Value of high-frame-rate contrast-enhanced ultrasound in evaluation of pseudocapsule sign in small clear cell renal carcinoma

doi:10.3877/cma.j.issn.1672-6448.2023.11.002

Abstract

Abstract:

Objective

To evaluate the value of high-frame-rate contrast-enhanced ultrasound (H-CEUS) in evaluating the pseudocapsule sign in small clear cell renal carcinoma (S-CCRCC).

Methods

A retrospective analysis was performed on 80 cases of S-CCRCC confirmed by surgery and pathology at the First Medical Center of PLA General Hospital from September 2022 to April 2023, and they were divided into two groups according to tumor size: maximum diameter ≤ 2.0 cm group (n=30) and maximum diameter 2.1-4.0 cm group (n=50). Conventional CEUS and H-CEUS examinations were performed on the study subjects and the image data were recorded. Then, the conventional CEUS and H-CEUS images were analyzed by two observers respectively, and the evaluation results were given according to the display degree of the pseudocapsule sign during conventional CEUS and H-CEUS: completely visible, partially visible, and completely invisible. The features and results of CEUS and H-CEUS images were statistically analyzed, and Kappa test was used to assess the consistency in the evaluation results of the two observers.

Results

In the evaluation results of the two groups of S-CCRCC, the display of the pseudocapsule sign by H-CEUS was better than that by CEUS, and the proportion of cases with completely visible pseudocapsule sign of S-CCRCC was improved. In the CEUS mode, the Kappa coefficient for the pairwise comparison between the two observers was 0.605 in the ≤2.0 cm group [95% confidence interval (CI): 0.396-0.814], and it was 0.745 (95%CI: 0.568-0.922) in the 2.1-4.0 cm group. In the H-CEUS model, the Kappa coefficient in the ≤2.0 cm group was 0.813 (95%CI: 0.646-0.980), and it was 0.862 (95%CI: 0.709-1.000) in the 2.1-4.0 cm group.

Conclusion

H-CEUS can make the pseudocapsule sign of S-CCRCC more clearly displayed, and the consistency of evaluation results between different observers is significantly improved.

Key words: Contrast-enhanced ultrasound, High frame rate, Small renal carcinoma, Pseudocapsule sign

Qiuyang Li, Ping Zhao, Jingbo Li, Luda Song, Jianing Zhu, Bo Jiang, Yukun Luo. Value of high-frame-rate contrast-enhanced ultrasound in evaluation of pseudocapsule sign in small clear cell renal carcinoma[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(11): 1114-1118.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2023.11.002

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References 22

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观察者B	观察者A			合计
观察者B	完全可见	部分可见	完全不可见	合计
常规超声造影
完全可见	15（50.0）	1（3.3）	0（0）	16（53.3）
部分可见	3（10.0）	6（20.0）	3（10.0）	12（40.0）
完全不可见	0（0）	1（3.3）	1（3.3）	2（6.7）
合计	18（60.0）	8（26.7）	4（13.3）	30（100）
高帧频超声造影
完全可见	17（56.7）	1（3.3）	0（0）	18（60.0）
部分可见	2（6.6）	6（20.0）	1（3.3）	9（30.0）
完全不可见	0（0）	0（0）	3（10.0）	3（10.0）
合计	19（63.3）	7（23.3）	4（13.3）	30（100）

观察者B	观察者A			合计
观察者B	完全可见	部分可见	完全不可见	合计
常规超声造影
完全可见	15（50.0）	1（3.3）	0（0）	16（53.3）
部分可见	3（10.0）	6（20.0）	3（10.0）	12（40.0）
完全不可见	0（0）	1（3.3）	1（3.3）	2（6.7）
合计	18（60.0）	8（26.7）	4（13.3）	30（100）
高帧频超声造影
完全可见	17（56.7）	1（3.3）	0（0）	18（60.0）
部分可见	2（6.6）	6（20.0）	1（3.3）	9（30.0）
完全不可见	0（0）	0（0）	3（10.0）	3（10.0）
合计	19（63.3）	7（23.3）	4（13.3）	30（100）

观察者B	观察者A			合计
观察者B	完全可见	部分可见	完全不可见	合计
常规超声造影
完全可见	35（70.0）	0（0）	1（2.0）	36（72.0）
部分可见	3（6.0）	3（6.0）	2（4.0）	8（16.0）
完全不可见	0（0）	1（2.0）	5（10.0）	6（12.0）
合计	38（76.0）	4（8.0）	8（16.0）	50（100）
高帧频超声造影
完全可见	38（76.0）	0（0）	0（0）	38（76.0）
部分可见	0（0）	4（8.0）	2（4.0）	6（12.0）
完全不可见	1（2.0）	0（0）	5（10.0）	6（12.0）
合计	39（78.0）	4（8.0）	7（14.0）	50（100）

观察者B	观察者A			合计
观察者B	完全可见	部分可见	完全不可见	合计
常规超声造影
完全可见	35（70.0）	0（0）	1（2.0）	36（72.0）
部分可见	3（6.0）	3（6.0）	2（4.0）	8（16.0）
完全不可见	0（0）	1（2.0）	5（10.0）	6（12.0）
合计	38（76.0）	4（8.0）	8（16.0）	50（100）
高帧频超声造影
完全可见	38（76.0）	0（0）	0（0）	38（76.0）
部分可见	0（0）	4（8.0）	2（4.0）	6（12.0）
完全不可见	1（2.0）	0（0）	5（10.0）	6（12.0）
合计	39（78.0）	4（8.0）	7（14.0）	50（100）

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