Pathologic analysis of supersonic shear elastography in breast invasive ductal carcinoma

doi:10.3877/cma.j.issn.1672-6448.2018.05.010

Abstract

Abstract:

Objective

To investigate the correlation between the values of shear wave elastic modulus and collagen fibers morphology and arrangement of breast invasive ductal carcinomas.

Methods

Thirty-five breast invasive ductal carcinomas were performed conventional ultrasound and shear wave elastography (SWE) before operation. All specimens underwent special pathological staining. The morphological characteristics and arrangement of collagen fibers were analyzed and classified. And the classification and the maximum modulus of elasticity of the tumor were compared.

Results

In 35 cases of breast invasive ductal carcinoma, typeⅠcollagen fiber accounted for 83% of the total collagen area. All collagen fibers exhibited morphology of long and straight, and the average elasticity of 29 cases (152.9±93.4 kPa) with collagen fibers morphology of long, straight and thin was higher than the average elasticity of 6 cases (74.8±6.4 kPa) with collagen fibers morphology of of long, straight and thick. According to the classification of collagen arrangement, 35 cases were classified to honeycomb, platelike, layered and interlaced arrangement. The average elasticity of collagen fibers with honeycomb (6 cases), platelike (10 cases), layered (11 cases), and interlaced arrangement (8 cases) was 252.2 kPa, 152.4 kPa, 120.6 kPa and 65.0 kPa respectively. The average elasticity modulus value of collagen fibers with honeycomb was the highest of other three kinds of them.

Conclusion

Different morphology and arrangement of collagen fibers are important causes with different stiffness in invasive ductal brseast carcinoma.

Key words: Breast, Invasive ductal carcinoma, Shear wave elastography, Collagen, Pathology

Junlai Li, Xianquan Shi, Xiaolin Cao, jie Li, Danfei Song, Tengfei Yu, Xin Zhao, Huaiyin Shi. Pathologic analysis of supersonic shear elastography in breast invasive ductal carcinoma[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2018, 15(05): 374-378.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2018.05.010

https://chaosheng.cma-cmc.com.cn/EN/Y2018/V15/I05/374

Figures/Tables 3

References 16

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分类	例数	弹性最大值（±s，kPa）
长直细胶原纤维	29	152.9±93.4
长直粗胶原纤维	6	74.8±6.4

分类	例数	弹性最大值（±s，kPa）
长直细胶原纤维	29	152.9±93.4
长直粗胶原纤维	6	74.8±6.4

纤维排列方式	例数	弹性最大值（±s，kPa）
分层	11	120.6±80.4
片状	10	152.4±73.7
交错状	8	65.0±39.3
蜂窝状	6	252.2±69.5

纤维排列方式	例数	弹性最大值（±s，kPa）
分层	11	120.6±80.4
片状	10	152.4±73.7
交错状	8	65.0±39.3
蜂窝状	6	252.2±69.5

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