Effects of carotid shear rate on carotid intima-media thickness in kidney transplant recipients

doi:10.3877/cma.j.issn.1672-6448.2017.06.010

Abstract

Abstract:

Objective

To analyze the relation between carotid intima-media thickness (IMT) and the shear rate (SR), and to explore the effect of SR on IMT in the patients with end-stage renal disease (ESRD) and the kidney transplant recipients (KTR).

Methods

From March 2014 to December 2015, 31 KTR and 31 patients with ESRD supported by hemodialysis and 84 control subjects underwent an carotid ultrasound in Shanghai General Hospital affiliated to Shanghai Jiaotong University. Bilateral carotid IMT and SR were measured. The differences of IMT and SR in three groups were compared by single factor analysis of variance. SNK-q test was used to compare the two groups. The correlation between SR and bilateral IMT was analyzed by linear regression analysis in healthy control group, ESRD group and KTR group.

Results

On the right, in ESRD, KTR and control group, the IMTs were (561.9±147.7) μm, (480.5±90.3) μm and (529.7±131.80) μm respectively. Compared with KTR and control group, the IMT on right was thickest in ESRD, but there was no significant difference between KTR and control group in right IMT. On the left, the IMTs were (517.5±164.7) μm, (506.7±126.3) μm and (467.0±106.4) μm in control group, ESRD and KTR, respectively. Among groups, there was no significant difference. On the right, the SRs were (134.01±56.4) s^-1, (133.4±43.7) s^-1 and (175.8±68.3) s^-1 in ESRD, KTR and control group, respectively. In ESRD and KTR groups, the SR of the right carotid artery was less than that of the control group, and had significant difference (q=3.133, P=0.002; q=3.470, P<0.001). There was no significant difference in right SR between ESRD and KTR. On the left, the SRs were (146.3±55.9) s^-1, (138.5±43.8) s^-1 and (154.7±60.8) s^-1 in ESRD, KTR and control group, respectively, and had no significant difference. There was linear negative correlation between SR and IMT in healthy control group, ESRD group and KTR group, respectively (right: r=-0.384, -0.082, -0.454; left: r=-0.572, 0.223, -0.276, all P<0.05).

Conclusions

The IMT was thickened in ESRD group, but got thinning after successful kidney transplantation. The SR played a vital role in this alteration of IMT.

Key words: Kidney transplantation, Nephrosis, Carotid arteries, Intima-media thickness, Shear rate

Zhaojun Li, Fan Li, Yan Qin, Qian Zhang, Feng Gao, Lianfang Du, Xianghong Luo. Effects of carotid shear rate on carotid intima-media thickness in kidney transplant recipients[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2017, 14(06): 446-451.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2017.06.010

https://chaosheng.cma-cmc.com.cn/EN/Y2017/V14/I06/446

Figures/Tables 3

References 19

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组别	例数	性别（男性/女性，例）	年龄（岁，±s）	身高（cm，±s）	体重（kg，±s）	收缩压（mmHg，±s）	舒张压（mmHg，±s）
健康对照组	84	55/29	43.1±19.9	166.7±6.5	63.6±9.2	119.3±15.8^b	77.1±8.3^c
ESRD组	31	20/11	50.3±17.9	163.3±7.3	64.2±12.1	146.9±21.3	86.9±13.5^d
肾移植组	31	22/9	47.9±14.3	163.5±7.7	56.0±13.3^a	145.8±13.5	94.3±8.6
检验值	?	χ²=2.355	F=1.986	F=3.038	F=6.018	F=45.588	F=37.863
P值	?	0.317	0.141	0.051	0.003	<0.001	<0.001
组别	例数	FPG（mmol/L，±s）	TC（mmol/L，±s）	TG（mmol/L，±s）	LDL（mmol/L，±s）	HDL（mmol/L，±s）
健康对照组	84	5.3±1.1	6.0±1.2	1.4±0.7	3.1±0.9	1.2±0.3
ESRD组	31	4.6±0.6	4.9±1.2	1.9±0.9	2.7±0.9	1.3±0.3
肾移植组	31	4.9±0.7	4.5±0.8	1.4±0.3	2.3±0.6	1.4±0.3
检验值	?	F=1.420	F=1.142	F=1.072	F=1.511	F=0.978
P值	?	0.245	0.322	0.345	0.224	0.432

组别	例数	性别（男性/女性，例）	年龄（岁，±s）	身高（cm，±s）	体重（kg，±s）	收缩压（mmHg，±s）	舒张压（mmHg，±s）
健康对照组	84	55/29	43.1±19.9	166.7±6.5	63.6±9.2	119.3±15.8^b	77.1±8.3^c
ESRD组	31	20/11	50.3±17.9	163.3±7.3	64.2±12.1	146.9±21.3	86.9±13.5^d
肾移植组	31	22/9	47.9±14.3	163.5±7.7	56.0±13.3^a	145.8±13.5	94.3±8.6
检验值	?	χ²=2.355	F=1.986	F=3.038	F=6.018	F=45.588	F=37.863
P值	?	0.317	0.141	0.051	0.003	<0.001	<0.001
组别	例数	FPG（mmol/L，±s）	TC（mmol/L，±s）	TG（mmol/L，±s）	LDL（mmol/L，±s）	HDL（mmol/L，±s）
健康对照组	84	5.3±1.1	6.0±1.2	1.4±0.7	3.1±0.9	1.2±0.3
ESRD组	31	4.6±0.6	4.9±1.2	1.9±0.9	2.7±0.9	1.3±0.3
肾移植组	31	4.9±0.7	4.5±0.8	1.4±0.3	2.3±0.6	1.4±0.3
检验值	?	F=1.420	F=1.142	F=1.072	F=1.511	F=0.978
P值	?	0.245	0.322	0.345	0.224	0.432

组别	例数	颈动脉IMT（μm）		CCAD（mm）		SR（s^-1）
组别	例数	右侧	左侧	右侧	左侧	右侧	左侧
健康对照组	84	529.7±131.8	517.5±164.7	7.53±1.38	7.65±1.53	175.8±68.3^d	154.7±60.8
ESRD组	31	561.9±147.7^a	506.7±126.3	9.12±2.39^b	9.00±2.36^c	134.01±56.4	146.3±55.9
肾移植组	31	480.5±90.3	467.0±106.4	7.64±1.10	7.65±0.94	133.4±43.7	138.5±43.8
检验值	?	3.169	1.248	9.863	7.975	7.872	0.941
P值	?	0.045	0.290	<0.001	<0.001	<0.001	0.393

组别	例数	颈动脉IMT（μm）		CCAD（mm）		SR（s^-1）
组别	例数	右侧	左侧	右侧	左侧	右侧	左侧
健康对照组	84	529.7±131.8	517.5±164.7	7.53±1.38	7.65±1.53	175.8±68.3^d	154.7±60.8
ESRD组	31	561.9±147.7^a	506.7±126.3	9.12±2.39^b	9.00±2.36^c	134.01±56.4	146.3±55.9
肾移植组	31	480.5±90.3	467.0±106.4	7.64±1.10	7.65±0.94	133.4±43.7	138.5±43.8
检验值	?	3.169	1.248	9.863	7.975	7.872	0.941
P值	?	0.045	0.290	<0.001	<0.001	<0.001	0.393

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