Clinical value of virtual touch tissue imaging quantification in diagnosing salivary gland Sjögren's syndrome

doi:10.3877/cma.j.issn.1672-6448.2021.01.004

Abstract

Abstract:

Objective

To assess the value of virtual touch tissue imaging quantification (VTIQ) in the diagnosis of Sj?gren's syndrome (SS).

Methods

Totally 50 patients with Sj?gren's syndrome (experimental group) and 60 healthy volunteers (control group) were enrolled at Lanzhou University Second Hospital from November 2018 to December 2019. VTIQ technology was performed on bilateral parotid and submandibular glands to obtain shear wave velocity (SWV) value, which was compared between the two groups by t test. ROC curves were drawn to obtain the best cut-off value of SWV and estimate the role of VTIQ in the diagnosis of SS. The difference of SWV was also compared between primary and secondary SS by t test.

Results

SWV values of the parotid gland and submandibular gland in the experimental group were statistically higher than those of the control group [(2.39±0.31) m/s vs (1.94±0.22) m/s, t=12.13, P＜0.001; (2.42±0.33) m/s vs (2.14±0.29) m/s, t=6.82, P＜0.001)]. The optimal cut-off values to diagnose SS in the parotid gland and submandibular gland were 2.035 m/s and 2.115 m/s, respectively. In the parotid gland, the SWV value of primary SS was statistically higher than that of secondary SS [(2.46±0.36) m/s vs (2.27±0.16) m/s, t=3.68, P＜0.001], but there was no statistical difference in the submandibular gland [(2.37±0.31) m/s vs (2.50±0.34) m/s, P＞0.05].

Conclusion

VTIQ technology can quantitatively show the tissue hardness changes in the salivary gland of SS patients. There is a certain difference in the hardness of salivary gland tissue between primary and secondary SS patients. VTIQ technology has high clinical value in the diagnosis of SS.

Key words: Sj?gren's syndrome, Virtual touch tissue imaging quantification, Parotid gland, Submandibular gland

Yanqing Wang, Fang Nie, Longli Wang, Yangyang Zhu, Yuting Tan. Clinical value of virtual touch tissue imaging quantification in diagnosing salivary gland Sjögren's syndrome[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2021, 18(01): 11-16.

