The research on clinical and ultrasonographic features of ovarian clear cell carcinoma

doi:10.3877/cma.j.issn.1672-6448.2018.08.010

Abstract

Abstract:

Objective

To investigate the ultrasound characteristics of ovarian clear cell carcinoma (OCCC) and provide basis for early diagnosis of OCCC.

Methods

Retrospective analysis was performed on 45 patients with OCCC, who were pathologically diagnosed and treated in Beijing Friendship Hospital, Capital Medical University from January 2005 to May 2017.

Results

In forty-five cases of OCCC, forty-six lesions were found (forty-four cases of unilateral ovarian lesions, one case of bilateral ovarian lesion). Among forty-six lesions, thirty-two (69.6%) were regular in shape, fourteen (30.4%) were irregular. Among forty-six lesions, forty (87.0%) had clear margin, six (13.0%) had blurry margin. The maximum diameter of lesion was 4.8-17.6 cm with mean value of 10.2±3.4 cm. Fifteen lesions (32.6%) were predominantly solid, twelve lesions (26.1%) were cystic, and nineteen lesions (41.3%) were mixed. The color Doppler examination showed that twenty-eight (69.9%) lesions had abundant blood flow, while eighteen (39.1%) lesions had little blood flow. Ascites was found in six (13.3%) cases.

Conclusions

OCCC usually appears as a large unilateral mass with mixed component, clear margin and abundant blood flow.Ultrasound examination can play an important role in the early diagnosis of OCCC, and provide valuable information for surgical treatment.

Key words: Ultrasonography, Ovarian tumors, Ovarinan clear cell carcinoma

Wei Liu, Changhong Li, Yingqi Lin, Qinying Zhou, Linxue Qian. The research on clinical and ultrasonographic features of ovarian clear cell carcinoma[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2018, 15(08): 616-619.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2018.08.010

https://chaosheng.cma-cmc.com.cn/EN/Y2018/V15/I08/616

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References 15

1	Kennedy AW, Biscotti CV, Hart WR, et al. Ovarian clear cell adenocarcinoma [J]. Gynecol Oncol, 1989, 32(3):342-349.
2	佟晓晶，王晓彬，李联昆. 原发性卵巢透明细胞癌70例预后因素分析 [J]. 中国实用妇科与产科杂志, 2015, 31(2):153-155.
3	Matsuura Y, Robertson G, Marsden DE, et al. Thromboembolic complications in patients with clear cell carcinoma of the ovary [J]. Gynecol Oncol, 2007, 104(2):406-410.
4	吴小肄，徐洁，徐丛剑, 等. 卵巢透明细胞癌的临床特点及预后分析 [J]. 中国临床医学, 2011, 18(5):693-695.
5	马绍康，张宏图，吴令英, 等. 88例卵巢透明细胞癌临床及预后分析 [J]. 中华肿瘤杂志, 2007, 29(10):784-788.
6	朱丽莎，刘玲，邓燕杰. 卵巢透明细胞癌合并卵巢子宫内膜异位症的临床病理学分析 [J/CD]. 中华妇幼临床医学杂志(电子版), 2015, 11(1):68-72.
7	Heaps JM, Nieberg RK, Berek JS. Malignant neoplasms arising in endometriosis [J]. Obstet Gynecol, 1990, 75(6):1023-1028.
8	Pearce CL, Templeman C, Rossing MA, et al. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies [J]. Lancet Oncol, 2012, 13(4):385-394.
9	杨莹超，王雪梅，李小平, 等. 60例卵巢透明细胞癌临床分析 [J]. 中国妇产科临床杂志, 2016, 17(6):516-518.
10	Sampson J. Endometrial carcinoma of the ovary arising in endometrial tissue in that organ [J]. Arch Surg, 1925, 10:1-2.
11	Somigliana E, Vigano′ P, Parazzini F, et al. Association between endometriosis and cancer: a comprehensive review and a critical analysis of clinical and epidemiological evidence [J]. Gynecol Oncol, 2006, 101(2):331-341.
12	Penson RT, Dizon DS, Birrer MJ. Clear cell cancer of the ovary [J]. Curr Opin Oncol, 2013, 25(5):553-557.
13	Scarfone G, Bergamini A, Noli S, et al. Characteristics of clear cell ovarian cancer arising from endometriosis: a two center cohort study [J]. Gynecol Oncol, 2014, 133(3):480-484.
14	刘国艳，袁碧波，糜若然. 卵巢透明细胞癌诊治进展 [J]. 国际妇产科学杂志, 2012, 39(4):364-367; 372.
15	鲁红. 妇科超声诊断与鉴别诊断 [M]. 北京: 人民军医出版社, 2012: 288-289.

超声分型	个数	大小（?±s?）	边界		形态		血供
超声分型	个数	大小（?±s?）	清晰	不清晰	规则	不规则	丰富	不丰富
实性为主	15	9.6±3.3	12	3	8	7	11	4
囊性为主	12	10.8±4.2	11	1	10	2	4	8
囊实混合性	19	10.4±3.0	17	2	14	5	13	6

超声分型	个数	大小（?±s?）	边界		形态		血供
超声分型	个数	大小（?±s?）	清晰	不清晰	规则	不规则	丰富	不丰富
实性为主	15	9.6±3.3	12	3	8	7	11	4
囊性为主	12	10.8±4.2	11	1	10	2	4	8
囊实混合性	19	10.4±3.0	17	2	14	5	13	6

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