Quantification of passive muscle stiffness in Parkinson's disease by dynamic shear wave elastography

doi:10.3877/cma.j.issn.1672-6448.2021.07.015

Abstract

Abstract:

Objective

To investigate the clinical value of dynamic shear wave elastography in the evaluation of muscular rigidity in Parkinson's disease.

Methods

From January to September 2019, 28 patients confirmed with Parkinson's disease and 10 healthy controls at Beijing Tiantan Hospital, Capital Medical University were recruited. Dynamic shear wave elastography was used to record the elastic modulus of the medial gastrocnemius during the ankle joint passive dorsiflexion, the curves of elastic modulus-ankle joint angles were described, and the differences of curve parameters, muscle elastic modulus in relaxation (E₀), and slack angle (beyond which the muscle begins to develop passive tension) between the two groups were compared by t-test.

Results

The mean E₀ in the Parkinson's disease group was significantly lower than that in the healthy control group [(10.30±2.75) kPa vs (11.64±1.26) kPa; t=-2.704, P＝0.009). The slack angle in the Parkinson's disease group was significantly smaller than that of the healthy control group (-27.49±5.23)° vs (-21.77±4.58)°; t=-4.168, P＜0.001). There was no significant difference in gastrocnemius muscle thickness or muscle length between the two groups (P＞0.05).

Conclusion

Dynamic shear wave elastography can be used to detect the biomechanical characteristics of Parkinson's disease, such as the state of muscle rigidity.

Key words: Parkinson's disease, Ultrasound, Shear wave, Elastography, Slack angle

Yuanzi Li, Lu Yin, Wen He, Yang Xiao, Yongjin Zhou, Yumeng Wang, Jing Yang, Wenyan Huang, Huiqin Zhang, Huizi Ma, Lijuan Du. Quantification of passive muscle stiffness in Parkinson's disease by dynamic shear wave elastography[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2021, 18(07): 696-700.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2021.07.015

https://chaosheng.cma-cmc.com.cn/EN/Y2021/V18/I07/696

Figures/Tables 4

References 16

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组别	组数	肌腹厚度（cm）	肌肉长度（cm）	E₀（kpa）	松弛角（°）
帕金森病组	56	1.51±0.28	21.72±1.54	10.30±2.75	-27.49±5.23
健康对照组	20	1.64±0.26	21.22±1.67	11.64±1.26	-21.77±4.58
t值		-1.744	1.116	-2.704	-4.168
P值		0.085	0.609	0.009	＜0.001

组别	组数	肌腹厚度（cm）	肌肉长度（cm）	E₀（kpa）	松弛角（°）
帕金森病组	56	1.51±0.28	21.72±1.54	10.30±2.75	-27.49±5.23
健康对照组	20	1.64±0.26	21.22±1.67	11.64±1.26	-21.77±4.58
t值		-1.744	1.116	-2.704	-4.168
P值		0.085	0.609	0.009	＜0.001

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