Value of dynamic three-dimensional contrast-enhanced ultrasonography in evaluating therapeutic response of hepatoma treated with radiofrequency ablation

doi:10.3877/cma.j.issn.1672-6448.2017.03.007

Abstract

Abstract:

Objective

To investigate the value of dynamic three-dimensional contrast-enhanced ultrasound (3D-CEUS) in evaluating therapeutic response of hepatoma treated with radiofrequency ablation (RFA).

Methods

Totally 48 cases of patients with hepatic carcinoma (48 lesions) admitted in Xiangya Hospital of Central South University from September 2012 to January 2014 were selected. All patients underwent radiofrequency ablation, of which 30 patients were diagnosed by pathology after surgery, 18 patients by clinical diagnosis. All patients underwent two-dimensional contrast-enhanced ultrasound (2D-CEUS) and 3D-CEUS 1 month and 3 months after RFA treatment to evaluate the therapeutic response, and the results of contrast-enhanced ultrasound and enhanced computed tomography (CT) [or magnetic resonance imaging (MRI)] were compared . The final diagnostic results of pathologic biopsy or more than two imaging examinations [ultrasonography, CT, MRI, positron emission tomography (PET)], tumor markers, and more than 3 months follow-up of patients were used as the gold standard. The sensitivity, specificity and accuracy of dynamic 3D-CEUS, 2D-CEUS, enhanced CT (or MRI) in the diagnosis of tumor inactivation were calculated respectively.

Results

After radiofrequency ablation, dynamic 3D-CEUS could provide more valuable information in 75.0% (36/48) lesions, which contribute to assess the efficacy of radiofrequency ablation. While compared with 2D-CEUS, 3D-CEUS did not change the diagnosis or clinical management in 12 (25.0%) lesions. 40 of 48 lesions were found no-enhancement in entire CEUS procedure suggesting that the tumor completely inactivated, while 8 lesions showed local enhancement on the edge of lesion suggesting that part of the tumors were active. 39 of 48 lesions showed no-enhancement and other 9 with irregular enhancement on enhanced CT (or MRI). The sensitivity, specificity and accuracy of CEUS and enhanced CT (or MRI) in detection of residual tumor after radiofrequency ablation were 80.0%, 100%, 95.8% and 80.0%, 97.4%, 93.8%, respectively.

Conclusions

There was no statistical significance among 3D-CEUS, 2D-CEUS and enhanced CT or MRI in evaluating therapeutic response of hepatoma treated with radiofrequency ablation. But 3D-CEUS can provide more valuable information, 3D-CEUS has potential usefulness in the evaluation of percutaneous radiofrequency ablation of hepatic tumors..

Key words: Liver neoplasms, Ultrasonography, Contrast media, Ablation techniques, Treatment outcome

Luyang Chen, Jintan Liao, Wenjun Qi, Bo Zhang, Qin Jiang, Ruizhe Pan, Shuchu Wang, Wenzheng Li, Xueying Long. Value of dynamic three-dimensional contrast-enhanced ultrasonography in evaluating therapeutic response of hepatoma treated with radiofrequency ablation[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2017, 14(03): 193-199.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2017.03.007

https://chaosheng.cma-cmc.com.cn/EN/Y2017/V14/I03/193

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References 17

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检查方法		最终诊断		合计
检查方法		肿瘤部分残存	肿瘤灭活	合计
CEUS		?	?	?
?	肿瘤部分残存	8	0	8
?	肿瘤灭活	2	38	40
增强CT或MRI		?	?	?
?	肿瘤部分残存	8	1	9
?	肿瘤灭活	2	37	39

检查方法		最终诊断		合计
检查方法		肿瘤部分残存	肿瘤灭活	合计
CEUS		?	?	?
?	肿瘤部分残存	8	0	8
?	肿瘤灭活	2	38	40
增强CT或MRI		?	?	?
?	肿瘤部分残存	8	1	9
?	肿瘤灭活	2	37	39

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