomedical Signal Processing and Control, 2025, 100: 106962.
66
Dai X, Lu H, Wang X, et al. Development of ultrasound-based clinical, radiomics and deep learning fusion models for the diagnosis of benign and malignant soft tissue tumors [J]. Front Oncol, 2024, 14: 1443029.
67
Lee S, Rahul Lukan J, et al. A deep learning model for burn depth classification using ultrasound imaging [J]. J Mech Behav Biomed Mater, 2022, 125: 104930.
No related articles found!
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?