Comparative study of the therapeutic effect between absolute alcohol and Lauromacrogol injection in ultrasound-guided treatment of thyroid cystic lesion

doi:10.3877/cma.j.issn.1672-6448.2015.09.013

Abstract

Abstract:

Objective

To investigate the efficiency and safety of absolute alcohol injection and lauromacrogol injection in ultrasound-guided sclerotherapy of thyroid cystic lesion.

Methods

There were 86 lesions in 83 patients of thyroid cystic lesion in absolute alcohol treatment group from February 2008 to February 2010. And there were 119 lesions in 102 patients of thyroid cystic lesion in lauromacrogol injection treatment group from June 2010 to January 2014. All cases were treated by percutaneous ultrasound-guided injection. Therapeutic effect and side effect were observed and the baseline data of all the patients were analyzed.

Results

All patients were followed up for 12 months or more, the cure rate was 91.9% (79/86) in absolute alcohol treatment group, while it was 89.1% (106/119) in lauromacrogol injection treatment group. There was no statistically significant difference between the two groups (Z=-0.886, P=0.376). The occurrence rate of neck discomfort in absolute alcohol treatment group was 32.5% (27/83), and it was 15.7% (16/102) in lauromacrogol injection treatment group. The difference was statistically significant (χ²=32.751, P<0.05). The occurrence rate of puncture-related needle-tract hemorrhage in absolute alcohol treatment group was 9.6% (8/83), and it was 2.0% (2/102) in lauromacrogol injection treatment group. The difference was statistically significant (P=0.045). The occurrence rate of intracystic hemorrhage in absolute alcohol treatment group was 4.8% (4/83), and it was 8.8% (9/102) in lauromacrogol injection treatment group. The difference was not statistically significant.

Conclusions

The therapeutic effect of lauromacrogol injection and absolute alcohol injection in treatment for thyroid cystic lesion is similar, but the side effect is significantly less than the latter one. So lauromacrogol injection is safer than the absolute alcohol injection.

Key words: Absolute alcohol, Lauromacrogol injection, Ultrasonography, interventional, Sclerotherapy, Thyroid diseases

Jidong Chen, Linxian Yue, Chao Feng, Yanqun Xiong, Qin Chen, Jun Luo, Hao Wu. Comparative study of the therapeutic effect between absolute alcohol and Lauromacrogol injection in ultrasound-guided treatment of thyroid cystic lesion[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2015, 12(09): 734-738.

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组别	例数	年龄（岁，±s）	性别（例，男性/女性）	病程（月，±s）	囊肿体积（ml，±s）
无水乙醇治疗组	83	45.81±15.34	18/65	17.00±8.32	8.2
聚桂醇注射液治疗组	102	46.04±14.78	21/81	18.71±8.73	8.5
检验值		t=0.38	χ²=2.04	t =0.10	Z=0.41
P值		>0.05	>0.05	>0.05	>0.05

组别	例数	年龄（岁，±s）	性别（例，男性/女性）	病程（月，±s）	囊肿体积（ml，±s）
无水乙醇治疗组	83	45.81±15.34	18/65	17.00±8.32	8.2
聚桂醇注射液治疗组	102	46.04±14.78	21/81	18.71±8.73	8.5
检验值		t=0.38	χ²=2.04	t =0.10	Z=0.41
P值		>0.05	>0.05	>0.05	>0.05

组别	病灶个数	疗效
组别	病灶个数	0级	Ⅰ级	Ⅱ级	Ⅲ级
无水乙醇治疗组	86	0	2（2.3）	5（5.8）	79（91.9）
聚桂醇注射液治疗组	119	0	5（4.2）	8（6.7）	106（89.1）
Z值	-0.458
P值	0.647

组别	病灶个数	疗效
组别	病灶个数	0级	Ⅰ级	Ⅱ级	Ⅲ级
无水乙醇治疗组	86	0	2（2.3）	5（5.8）	79（91.9）
聚桂醇注射液治疗组	119	0	5（4.2）	8（6.7）	106（89.1）
Z值	-0.458
P值	0.647

组别	例数	患侧不适	针道出血	囊内出血	醉酒样反应
无水乙醇治疗组	83	27（32.5）	8（9.6）	4（4.8）	7（8.4）
聚桂醇注射液治疗组	102	16（15.7）	2（2.0）	9（8.8）	0（0）
χ²值		32.751	–	7.063	–
P值		<0.001	0.045^a	0.008	0.003^a

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