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中华医学超声杂志(电子版) ›› 2022, Vol. 19 ›› Issue (10) : 1103 -1107. doi: 10.3877/cma.j.issn.1672-6448.2022.10.014

浅表器官超声影像学

乳腺纤维腺瘤的超声诊断及误诊分析
代妮娜1, 张文君1,()   
  1. 1. 442000 十堰,湖北医药学院附属太和医院超声医学科
  • 收稿日期:2021-02-23 出版日期:2022-10-01
  • 通信作者: 张文君

Ultrasonic diagnosis of breast fibroadenoma and analysis of causes of misdiagnosis

Nina Dai1, Wenjun Zhang1,()   

  1. 1. Department of Ultrasound, Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, Shiyan 442000, China
  • Received:2021-02-23 Published:2022-10-01
  • Corresponding author: Wenjun Zhang
引用本文:

代妮娜, 张文君. 乳腺纤维腺瘤的超声诊断及误诊分析[J/OL]. 中华医学超声杂志(电子版), 2022, 19(10): 1103-1107.

Nina Dai, Wenjun Zhang. Ultrasonic diagnosis of breast fibroadenoma and analysis of causes of misdiagnosis[J/OL]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2022, 19(10): 1103-1107.

目的

探讨乳腺纤维腺瘤的典型与非典型超声特征及诊断结果,对超声误诊率进行分析。

方法

回顾性分析2015年至2020年在湖北医药学院附属太和医院经手术病理证实的乳腺纤维腺瘤患者392例(401个肿块)的典型与非典型超声声像图特征及诊断结果。以病理结果为标准,比较不同年龄、不同直径大小、不同非典型特征以及不同病理类型的肿块超声误诊率的差异。

结果

401个肿块中,超声观察到非典型特征的123个,其中正确诊断40个,误诊83个;超声表现为典型特征的278个,均正确诊断。直径<1 cm病灶的误诊率(31.5%)和直径>3 cm病灶的误诊率(34.9%)显著高于直径1~3 cm病灶的误诊率(16.8%),差异均有统计学意义(P均<0.017)。非典型特征≥2种的肿块其超声误诊率(83.5%)显著高于无非典型特征(0)及有1种非典型特征肿块的误诊率(38.6%),差异均有统计学意义(P均<0.001)。复杂型纤维腺瘤87个,非复杂型纤维腺瘤314个,复杂型纤维腺瘤的误诊率(71.2%)显著高于非复杂型纤维腺瘤(6.7%),差异有统计学意义(χ2=1.731,P<0.001)。复杂型纤维腺瘤以非典型特征≥2种的肿块居多(79.3%),与非复杂型纤维腺瘤的非典型特征比较,差异有统计学意义(χ2=2.870,P<0.001)。

结论

纤维腺瘤的超声误诊率与非典型特征的多少、肿块直径的大小有关,复杂型纤维腺瘤超声声像图更易表现出非典型特征而被误诊。

Objective

To investigate the typical and atypical ultrasound features of breast fibroadenoma, and analyze the causes of ultrasound misdiagnosis.

Methods

A retrospective analysis was performed on 392 cases (401 masses) of breast fibroadenoma confirmed by surgery and pathology at Taihe Hospital Affiliated to Hubei Medical College from 2015 to 2020. Based on the pathological results, we compared the ultrasonic misdiagnosis rate by patient ages, tumor diameter, atypical feature, and pathological type.

Results

Among the 401 masses included, 123 atypical features were observed by ultrasonography, of which 40 were correctly diagnosed and 83 were misdiagnosed; 278 cases with typical ultrasonic features were diagnosed correctly. The misdiagnosis rate of lesions with a diameter less than 1 cm (31.5%) and larger than 3 cm (34.9%) was significantly higher than that of lesions with a diameter of 1~3 cm (16.8%; P<0.017). The ultrasonic misdiagnosis rate of tumors with ≥2 atypical features (83.5%) was significantly higher than that of tumors without atypical features (0) and with 1 atypical feature (38.6%; P<0.001). There were 87 complex fibroadenomas and 314 noncomplex fibroadenomas. The misdiagnosis rate of complex fibroadenomas (71.2%) was significantly higher than that of noncomplex fibroadenomas (6.7%; χ2=1.731, P<0.001). The number of atypical features of complex fibroadenoma was often more than or equal to 2, and the percentage of complex fibroadenomas with more than or equal to 2 atypical features was significantly higher than that of noncomplex fibroadenomas (χ2=2.870, P<0.001).

Conclusion

The ultrasonic misdiagnosis rate of fibroadenoma is related to the number of atypical features and the size of the mass. Complex fibroadenoma are more likely to show atypical ultrasonic features and be misdiagnosed.

表1 不同年龄患者的肿块超声诊断误诊率比较
表2 不同直径大小的肿块超声诊断误诊率比较
表3 不同非典型特征的肿块超声诊断误诊率比较
表4 不同类型纤维腺瘤超声非典型特征比较[例(%)]
图1 乳腺纤维腺瘤非典型超声表现。图a为二维超声图像示病灶形态不规则,边缘成角,内见多个点状钙化,超声误诊为乳腺癌,病理诊断为非复杂型纤维腺瘤
图2 乳腺纤维腺瘤非典型超声表现。二维超声图像示病灶直径<1 cm,纵横比=1,内见多个点状钙化,超声诊断未定性,病理诊断为非复杂型纤维腺瘤
图3 乳腺纤维腺瘤非典型超声表现。二维超声图像示病灶形态尚规则,内见小无回声区及多个点状强回声,超声诊断为纤维腺瘤,病理诊断为复杂型纤维腺瘤,与超声诊断相符合
图4 乳腺纤维腺瘤非典型超声表现。二维超声图像示病灶形态欠规则,内部回声区不均匀,周边见无回声区呈囊实混合性,超声误诊为乳腺导管内乳头状瘤,病理诊断为复杂型纤维腺瘤
图5 乳腺纤维腺瘤非典型超声表现。二维超声图像示病灶边界欠清,内见多个钙化灶,超声误诊为乳腺癌,病理诊断为非复杂型纤维腺瘤
图6 乳腺纤维腺瘤非典型超声表现。二维超声图像示病灶直径>3 cm,形态不规则,呈分叶状,超声误诊为乳腺叶状肿瘤,病理诊断为非复杂型纤维腺瘤
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