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Figures/Tables 8

References 30

1	Mariette X, Criswell LA. Primary Sjögren's syndrome [J]. N Engl J Med, 2018, 378(10): 931-939.
2	Fisher BA, Jonsson R, Daniels T, et al. Standardisation of labial salivary gland histopathology in clinical trials in primary Sjögren's syndrome [J]. Ann Rheum Dis, 2016, 76(7): 1161-1168.
3	Vera M, Radmila P, Ivan B, et al. Ultrasonography of major salivary glands could be an alternative tool to sialoscintigraphy in the American-European classification criteria for primary Sjögren's syndrome [J]. Rheumatology (Oxford), 2012, 51(6): 1081-1085.
4	Baldini C, Luciano N, Tarantini G, et al. Salivary gland ultrasonography: a highly specific tool for the early diagnosis of primary Sjögren's syndrome [J]. Arthritis Res Ther, 2015, 17(1): 146.
5	Cornec, D, Jousse-Joulin S, Marhadour T, et al. Salivary gland ultrasonography improves the diagnostic performance of the 2012 American College of Rheumatology classification criteria for Sjögren's syndrome [J]. Rheumatology (Oxford), 2014, 53(9): 1604-1607.
6	Hocevar A. Ultrasonographic changes of major salivary glands in primary Sjögren's syndrome. Diagnostic value of a novel scoring system [J]. Rheumatology (Oxford), 2005, 44(6): 768-772.
7	吴松年, 何建娣, 蒋天安, 等. 声触诊组织成像量化技术鉴别诊断甲状腺TI-RADS 4类结节的临床研究 [J]. 中华超声影像学杂志, 2016, 25(7): 573-578.
8	Liu H, Wan J, Xu G, et al. Conventional US and 2-D shear wave elastography of virtual touch tissue imaging quantification: correlation with immunohistochemical subtypes of breast cancer [J]. Ultrasound Med Biol, 2019, 45(10): 2612‐2622.
9	Daniels TE, Fox PC, Fox RI, et al. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group [J]. Ann Rheum Dis, 2002, 61(6): 554-558.
10	Maślińska M, Przygodzka M, Kwiatkowska B, et al. Sjogren's syndrome: still not fully understood disease [J]. Rheumatol Int, 2015, 35(2): 233-241.
11	Horvath S, Nazmul-Hossain ANM, Pollard RPE, et al. Systems analysis of primary Sjogren's syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model [J]. Arthritis Res Ther, 2012, 14(6): R238.
12	Delli K, Arends S, van Nimwegen JF, et al. Ultrasound of the major salivary glands is a reliable imaging technique in patients with clinically suspected primary Sjögren's syndrome [J]. Ultraschall Med, 2018, 39(3): 328-333.
13	Nimwegen JFV, Mossel E, Delli K, et al. Incorporation of salivary gland ultrasonography into the America College of Rheumatology/European League Against Rheumatism Criteria for primary Sjögren's syndrome [J]. Arthritis Care Res (Hoboken), 2020, 72(4): 583-590.
14	Fisher BA, Everett CC, Rout J, et al. Effect of rituximab on a salivary gland ultrasound score in primary Sjögren's syndrome: results of the TRACTISS randomised double-blind multicentre substudy [J]. Ann Rheum Dis, 2018, 77(3): 412-416.
15	Takagi Y, Sumi M, Nakamura H, et al. Ultrasonography as an additional item in the American College of Rheumatology classification of Sjögren's syndrome [J]. Rheumatology (Oxford), 2014, 53(11): 1977-1983.
16	Sheng-Hung C, Hsueh-Chou L, I-Ping C, et al. Performance of acoustic radiation force impulse elastography for staging liver fibrosis in patients with chronic hepatitis c after viral eradication [J]. Clin Infect Dis, 2020, 70(1): 114-122.
17	Ma Y, Zhang S, Li J, et al. Comparison of strain and shear-wave ultrasounic elastography in predicting the pathological response to neoadjuvant -chemotherapy in breast cancers [J]. Eur Radiol, 2017, 27(6): 2282-2291.
18	田锦, 武雅婷, 柯青兰, 等. 声触诊组织量化技术诊断干燥综合征涎腺病变的价值 [J]. 中国超声医学杂志, 2019, 35(9): 769-772.
19	杨芦莎, 张群霞, 王志刚, 等. 声辐射力脉冲弹性成像诊断干燥综合征涎腺病变 [J]. 中国医学影像技术, 2018, 34(10): 1474-1478.
20	Zhang S, Zhu J, Zhang X, et al. Assessment of the stiffness of major salivary glands in primary Sjögren's syndrome through quantitative acoustic radiation force impulse imaging [J]. Ultrasound Med Biol, 2016, 42(3): 645-653.
21	Pereira D, Vilela V, Dos Santos T, et al. Clinical and laboratorial profile and histological features on minor salivary glands from patients under investigation for Sjögren's syndrome [J]. Med Oral Patol Oral Cir Bucal, 2014, 19(3): e237-e241.
22	Costa S, Quintin-Roué I, Lesourd A, et al. Reliability of histopathological salivary gland biopsy assessment in Sjögren's syndrome: a multicentre cohort study [J]. Rheumatology (Oxford), 2015, 54(6): 1056-1064.
23	王健楠, 王学梅, 欧国成. 超声弹性成像在干燥综合征诊断中的应用价值 [J]. 中国超声医学杂志, 2013, 29(1): 10-13.
24	Vivino F, Bunya VY, Massaro-Giordano G, et al. Sjogren's syndrome: an update on disease pathogenesis, clinical manifestations and treatment [J]. Clin Immunol, 2019, 203: 81-121.
25	谭飞, 赖维, 王海俊, 等. 原发性和继发性干燥综合征67例临床分析 [J]. 临床皮肤科杂志, 2010, 39(2): 80-82.
26	Streckfus C, Bigler L, Navazesh M, et al. Cytokine concentrations in stimulated whole saliva among patients with primary Sjögren's syndrome, secondary Sjögren's syndrome, and patients with primary Sjögren's syndrome receiving varying doses of interferon for symptomatic treatment of the condition: a preliminary study [J]. Clin Oral Investig, 2001, 5(2): 133-135. URL
27	Pia L, Juan BM, Frank B, et al. Is sonoelastography a helpful method of evaluation to diagnose Sjögren's syndrome? [J]. Int J Rheum Dis, 2019, 22(2): 175-181.
28	Giuseppetti GM, Argalia G, Salera D, et al. Ultrasonographic contrast-enhanced study of sicca syndrome [J]. Eur J Radiol, 2005, 54(2): 225-232.
29	Knopf A, Hofauer B, Thürmel K, et al. Diagnostic utility of Acoustic Radiation Force Impulse (ARFI) imaging in primary Sjoegren's syndrome [J]. Eur Radiol, 2015, 25(10): 3027-3034.
30	Samier-Guérin A, Saraux A, Gestin S, et al. Can ARFI elastometry of the salivary glands contribute to the diagnosis of Sjögren's syndrome? [J]. Joint Bone Spine, 2015, 83(3): 301-306.

侧别	试验组（50例）		对照组（60名）
侧别	腮腺	颌下腺	腮腺	腮腺
左侧	2.41±0.34	2.45±0.31	1.94±0.21	2.14±0.27
右侧	2.36±0.26	2.39±0.34	1.94±0.24	2.15±0.31
t值	1.39	1.57	－0.78	－0.49
P值	0.171	0.124	0.983	0.627

侧别	试验组（50例）		对照组（60名）
侧别	腮腺	颌下腺	腮腺	腮腺
左侧	2.41±0.34	2.45±0.31	1.94±0.21	2.14±0.27
右侧	2.36±0.26	2.39±0.34	1.94±0.24	2.15±0.31
t值	1.39	1.57	－0.78	－0.49
P值	0.171	0.124	0.983	0.627

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