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中华医学超声杂志(电子版) ›› 2016, Vol. 13 ›› Issue (10) : 740 -745. doi: 10.3877/cma.j.issn.1672-6448.2016.10.006

所属专题: 文献

心血管超声影像学

四维面积应变评价不同左心室构型高血压患者的左心室功能
沈根松1,(), 徐丽萍1, 吴大利1   
  1. 1. 311106 浙江省杭州市余杭中医院超声科
  • 收稿日期:2016-03-29 出版日期:2016-10-01
  • 通信作者: 沈根松

The evaluation of left ventricular function in hypertension patients with different left ventricular configuration by four-demensional imaging area strain

Gensong Shen1,(), Liping Xu1, Dali Wu1   

  1. 1. Department of Ultrasound, the Hospital of Traditional Chinese Medicine of Yuhang, Hangzhou 311106, China
  • Received:2016-03-29 Published:2016-10-01
  • Corresponding author: Gensong Shen
  • About author:
    Corresponding author: Shen Gensong, Email:
引用本文:

沈根松, 徐丽萍, 吴大利. 四维面积应变评价不同左心室构型高血压患者的左心室功能[J]. 中华医学超声杂志(电子版), 2016, 13(10): 740-745.

Gensong Shen, Liping Xu, Dali Wu. The evaluation of left ventricular function in hypertension patients with different left ventricular configuration by four-demensional imaging area strain[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2016, 13(10): 740-745.

目的

评价四维应变成像技术面积应变(4D-area strain)检测高血压不同左心室构型患者左心室收缩功能的价值。

方法

收集2015年2月至8月浙江省杭州市余杭中医院确诊的原发性高血压患者125例,根据Ganan分类法分为:正常构型组45例(A组)、向心性重构组25例(B组)、向心性肥厚组25例(C组)及离心性肥厚组30例(D组)。另选取本院体检中心40名健康人作为健康对照组(N组)。采用4D-area strain检测各组与健康对照组常规左心室收缩功能指标与整体面积应变(GAS)、节段面积应变(RAS)值,进行相互比较。组间整体面积应变与对应的节段面积应变比较采用多样本均数方差分析,多个均数间的两两比较采用LSD-t检验。

结果

(1)常规心功能:A、B、C、D及N组左心室舒张末期容积(EDV)、心搏量(SV)及心输出量(CO)测值比较,差异均无统计学意义(F =0.679、3.829、0.600,P均>0.05),收缩末期容积(ESV)、射血分数(EF)、球形指数(Spl)、舒张末期重量(EDMass)测值比较,差异均有统计学意义(F=3.829、6.596、2.653、2.604,P均<0.05);D组ESV测值与N、A、B、C组比较,差异有统计学意义(t =2.011、2.244、3.685、2.278,P均<0.05);B组ESV测值与N组比较,差异有统计学意义(t=2.170,P<0.05);B组EF测值与N、A、D组比较,差异有统计学意义(t =2.452、3.514、4.949,P均<0.05);D组EF测值与N、C组比较,差异有统计学意义(t=2.849、3.486,P均<0.05);D组SpI测值与N、A、B、C组比较,差异有统计学意义(t =2.854、2.941、3.200、2.979,P均<0.05);C组EDMass测值与N、A组比较,差异有统计学意义(t=2.170、2.087,P均<0.05);D组EDMass测值与A、B、N组比较,差异有统计学意义(t=2.668、2.081、3.762,P均<0.05)。(2)GAS:A、B、C、D各组与N组GAS测值比较,差异均有统计学意义(t=7.950、7.361、8.959、11.277,P均<0.01),且随左心室重构程度加重差异更为明显;A、B组GAS测值分别与D组比较,差异均有统计学意义(t =3.332、2.102,P均<0.05),A组GAS测值与C组比较,差异有统计学意义(t=3.134,P<0.05)。(3)RAS:D组所有节段与N组比较,差异均有统计学意义(第1~17节段,t分别为2.967、3.793、4.896、4.001、2.375、4.169、4.077、2.137、4.652、4.016、5.230、6.267、5.735、2.143、2.353、5.429、4.128,P均<0.05);A、B、C 3组与N组比较,基底段的前间隔壁、后间隔壁、前侧壁,中间段的前侧壁,心尖段的前壁、侧壁、心尖帽,差异均有统计学意义(A-N:t=2.667、3.084、3.574、4.771、3.182、4.806、3.567,P均<0.05;B-N:t=2.702、2.868、2.179、3.130、3.302、3.203、3.093,P均<0.05;C-N:t=4.927、5.600、4.276、6.577、6.198、5.190、5.441,P均<0.05);A、B、C 3组与N组心尖间隔段比较,差异均无统计学意义(t=0.934、1.562、1.879,P均>0.05)。

