探讨主动脉僵硬度超声定量检测在强直性脊柱炎（AS）患者心血管疾病发生风险早期预测中的临床应用价值。

纳入2024年6月1日至12月31日期间在汉中市中心医院接受诊治的AS患者（AS组），同期招募年龄、血压相匹配的健康志愿者（健康对照组）。根据传统危险因素计算Framingham风险评分（FRS）和未来十年心血管疾病发生风险，并采用Mann-Whitney U检验比较组间差异。采用超声动脉僵硬度自动定量测量新技术测量颈-股脉搏波传播速度（cfPWV），采用独立样本t检验比较组间差异，采用Spearman相关分析cfPWV与FRS和未来十年心血管疾病发生风险的相关性，并采用多因素线性回归模型分析各混杂因素与cfPWV间的独立相关性。

研究共纳入AS组患者40例，健康对照组48人。健康对照组的FRS为5.00（2.00，7.00）分，对应的未来十年心血管疾病发生风险为3.60%（2.01%，5.60%），AS组FRS为7.50（2.25，10.75）分，未来十年心血管疾病发生风险为4.60%（2.01%，9.85%），2组比较差异均无统计学意义（P均＞0.05）。AS组患者的cfPWV较对照组显著升高[（7.56±1.45）m/s vs（6.80±0.72）m/s]，差异具有统计学意义（t=3.200，P=0.002），且AS组患者的cfPWV与FRS、未来十年心血管疾病发生风险存在显著正相关关系（r_s=0.614、0.574，P均＜0.001）。多因素线性回归分析显示，年龄、平均动脉压、心率和AS是cfPWV的独立影响因素（P均＜0.05），在校正年龄、平均动脉压和心率后，是否患AS仍是cfPWV的独立影响因素（P=0.037）。

基于超声技术的主动脉僵硬度定量检测有望为临床AS患者的心血管健康风险评估提供一种新方法，AS患者的主动脉僵硬度较健康人群显著增高，提示其心血管疾病风险可能升高。

To investigate the clinical utility of quantitative measurement of aortic stiffness based on ultrasonography for early detection of cardiovascular (CV) disease risk in patients with ankylosing spondylitis (AS).

Patients with AS (AS group) who were diagnosed and treated at Hanzhong Central Hospital from June 1 to December 31, 2024 were included, and healthy volunteers (healthy control group) matched in age and blood pressure were recruited at the same time. The Framingham risk score (FRS) and the corresponding risk of CV disease in the next 10 years based on traditional CV risk factors were calculated, with differences compared using the Mann-Whitney U test. Carotid-femoral pulse wave velocity (cfPWV) was measured by ultrasonography via a novel automatic measurement of arterial stiffness and independent sample t-tests were used to compare differences between groups. Spearman correlation analysis was performed to explore the correlations between cfPWV and FRS as well as the risk of cardiovascular diseases in the next 10 years. The independent correlations between confounding factors and cfPWV were analyzed using a multivariate linear regression model.

A total of 40 AS patients and 48 healthy controls were included. The FRS of the healthy control group was 5.00 (2.00, 7.00), and the corresponding risk of CV disease in the next 10 years was 3.60% (2.01%, 5.60%); the corresponding values in the AS group were 7.50 (2.25, 10.75) and 4.60% (2.01%, 9.85%). There was no statistically significant difference in the FRS or risk of CV disease between the two groups (P＞0.05). The cfPWV of the patients was significantly higher than that of the control group (7.56±1.45 m/s vs 6.80±0.72 m/s, t=3.200, P=0.002). Among AS patients, cfPWV was significantly correlated with the FRS and the risk of CV disease in the next 10 years (r_s=0.614 and 0.574, respectively, P＜0.001). Multivariate linear regression analysis showed that age, mean arterial pressure, heart rate, and AS were independent influencing factors of cfPWV (all P＜0.05). After adjusting for age, mean arterial pressure, and heart rate, AS were also independent influencing factors of cfPWV (P=0.037).

Quantitative detection of aortic stiffness based on ultrasound technology is expected to provide a new method for CV risk assessment in AS patients. The aortic stiffness of AS patients is significantly higher than that of healthy subjects, suggesting that the risk of CV disease in these patients may increase.