The ultrasound diagnosis of thyroid carcinoma in children and teenagers

doi:10.3877/cma.j.issn.1672-6448.2019.03.009

Abstract

Abstract:

Objective

To analyze ultrasonographic features of thyroid carcinoma in childhood and adolescents.

Methods

In this study, the ultrasonographic features of 66 cases of children and adolescents who were diagnosed as thyroid carcinoma in the Department of Ultrasound of Jiang Su Province Hospital of Integrated Traditional Chinese and Western Medicine from January 2012 to May 2017 were retrospectively analyzed. All the thyroid nodules were confirmed by pathology.

Results

The results of preoperative ultrasound showed that in 66 cases of pediatric thyroid cancer, there were 56 cases of nodular type (55/66, 84.8%), 47 cases of microcalcification (47/56, 83.9%), 44 cases of irregular contour (44/56, 78.6%), 37 cases of unclear boundary (37/56, 66.1%), 14 cases of cervical lymph node metastasis (14/56, 25%). In 10 cases of diffuse type (15.2%, 10/66), there were 10 cases of microcalcification (10/10, 100%), 7 cases of hypoechoic cervical lymph node metastasis (7/10, 70%). Pathology confirmed 64 cases of papillary thyroid carcinoma (including 10 cases of diffuse sclerosing variant papillary carcinoma of thyroid) and 2 cases of follicular carcinoma.

Conclusion

Early diagnosis of ultrasound can provide valuable diagnostic information for the choice of surgical procedures and treatment for the patients.

Key words: Ultrasonography, Thyroid carcinoma, Chidren, Adolescents

Sujuan Li, Xuedong Deng, Xinping Wu. The ultrasound diagnosis of thyroid carcinoma in children and teenagers[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2019, 16(03): 202-206.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2019.03.009

