To evaluate the value of tissue motion tracking of mitral annular displacement (TMAD) in predicting the prognosis of patients with coronavirus disease 2019 (COVID-19).

A total of 104 COVID-19 patients admitted to Union Hospital of Tongji Medical College, Huazhong University of Science and Technology from January 29, 2020 to March 4, 2020 were retrospectively included. According to the outcome, they were divided into either a death group (18 patients) or a survival group (86 patients). All patients underwent bedside echocardiography. Left ventricular ejection fraction (LVEF), left ventricular global longitudinal strain (LVGLS), mitral annular displacement (MAD), and mitral annular displacement rate (%MAD) were measured, and the differences in parameters between the two groups were compared. The cutoff values of MAD and %MAD for predicting adverse outcome were obtained based on the ROC curve, and the ability of MAD and %MAD to predict death was evaluated with a logistic regression model.

Compared with the survival group, the absolute values of LVGLS, MAD, and %MAD were significantly lower in the death group. The areas under the ROC curves of LVGLS, MAD, and %MAD were 0.777, 0.622, and 0.669, respectively (P＜0.05). The cutoff values of LVGLS, MAD, and %MAD were -17.9%, 12.0mm, and 14.6%, respectively, with a sensitivity of 93.8%, 75.0%, and 75.0%, and specificity of 62.3%, 50.7%, and 55.8%, respectively. Univariate logistic regression showed that MAD (odds ratio [OR]=3.500, P＜0.05) and %MAD (OR=4.421, P＜0.05) can predict the risk of death in patients with COVID-19.

MAD and %MAD are significantly related to the prognosis of COVID-19 patients, and the reductions of MAD and %MAD are risk factors for high mortality risk in COVID-19 patients. The measurement of TMAD is simple and convenient, which makes it be of great value in clinical application.