Evaluation of the development of neonatal corpus callosum and the influencing factors by ultrasonography

doi:10.3877/cma.j.issn.1672-6448.2018.07.011

Abstract

Abstract:

Objective

To analyze the influencing factors of the development of corpus callosum in newborns through monitoring the growth rate of the corpus callosum by ultrasonography.

Methods

The study included 97 cases of newborns who were admitted in Lanzhou University Second Hospital neonatal intensive care unit (NICU) from April 2016 to December 2016. Of them, there were 54 premature infants (27-34 w) and 43 term infants. The sagittal length of corpus callosum was measured by ultrasonography per week at 0-6 w of age. The growth rate of corpus callosum was compared between preterm infants and term infants by independent sample t test. The relationships between gestational age, neonatal birth weight and corpus callosum growth rate were analyzed.

Results

(1) The sagittal length of the corpus callosum in newborns were correlated with gestational age and birth weight (r=0.57, 0.58). (2) The length of corpus callosum at 0 weeks, 2 weeks, 3 weeks, 4 weeks, 5 weeks and 6 weeks after birth was lower than that of term infants (t=6.22, 6.51, 7.81, 8.87, 10.25, 11.64, all P<0.01). (3) There was no significant difference in the growth rate of corpus callosum between preterm and term infants at 0-2 weeks after birth (P>0.05). The growth rate of corpus callosum was significantly different between preterm and term infants at 2-6 weeks after birth (t=13.91, 14.76, 13.85, 12.21, all P<0.01).

Conclusions

The development of the corpus callosum is related to gestational age and birth weight. Cranial ultrasound can dynamically monitor the growth and development of the corpus callosum.

Key words: Cranial ultrasound, Corpus callosum, Premature children, Brain injury

Jing Li, Fang Nie, Jiaqi Wei, Tiantian Dong, Lan Bu, Yanfang Wang, Qi Li, Dan Yang. Evaluation of the development of neonatal corpus callosum and the influencing factors by ultrasonography[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2018, 15(07): 530-533.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2018.07.011

https://chaosheng.cma-cmc.com.cn/EN/Y2018/V15/I07/530

Figures/Tables 3

References 17

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组别		例数	新生儿出生时间（周）
组别		例数	0	2	3	4	5	6
早产儿		?	?	?	?	?	?	?
?	27~30孕周	9	35.20±3.45	35.32±2.86	36.14±2.93	36.88±2.88	37.67±2.90	38.53±2.78
?	31~32孕周	16	36.41±3.00	37.64±1.75	38.43±1.80	39.24±1.82	39.98±1.81	40.97±1.89
?	33~34孕周	29	37.90±3.10	39.13±3.36	40.04±3.35	40.98±3.38	41.93±3.36	42.75±3.40
足月儿（≥37孕周）		43	40.88±2.55	41.95±2.58	43.56±2.51	45.12±2.52	46.78±2.42	48.47±2.40
t值		?	6.22	6.51	7.81	8.87	10.25	11.64
P值		?	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

组别		例数	新生儿出生时间（周）
组别		例数	0	2	3	4	5	6
早产儿		?	?	?	?	?	?	?
?	27~30孕周	9	35.20±3.45	35.32±2.86	36.14±2.93	36.88±2.88	37.67±2.90	38.53±2.78
?	31~32孕周	16	36.41±3.00	37.64±1.75	38.43±1.80	39.24±1.82	39.98±1.81	40.97±1.89
?	33~34孕周	29	37.90±3.10	39.13±3.36	40.04±3.35	40.98±3.38	41.93±3.36	42.75±3.40
足月儿（≥37孕周）		43	40.88±2.55	41.95±2.58	43.56±2.51	45.12±2.52	46.78±2.42	48.47±2.40
t值		?	6.22	6.51	7.81	8.87	10.25	11.64
P值		?	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

组别	例数	0~6周新生儿胼胝体生长率
组别	例数	0~2周	2~3周	3~4周	4~5周	5~6周
早产儿	54	1.06±0.29	0.85±0.24	0.87±0.23	0.88±0.28	0.88±0.20
足月儿	43	1.07±0.25	1.61±0.31	1.56±0.23	1.67±0.26	1.69±0.43
t值	?	0.26	13.61	14.76	13.85	12.21
P值	?	0.80	<0.001	<0.001	<0.001	<0.001

组别	例数	0~6周新生儿胼胝体生长率
组别	例数	0~2周	2~3周	3~4周	4~5周	5~6周
早产儿	54	1.06±0.29	0.85±0.24	0.87±0.23	0.88±0.28	0.88±0.20
足月儿	43	1.07±0.25	1.61±0.31	1.56±0.23	1.67±0.26	1.69±0.43
t值	?	0.26	13.61	14.76	13.85	12.21
P值	?	0.80	<0.001	<0.001	<0.001	<0.001

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