结论

4D-area strain为不同左心室构型高血压患者左心室收缩功能的检测提供一种新方法,尤其是对早期收缩功能的检测更为敏感。

Objective

To evaluate the left ventricular systolic function of different patients with hypertension by Four-demensional imaging area strain (4D-area strain).

Methods

Totally 125 hypertension patients and 40 normal subjects (group N) were enrolled. According to Ganan classification, hypertension patients were classified into normal geometry (groups A, n=45), concentric remodeling (group B, n=25), concentric hypertrophy (group C, n=25) and eccentric hypertrophy (group D, n=30). Parameters of left ventricular systolic function, including global area strain (GAS), regional area strain (RAS) and left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), cardiac output (CO), ejection fraction (EF), spherical index (Spl), end-diastolic weight (EDMass) were analyzed.

Results

There was no statistically significant difference among thegroups A, B, C, D, and N in left ventricular EDV, SV and CO (F=0.679, 3.829, 0.600, P>0.05). There were statistically significant differences among ESV, EF, Spl and EDMass (F=3.829, 6.596, 2.653, 6.596, P<0.05). There were statistically significant differences among ESV of group D and that of groups N, A, B and C (t=2.011, 2.244, 3.685 and 2.244, P<0.05). There was statistically significant difference among ESV of group B with that of group N (t=2.170, P<0.05). There were statistically significant differences among EF of group B with that of groups N, A and D (t=2.452, 3.514 and 2.452, P<0.05). There were statistically significant differences among EF of group D with that of groups N and C (t=2.849 and 3.486, P<0.05), There were statistically significant differences among SpI of group D with that of groups N, A, B and C (t=2.854, 2.941, 3.200 and 2.941, P<0.05). There were statistically significant differences among EDMass of group C with that of groups N and A (t=2.170 and 2.087, P<0.05). There were statistically significant differences among EDMass of group D with that of groups A, B and N (t=2.668, 2.081 and 3.762, P<0.05). There were statistically significant differences in GAS among groups A, B, C, D and group N (t=7.950, 7.361, 8.959 and 7.361, P<0.01), and the difference was more apparent with the increasing of left ventricular remodeling. There were statistically significant differences in the comparison of GAS in group D and groups A and B, respectively (t=3.332 and 2.102, P<0.05). There were statistically significant differences in the comparison of GAS in group A and group C (t=3.134, P<0.05). There were statistically significant differences in the comparison of group D and N in the segment of 1-17, respectively (t=2.967, 3.793, 4.896, 4.001, 2.375, 4.169, 4.077, 2.137, 4.652, 4.016, 5.230, 6.267, 5.735, 2.143, 2.353, 5.429 and 2.353, P<0.05). There were statistically significant differences in the comparison of groups A, B, C and group N, including basal anteroseptal, basal posteroseptal, basal anterolateral, mid anterolateral, apical anterior, apical lateral and apex (A-N: t=2.667, 3.084, 3.574, 4.771, 3.182, 4.806, 3.567, all P<0.05; B-N: t=2.702, 2.868, 2.179, 3.130, 3.302, 3.203, 3.093, all P<0.05; C-N: t=4.927, 5.600, 4.276, 6.577, 6.198, 5.190, 5.441, all P<0.05). There was no statistically significant difference in apical septal among the groups A, B, C and groups N (t=0.934, 1.562 and 0.934, P>0.05).

