Correlation of the ultrasonic appearance and pathological/laboratory findings in autoimmune hepatitis

doi:10.3877/cma.j.issn.1672-6448.2018.04.006

Abstract

Abstract:

Objective

The study was designed to comparatively analyze ultrasonic appearance, laboratory and pathological findings in autoimmune hepatitis (AIH), and their correlation. The clinical value of ultrasound in diagnosing autoimmune hepatitis was studied.

Methods

By retrospectively reviewing the ultrasonic images, pathological and laboratory results of 68 patients with autoimmune hepatitis admitted to the PLA 302 Hospital from 2014 to 2015, we tried to reveal the correlation between ultrasonic features and pathological and laboratory findings.

Results

The ultrasonic diagnosis of liver fibrosis was not statistically correlated with the features of pathological ″interface hepatitis″ and serological liver function test. But it was positively correlated with the features of pathological ″spotty necrosis″ (r=0.5099, P<0.001). The ultrasonic features of ″cord-like structure″ and ″nodular change″ had statistically improved the classification of the degree of AIH fibrosis on ultrasonic diagnosis (t=3.9547, P<0.01). The ultrasonic feature of the change of ″liver size″ and ″morphology″ also have statistically improved the diagnosis of AIH fibrosis with ultrasonography (t=2.070, 2.137, 4.584, 3.773, all P<0.05).

Conclusion

Ultrasonic images could provide objective evidence in diagnosis of AIH and evaluation of fibrosis degree.

Key words: Autoimmune hepatitis, Ultrasonic, Pathology, Biological markers

Xi Chen, Zhiyan Li, Lin Che, Meng Li, Yan Wang, Yanxian Zhou, Yang Liu. Correlation of the ultrasonic appearance and pathological/laboratory findings in autoimmune hepatitis[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2018, 15(04): 263-267.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2018.04.006

https://chaosheng.cma-cmc.com.cn/EN/Y2018/V15/I04/263

Figures/Tables 2

References 13

[1]	Gatselis NK,Zachou K,Koukoulis GK, et al. Autoimmune hepatitis, one disease with many faces: etiopathogenetica, clinico-laboratory and histological characteristics[J]. World J Gastroenterol, 2015, 21(1): 60-83.
[2]	Longhi MS,Mieli-Vergani G,Vergani D. Autoimmune hepatitis[J]. Curr Pediatr Rev, 2015, 10(4): 268-274.
[3]	Czaja AJ. Autoimmune hepatitis. Current therapeutic concepts[J]. Clin Immunotherapy, 1994, 1: 413-429.
[4]	Strassburg CP,Manns MP. Autoantibodies and autoantigens in autoimmune hepatitis[J]. Semin Liver Dis, 2002, 22(4): 339-352.
[5]	Miyake Y,Iwassaki Y,Terada R, et al. Clinical features of Japanese type 1 autoimmune hepatitis patients with zone III necrosis[J]. Hepatol Res, 2007, 37(10): 801-805.
[6]	Alvarez F,Berg PA,Bianch FB, et al. International Autoinnune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis[J]. J Hepatology, 1999, 31(5): 929-938
[7]	Licata A,Maida M,Cabibi D, et al. Clinical features and outcomes of patients with drug-induced autoimmune hepatitis: a retrospective cohort study[J]. Dig Liver Dis, 2014, 46(12): 1116-1120.
[8]	Sasali M,Yamauchi K,Tokushige K, et al. Clinical significance of autoantibody to hepatocyte membrane antigen in type1 autoimmune hepatitis[J]. Am J Gastroenterol, 2001, 96(3): 846-851.
[9]	Czaja AJ,Cassani F,Caraleta M, et al. Antinuclear antibodies and patterns of nuclear immunofluoresccence in type 1 autoimmune hepatitis[J]. Dig Dis Sci, 1997, 42(8): 1688-1696.
[10]	孟繁坤, 杨琛, 刘英, 等. 慢性病毒性肝炎胆囊超声观察指标与肝脏组织病理G、S关系研究[J]. 中国超声医学杂志, 2010, 26(8): 738-741.
[11]	Czaja AJ,Carpenter HA. Distinctive clinical phenotype and treatment outcome of type 1 autoimmune hepatitis in the elderly[J]. Hepatology, 2006, 43(3): 532-538.
[12]	王继涛, 朱振宇, 王冰, 等. 自身免疫性肝炎相关肝癌的临床特点和预后分析[J]. 中华肝胆外科杂志, 2014, 30(3): 181-185.
[13]	Odze RD,Goldblum JR. Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas [M]. 2 nd. Philadelphia, PA: Saunders Elesvier, 2009: 1035-1043.

参数	参数估计	标准误	t值	P值
Intercept	1.080812	0.512684	2.108	0.03992
性别	0.104347	0.236533	0.441	0.660968
年龄	-0.005302	0.005371	-0.987	0.3282
气球样变	0.091945	0.173548	2.849	0.598554
点状坏死	0.299119	0.104979	2.849	0.006304
假小叶	0.314652	0.198034	1.589	0.118268
界面炎	-0.218061	0.141963	-1.536	0.130709
肝大小	0.417317	0.201623	2.070	0.043555
形态	0.341375	0.159709	2.137	0.037374
增粗	-0.105559	0.232254	-0.454	0.6514
条索	1.001526	0.218494	4.584	0.0000298
结节	0.863230	0.228810	3.773	0.000422
斑片	-0.262337	0.227104	-1.155	0.253415
胆囊	0.053104	0.052651	1.009	0.317929
脾厚	0.016764	0.021284	0.788	0.434549
脾长	-0.00668	0.006641	-1.006	0.319281

参数	参数估计	标准误	t值	P值
Intercept	1.080812	0.512684	2.108	0.03992
性别	0.104347	0.236533	0.441	0.660968
年龄	-0.005302	0.005371	-0.987	0.3282
气球样变	0.091945	0.173548	2.849	0.598554
点状坏死	0.299119	0.104979	2.849	0.006304
假小叶	0.314652	0.198034	1.589	0.118268
界面炎	-0.218061	0.141963	-1.536	0.130709
肝大小	0.417317	0.201623	2.070	0.043555
形态	0.341375	0.159709	2.137	0.037374
增粗	-0.105559	0.232254	-0.454	0.6514
条索	1.001526	0.218494	4.584	0.0000298
结节	0.863230	0.228810	3.773	0.000422
斑片	-0.262337	0.227104	-1.155	0.253415
胆囊	0.053104	0.052651	1.009	0.317929
脾厚	0.016764	0.021284	0.788	0.434549
脾长	-0.00668	0.006641	-1.006	0.319281

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