Correlation of arterial total compliance and carotid-femoral pulse wave velocity: an echocardiographic study

doi:10.3877/cma.j.issn.1672-6448.2017.09.008

Abstract

Abstract:

Objective

To explore the correlation between arterial total compliance indices, stroke volume/pulse pressure (SV/PP), SV adjusted by body surface area/PP (SV′/PP) and carotid-femoral pulse wave velocity (PWV), and investigate the value of SV/PP, SV′/PP in the evaluation of clinical arterial stiffness (AS).

Methods

Forty-five hospitalized patients with coronary heart disease (CHD) in Tangdu Hospital of Fourth Military Medical University from March to December 2016 were included in this study (CHD group). Forty-five healthy volunteers who took a health checkup in Tangdu Hospital at the same period were also included as healthy controls. SV was measured by echocardiography, and the PP was calculated through traditional blood pressure measurement. Body surface area was calculated by Du Bois formula. Carotid-femoral PWV was measured by Doppler ultrasonography. Unpaired t test was used to compare the AS indices between CHD group and healthy controls. Spearman correlation analysis was used to evaluate the correlation between SV/PP, SV′/PP and carotid-femoral PWV.

Results

SV/PP, SV′/PP were decreased [(1.23±0.26) ml/mmHg vs (1.37±0.27) ml/mmHg, (0.66±0.13) ml/m²?mmHg vs (0.74±0.15) ml/m²?mmHg, 1 mmHg=0.133 kPa], carotid-femoral PWV was increased [(9.49±2.05) m/s vs (8.16±1.07) m/s] in CHD patients when compared with control group with statistical significance (t=2.0971, P<0.05; t=2.1643, P<0.05; t=2.8321, P<0.01, respectively). Both SV/PP and SV′/PP in healthy controls and CHD group inversely correlated with the corresponding Carotid-femoral PWV (healthy controls: r=-0.64, -0.56, both P<0.001; CHD group: r=-0.53, P=0.0002, r=0.61, P<0.001). While SV′/PP showed a stronger correlation with carotid-femoral PWV.

Conclusions

Arterial total compliance decreases and AS increases in CHD patients compared with healthy controls. SV/PP, derived from echocardiography and blood pressure measurement, correlates with carotid-femoral PWV, the ″golden standard″ index of AS. After adjusted by body surface area, SV′/PP correlates more strongly with carotid-femoral PWV. SV/PP and SV′/PP are expected to provide a simple and convenient way for clinical noninvasive AS evaluation.

Key words: Echocardiography, Arterial compliance, Pulse wave velocity, Arterial stiffness, Stroke volume/pulse pressure

Yutong Liang, Yong Yang, Pengfei Chen, Tian Zhou, Zhen Wang. Correlation of arterial total compliance and carotid-femoral pulse wave velocity: an echocardiographic study[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2017, 14(09): 671-675.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2017.09.008

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References 16

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组别	例数	年龄（岁）	身高（cm）	体重（kg）	体表面积（m²）	体重指数（kg/m²）	收缩压（mmHg）	舒张压（mmHg）
冠心病组	45	47.0±11.0	172.5±8.7	74.5±7.6	1.878±0.12	25.1±3.1	135.4±16.6	77.7±9.9
健康对照组	45	46.6±10.9	173.4±8.6	72.7±6.8	1.865±0.11	24.2 ±3.1	127.6±14.8	78.8±9.8
t值	?	0.4492	1.3897	1.4461	1.6824	1.8466	2.1377	1.6998
P值	?	0.654	0.133	0.125	0.095	0.087	<0.05	0.102
组别	例数	心率（次/min）	总胆固醇（mmol/L）	甘油三酯（mmol/L）	HDLC（mmol/L）	LDLC（mmol/L）	空腹血糖（mmol/L）	LVEF（%）
冠心病组	45	70.3±9.1	5.38±1.11	1.31±0.53	1.09±0.19	2.99±0.60	5.28±0.79	58±11
健康组	45	71.7±9.2	4.82±0.79	1.17±0.51	1.13±0.21	2.92±0.57	5.12±0.70	60±12
t值	?	0.8879	2.1566	2.1374	1.4479	1.4083	1.1094	1.3829
P值	?	0.312	<0.05	<0.05	0.124	0.129	0.261	0.134

组别	例数	年龄（岁）	身高（cm）	体重（kg）	体表面积（m²）	体重指数（kg/m²）	收缩压（mmHg）	舒张压（mmHg）
冠心病组	45	47.0±11.0	172.5±8.7	74.5±7.6	1.878±0.12	25.1±3.1	135.4±16.6	77.7±9.9
健康对照组	45	46.6±10.9	173.4±8.6	72.7±6.8	1.865±0.11	24.2 ±3.1	127.6±14.8	78.8±9.8
t值	?	0.4492	1.3897	1.4461	1.6824	1.8466	2.1377	1.6998
P值	?	0.654	0.133	0.125	0.095	0.087	<0.05	0.102
组别	例数	心率（次/min）	总胆固醇（mmol/L）	甘油三酯（mmol/L）	HDLC（mmol/L）	LDLC（mmol/L）	空腹血糖（mmol/L）	LVEF（%）
冠心病组	45	70.3±9.1	5.38±1.11	1.31±0.53	1.09±0.19	2.99±0.60	5.28±0.79	58±11
健康组	45	71.7±9.2	4.82±0.79	1.17±0.51	1.13±0.21	2.92±0.57	5.12±0.70	60±12
t值	?	0.8879	2.1566	2.1374	1.4479	1.4083	1.1094	1.3829
P值	?	0.312	<0.05	<0.05	0.124	0.129	0.261	0.134

组别	例数	PP（mmHg）	SV（ml）	SV/PP（ml/mmHg）	SV′/PP（ml/m²?mmHg）	颈-股PWV（m/s）
冠心病组	45	57.8±10.2	71±8.4	1.23±0.26	0.66±0.13	9.49±2.05
健康对照组	45	48.8±10.0	67±8.6	1.37±0.27	0.74±0.15	8.16±1.07
t值	?	2.1656	2.1840	2.0971	2.1643	2.8321
P值	?	<0.05	<0.05	<0.05	<0.05	<0.01

组别	例数	PP（mmHg）	SV（ml）	SV/PP（ml/mmHg）	SV′/PP（ml/m²?mmHg）	颈-股PWV（m/s）
冠心病组	45	57.8±10.2	71±8.4	1.23±0.26	0.66±0.13	9.49±2.05
健康对照组	45	48.8±10.0	67±8.6	1.37±0.27	0.74±0.15	8.16±1.07
t值	?	2.1656	2.1840	2.0971	2.1643	2.8321
P值	?	<0.05	<0.05	<0.05	<0.05	<0.01

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