Conclusions

4D-area strain is a convenient and noninvasive method for evaluation of left ventricular systolic function in patients with different patterns of hypertension. Especially, it′s more sensitive in the early detection of left ventricular systolic function.

图2 向心性肥厚组(C组)高血压患者牛眼图。左侧为3个标准长轴切面左心室内、外膜网格图;中间为基底、中、心尖段3个短轴切面心内、外膜网格图,显示17个节段,与牛眼图相对应;右上图:黄线为各节段应变活动曲线记录,白点线为整体应变曲线;右下图:为17节段牛眼图,显示各节段面积应变锋值;G为整体应变锋值
表1 高血压各组常规参数与N组及组间比较(±s
表2 高血压患者A、B、C、D组与N组17节段面积应变参数测值(%,±s
组别 基底段 中间段
前壁 前间隔壁 后间隔壁 下壁 下侧壁 前侧壁 前壁 前间隔壁
A组 -20.18±6.35 -17.44±5.98b -17.58±5.47b -17.33±6.60 -13.82±6.00 -15.69±7.04b -22.20±7.40 -23.87±6.58
B组 -19.16±6.55 -16.60±5.06c -17.20±6.71c -19.04±7.57 -18.92±7.33 -17.27±7.64c -23.36±8.23 -25.04±8.04
C组 -16.04±7.56 -12.28±5.89d -12.60±5.11d -14.32±6.38 -13.28±6.00 -12.84±5013d -17.32±6.32 -17.76±5.22
D组 -17.6±8.12a -14.37±6.63a -12.40±5.24a -13.23±6.52a -11.97±5.01a -14.33±6.33a -18.43±7.28a -20.90±8.23a
N组 -23.43±9.77 -21.83±9.25 -22.03±6.41 -21.10±8.04 -17.35±7.03 -22.53±8.43 -26.45±10.11 -25.38±7.94
F 4.076 7.240 12.092 5.740 3.578 6.275 30.437 4.988
P <0.01 <0.01 <0.01 <0.01 <0.01 <0.01 <0.01 <0.01
组别 中间段 心尖段
后间隔壁 下壁 下侧壁 前侧壁 前壁 间隔壁 下壁 侧壁 心尖帽
A组 -24.24±5.78 -21.73±8.56 -18.84±8.01 -16.38±7.34b -16.71±7.30b -19.96±7.01 -20.07±8.40 -14.73±6.69b -11.42±5.02b
B组 -24.00±7.06 -25.32±7.42 -21.80±7.88 -19.52±8.23c -18.64±7.01c -23.76±8.94 -20.28±8.23 -16.76±6.89c -14.28±5.99c
C组 -16.76±5.23 -17.30±7.32 -12.28±5.66 -11.56±4.89d -14.04±6.01d -19.68±6.72 -17.12±7.34 -10.36±4.91d -10.92±4.73d
D组 -17.50±8.01a -18.90±8.81a -14.70±6.34a -12.77±5.87a -15.07±6.32a -20.43±8.29a -19.57±8.03a -13.47±6.04a -12.93±5.90a
N组 -26.65±5.66 -26.80±7.89 -25.38±8.55 -26.75±8.43 -26.35±8.46 -24.45±8.11 -24.20±8.26 -24.15±7.19 -21.05±8.09
F 13.527 20.895 9.986 15.540 12.728 2.633 5.468 11.302 6.889
P <0.01 <0.01 <0.01 <0.01 <0.01 <0.05 <0.01 <0.01 <0.01
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