To evaluate the fallopian tube patency with transvaginal real-time three-dimensional hysterosalpingo-contrast sonography (3D-HyCoSy) in diagnosis of infertility.

Taking laparoscopy and dye test as the reference standard, a total of 126 infertile women underwent both transvaginal real-time 3D-HyCoSy with SonoVue and laparoscopy. Bilateral fallopian tubes were dynamic observed.

Transvaginal real-time 3D-HyCoSy showed that in clinical suspected infertility patients, 125 fallopian tubes were patent, 81 fallopian tubes were narrow and circuitous, and 37 fallopian tubes were obstructed. Among all the patients, 60 cases (115 fallopian tubes) underwent laparoscopy with chromopertubation. The results showed that 10 fallopian tubes were patent, 73 fallopian tubes were narrow and circuitous, and 32 fallopian tubes were obstructed. Taking laparoscopy and dye test as the reference standard, 107 fallopian tubes of the 60 cases were diagnosed correctly, and the coincidence rate of 3D-HyCoSy and laparoscopy and dye test was 93.0% (107/115). Taking laparoscopy and dye test as the gold standard, the accuracy of transvaginal real-time 3D-HyCoSy in diagnosis of fallopian tubes patency or obstruction was 93.0% (107/115), the sensitivity was 94.3% (99/105), the specificity was 80.0% (8/10).

Tansvaginal real-time 3D-HyCoSy can provide dynamic, real-time and three-dimensional display of the fallopian tubes. It can get more accurate diagnostic information, so it′s an important method. 3D-HyCoSy is a safe and non-invasive method, so it plays an important clinical role in the screening, diagnosis and treatment of gynecological diseases.