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中华医学超声杂志(电子版) ›› 2017, Vol. 14 ›› Issue (10) : 734 -737. doi: 10.3877/cma.j.issn.1672-6448.2017.10.004

所属专题: 文献

浅表器官超声影像学

超声弹性成像对脉络膜黑色素瘤的诊断价值
陈伟1, 杨文利1,(), 李栋军1, 王子杨1, 赵琦1, 李逸丰1, 崔蕊1, 沈琳1   
  1. 1. 100730 首都医科大学附属北京同仁医院 北京同仁眼科中心 眼内肿瘤诊治研究北京市重点实验室 北京市眼科学与视觉科学重点实验室
  • 收稿日期:2017-07-27 出版日期:2017-10-01
  • 通信作者: 杨文利
  • 基金资助:
    北京市医院管理局"登峰"人才培养计划(DFL20150201); 眼内肿瘤诊治研究北京市重点实验室2015年度科技创新基地培育与发展专项项目(Z151100001615052); 国家自然科学基金(81570891); 北京市医院管理局临床医学发展专项经费资助(扬帆计划)(ZYLX201307); 北京市自然科学基金(7151003); 北京市卫生系统高层次卫生技术人才培养计划(2014-2-003)

Diagnostic value of ultrasonic elastosonography in choroidal melanoma

Wei Chen1, Wenli Yang1,(), Dongjun Li1, Ziyang Wang1, Qi Zhao1, Yifeng Li1, Rui Cui1, Lin Shen1   

  1. 1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China
  • Received:2017-07-27 Published:2017-10-01
  • Corresponding author: Wenli Yang
  • About author:
    Corresponding author: Yang Wenli, Email:
引用本文:

陈伟, 杨文利, 李栋军, 王子杨, 赵琦, 李逸丰, 崔蕊, 沈琳. 超声弹性成像对脉络膜黑色素瘤的诊断价值[J]. 中华医学超声杂志(电子版), 2017, 14(10): 734-737.

Wei Chen, Wenli Yang, Dongjun Li, Ziyang Wang, Qi Zhao, Yifeng Li, Rui Cui, Lin Shen. Diagnostic value of ultrasonic elastosonography in choroidal melanoma[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2017, 14(10): 734-737.

目的

通过对脉络膜黑色素瘤行超声弹性成像检查,测算肿瘤的应变率比值,分析脉络膜黑色素瘤的超声弹性成像特征,从而探讨超声弹性成像对脉络膜黑色素瘤的诊断价值。

方法

选取2016年6月至2017年6月于首都医科大学附属北京同仁医院眼科就诊的临床诊断为脉络膜黑色素瘤患者96例(97只眼),对照脉络膜血管瘤患者18例(18只眼),对2组患眼进行超声弹性成像检查,测算肿瘤组织与周围正常组织的应变率比值,对脉络膜黑色素瘤组与脉络膜血管瘤组的应变率比值行独立样本t检验,从而探讨超声弹性成像对脉络膜黑色素瘤的诊断价值。

结果

测得2组肿瘤的应变率比值分别为脉络膜黑色素瘤39.51±15.79,脉络膜血管瘤13.15±10.40;脉络膜黑色素瘤与脉络膜血管瘤的应变率比值比较,差异有统计学意义(t=6.802,P<0.001)。

结论

眼内恶性肿瘤脉络膜黑色素瘤的硬度(应变率比值)明显高于眼内良性肿瘤脉络膜血管瘤,超声弹性成像可作为辅助脉络膜黑色素瘤诊断及鉴别诊断的重要检查方法。

Objective

To explore the diagnostic value of ultrasonic elastography in choroidal melanoma.

Methods

A total of 96 cases (97 eyes) of choroidal melanoma were included in present study from June 2016 to June 2017 in Eye Center of Beijing Tongren Hospital, Capital Medical University. The control group consisted of 18 patients with choroidal hemangioma (18 eyes). All eyes were examined by color Doppler ultrasound and ultrasonic elastosonography. The strain ratio of the tumor and surrounding normal tissue was calculated for each case. By comparing the strain ratio between choroidal melanoma and choroidal hemangioma, the diagnostic value of ultrasound elastography in choroidal melanoma was investigated.

Results

The strain ratios of the two groups were 39.51±15.79 for choroidal melanoma and 13.15±10.40 for choroidal hemangioma. The independent sample t-test was performed between the two sets of data. The difference of the strain ratio between choroidal melanoma and choroidal hemangioma was statistically significant (t=6.802, P<0.001).

Conclusions

The stiffness of ocular malignant tumor (choroidal melanoma) is significantly higher than that in intraocular benign tumor (choroidal hemangioma). Ultrasonic elastography can be used as an important examination for the diagnosis and differential diagnosis of choroidal melanoma.

图3 脉络膜血管瘤弹性图像。右眼视盘鼻侧玻璃体内可见半球形实性病变,边界清晰,内回声为较均匀中强回声,瘤体蓝绿相间,以绿色为主,选取瘤体与眶内正常组织(绿色)测得应变率比值为4.01
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