To study the parameters of the choroid plexus of the lateral ventricle in normal fetuses during 11 to 13⁺⁶ weeks of gestation and to analyze their clinical value.

From January 2017 to January 2021, 277 normal fetuses (during 11 to 13⁺⁶ weeks of gestation) who underwent fetal structure screening at the Second Affiliated Hospital of Anhui Medical University were selected to measure the length and area of bilateral ventricular choroid plexus and the length of the cerebral falx (CF-L). The length and area of the choroid plexus of bilateral ventricles were analyzed by paired t test. Pearson correlation analysis was performed to determine the correlation between the mean length of the choroid plexus of lateral ventricle (CP-L), the total area of the choroid plexus of lateral ventricle (CP-A), CP-L/CF-L ratio, and crown-rump length (CRL). Using CRL as the independent variable and CP-L, CP-A, and CP-L/CF-L ratio as dependent variables, a simple linear regression model was used to explore the relationship between the variables, and linear regression equations between CRL and the values of related parameters were established. Meanwhile, the parameters of 11 fetuses with abnormal choroid plexus of the lateral ventricle were analyzed, who underwent fetal structure screening at the Second Affiliated Hospital of Anhui Medical University during 11 to 13⁺⁶ weeks of gestation from January 2017 to March 2022.

There were no statistically significant differences in the length and area of the choroid plexus between the left and right lateral ventricles in normal fetuses during 11 to 13⁺⁶ weeks of gestation (P＞0.05). The linear regression equation of CP-L and CRL was: CP-L=0.134×CRL＋0.577 (r=0.681, P＜0.001), showing a positive linear correlation. The linear regression equation of CP-A and CRL was: CP-A=0.251×CRL-0.267 (r=0.736, P＜0.001), showing a positive linear correlation. The linear regression equation of CP-L/CF-L ratio and CRL was: CP-L/CF-L ratio=-0.047×CRL＋1.011 (r=-0.514, P＜0.001), showing a linear negative correlation. There were 11 cases of abnormal lateral ventricular choroid plexus in early pregnancy, including 3 cases of bilateral choroid plexus fusion, 1 case of absence of lateral ventricular choroid plexus, 1 case of asymmetric lateral ventricular choroid plexus, and 6 cases of small lateral ventricular choroid plexus.

CP-L, CP-A, and CP-L/ CF-L are linearly correlated with CRL during 11 to 13⁺⁶ weeks of gestation, which provides a reference range for the examination of the choroid plexus of the lateral ventricle and has appreciated clinical significance.