Three-dimensional longitudinal strain in evaluating the changes of left ventricular myocardial contractional function in early chronic kidney disease patients

doi:10.3877/cma.j.issn.1672-6448.2016.04.008

Abstract

Abstract:

Objective

To assess the early changes of left ventricular myocardial contractional function in early chronic kidney disease (CKD) patients with three-dimensional global longitudinal strain (GLS).

Methods

Twenty-six cases of CKD 2, 20 cases of CKD 3 and 30 cases of healthy subjects as control group were selected in this study. Parameters of two-dimensional echocardiography including left ventricular at end-diastole diameter (LVEDd), interventricular septal thickness at end-diastole (IVSTd), left ventricular posterior wall thickness at end-diastole (LVPWTd), end-diastolic volume (EDV), end-systolic volume (ESV) and parameters of 3D-STE including three-dimensional left ventricular ejection fraction (3D-LVEF), three-dimensional LV mass index (3D-LVMi) and global longitudinal strain (GLS) were calculated and compared.

Results

Compared with the control group, IVSTd of patients in CKD 2 group increased [(9.62±2.33) mm vs (8.17±0.79) mm] while LVEDd and GLS decreased [(45.08±3.26) mm vs (47.13±3.30) mm and (-15.52±3.52)% vs (-17.20±2.15)%]; in CKD3 group, IVSTd, LVESV and 3D-LVMi increased [(11.24±1.01) mm vs (8.17±0.79) mm, (37.80±4.48) ml vs (33.53±7.00) ml and (107.90±16.31) g/m² vs (90.70±7.75) g/m²] while LVEDd, 3D-LVEF and GLS decreased [(43.47±1.58) mm vs (47.13±3.30) mm, (57.50±2.96)% vs (60.30±3.72)% and (-9.76±3.48)% vs (-17.20±2.15)%]. Compared with the CKD 2 group, in CKD3 group, IVSTd and 3D-LVMi increased [(11.24±1.01) mm vs (9.62±2.33) mm and (107.90±16.31) g/m² vs (94.77±10.14) g/m²] while LVEDd and GLS decreased [(43.47±1.58) mm vs (45.08±3.26) mm and (-9.76±3.48)% vs (-15.52±3.52)%] (P<0.05).

Conclusion

On the early stages of CKD, the left ventricular myocardial contractive function has reduced, which can be detected by 3D-STE with GLS.

Key words: Echocardiography, three-dimensional, Chronic kidney disease, Ventricular function, left

Kaiwei Liu, Weidong Ren, Lu Sun, Guang Song, Hui Liu, Jinling Hu. Three-dimensional longitudinal strain in evaluating the changes of left ventricular myocardial contractional function in early chronic kidney disease patients[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2016, 13(04): 271-275.

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References 15

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组别	例数	男/女	年龄（岁）	身高（cm）	体重（kg）	收缩压（mmHg）	舒张压（mmHg）	血清肌酐（μmol/L）
对照组	30	16/14	49.47±5.63	165.87±7.48	62.23±5.84	120.07±10.60	81.80±5.65	-
CKD 2期	26	14/12	46.50±9.91	168.35±8.58	63.46±5.62	128.08±11.50^a	85.58±8.87^a	147.82±19.12
CKD 3期	20	11/9	48.95±9.72	166.05±8.74	61.90±8.17	153.75±18.49^a	89.25±6.93	311.62±62.88

组别	例数	男/女	年龄（岁）	身高（cm）	体重（kg）	收缩压（mmHg）	舒张压（mmHg）	血清肌酐（μmol/L）
对照组	30	16/14	49.47±5.63	165.87±7.48	62.23±5.84	120.07±10.60	81.80±5.65	-
CKD 2期	26	14/12	46.50±9.91	168.35±8.58	63.46±5.62	128.08±11.50^a	85.58±8.87^a	147.82±19.12
CKD 3期	20	11/9	48.95±9.72	166.05±8.74	61.90±8.17	153.75±18.49^a	89.25±6.93	311.62±62.88

组别	例数	IVSTd（mm）	LVPWTd（mm）	LVEDd（mm）	LVEDV（ml）	LVESV（ml）	3D-LVEF（%）	3D-LVMi（g/m²）	GLS（%）
对照组	30	8.17±0.79	8.13±0.63	47.13±3.30	88.40±10.03	33.53±7.00	60.30±3.72	90.70±7.75	-17.20±2.15
CKD 2期	26	9.62±2.33^a	8.14±0.84	45.08±3.26^a	90.12±16.47	37.04±10.15	59.35±5.39	94.77±10.14	-15.52±3.52^a
CKD 3期	20	11.24±1.01^b	8.46±0.79	43.47±1.58^b	89.20±10.90	37.80±4.48^b	57.50±2.96^b	107.90±16.31^b	-9.76±3.48^b

组别	例数	IVSTd（mm）	LVPWTd（mm）	LVEDd（mm）	LVEDV（ml）	LVESV（ml）	3D-LVEF（%）	3D-LVMi（g/m²）	GLS（%）
对照组	30	8.17±0.79	8.13±0.63	47.13±3.30	88.40±10.03	33.53±7.00	60.30±3.72	90.70±7.75	-17.20±2.15
CKD 2期	26	9.62±2.33^a	8.14±0.84	45.08±3.26^a	90.12±16.47	37.04±10.15	59.35±5.39	94.77±10.14	-15.52±3.52^a
CKD 3期	20	11.24±1.01^b	8.46±0.79	43.47±1.58^b	89.20±10.90	37.80±4.48^b	57.50±2.96^b	107.90±16.31^b	-9.76±3.48^b

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