https://chaosheng.cma-cmc.com.cn/EN/Y2019/V16/I03/202

Figures/Tables 5

References 21

1	周梁. 分化型甲状腺癌的诊断与治疗 [J]. 中华耳鼻咽喉头颈外科杂志, 2007, 42(12): 962-964.
2	Halac I, Zimmerman D. Thyroid nodules and cancers in children [J]. Endocrinol Metab Clin North Am, 2005, 34(3): 725-744.
3	Dinauer CA, Breuer C, Rivkees SA. Differentiated thyroid cancer in children: diagnosis and management [J]. Curr Opin Oncol, 2008, 20(1): 59-65.
4	Papendieck P, Gruñeiro-Papendieck L, Venara M, et al. Differentiated thyroid carcinoma: presentation and follow-up in children and adolescents [J]. J Pediatr Endocrinol Metab, 2011, 24(9-10): 743-748.
5	Gupta A, Ly S, Castroneves LA, et al. A standardized assessment of thyroid nodules in children confirms higher cancer prevalence than in adults [J]. J Clin Endocrinol Metab, 2013, 98(8): 3238-3245.
6	Baş VN, Aycan Z, Cetinkaya S, et al. Thyroid nodules in children and adolescents: a single institution′s experience [J]. J Pediatr Endocrinol Metab, 2012, 25(7-8): 633-638.
7	Hogan AR, Zhuge Y, Perez EA, et al. Pediatric thyroid carcinoma: incidence and outcomes in 1753 patients [J]. J Surg Res, 2009, 156(1): 167-172.
8	Adam MA, Pura J, Goffredo P, et al. Presence and Number of Lymph Node Metastases Are Associated With Compromised Survival for Patients Younger Than Age 45 Years With Papillary Thyroid Cancer [J]. J Clin Oncol, 2015, 33(21): 2370-2375.
9	Roh JL, Kim JM, Park CI. Central lymph node metastasis of unilateral papillary thyroid carcinoma: patterns and factors predictive of nodal metastasis, morbidity, and recurrence [J]. Ann Surg Oncol, 2011, 18(8): 2245-2250.
10	Yoon JH, Kim JY, Moon HJ, et al. Contribution of computed tomography to ultrasound in predicting lateral lymph node metastasis in patients with papillary thyroid carcinoma [J]. Ann Surg Oncol, 2011, 18(6): 1734-1741.
11	Kim DW, Choo HJ, Lee YJ, et al. Sonographic features of cervical lymph nodes after thyroidectomy for papillary thyroid carcinoma [J]. J Ultrasound Med, 2013, 32(7): 1173-1180.
12	Paulson LM, Shindo ML, Schuff KG. Role of chronic lymphocytic thyroiditis in central node metastasis of papillary thyroid carcinoma [J]. Otolaryngol Head Neck Surg, 2012, 147(3): 444-449.
13	Del Rio P, Cataldo S, Sommaruga L, et al. The association between papillary carcinoma and chronic lymphocytic thyroiditis: does it modify the prognosis of cancer? [J]. Minerva Endocrinol, 2008, 33(1): 1-5.
14	Spencer CA. Clinical review: Clinical utility of thyroglobulin antibody (TgAb) measurements for patients with differentiated thyroid cancers (DTC) [J]. J Clin Endocrinol Metab, 2011, 96(12): 3615-3627.
15	Hacıhamdioğlu B, Oçal G, Berberoğlu M, et al. The evaluation of thyroid carcinoma in childhood and concomitance of autoimmune thyroid disorders [J]. J Pediatr Endocrinol Metab, 2014, 27(9-10): 901-908.
16	鞠丽君, 刘浩, 刘冬. 儿童乳头状甲状腺癌高频超声声像图特征分析 [J/CD]. 中华临床医师杂志(电子版), 2012, 6(18): 153-155.
17	Samuel AM, Sharma SM. Differentiated thyroid carcinomas in children and adolescents [J]. Cancer, 1991, 67(8): 2186-2190.
18	Batawil N, Alkordy T. Ultrasonographic features associated with malignancy in cytologically indeterminate thyroid nodules [J]. Eur J Surg Oncol, 2014, 40(2): 182-186.
19	Kapila K, Pathan SK, George SS, et al. Fine needle aspiration cytology of the thyroid in children and adolescents: experience with 792 aspirates [J]. Acta Cytol, 2010, 54(4): 569-574.
20	朱蓓琳, 邬宏恂, 臧亚萍, 等. 甲状腺弥漫硬化型乳头状癌的超声特征及价值 [J]. 中国超声医学杂志, 2014, 30(10): 867-870．
21	Altıncık A, Demir K, Abacı A, et al. Fine-needle aspiration biopsy in the diagnosis and follow-up of thyroid nodules in childhood [J]. J Clin Res Pediatr Endocrinol, 2010, 2(2): 78-80.

超声分型	例数	病灶位置			大小		边界		回声
超声分型	例数	左	右	两叶	≥1 cm	<1 cm	清晰	不清晰	低	等	高
结节型	56	22	26	8	27	29	19	37	37	19	0
弥漫型	10	1	2	7	10	0	0	10	10	0	0
超声分型	例数	微钙化		毛刺样结构		纵横比		淋巴结转移
超声分型	例数	有	无	有	无	>1	<1	有	无
结节型	56	47	9	44	12	43	13	14	42
弥漫型	10	10	0	0	0	0	0	7	3

超声分型	例数	病灶位置			大小		边界		回声
超声分型	例数	左	右	两叶	≥1 cm	<1 cm	清晰	不清晰	低	等	高
结节型	56	22	26	8	27	29	19	37	37	19	0
弥漫型	10	1	2	7	10	0	0	10	10	0	0
超声分型	例数	微钙化		毛刺样结构		纵横比		淋巴结转移
超声分型	例数	有	无	有	无	>1	<1	有	无
结节型	56	47	9	44	12	43	13	14	42
弥漫型	10	10	0	0	0	0	0	7	3

超声分型	病理类型
超声分型	乳头状癌	滤泡癌	弥漫硬化型乳头状癌	髓样癌	未分化癌
结节型	54	2	0	0	0
弥漫型	0	0	10	0	0

超声分型	病理类型
超声分型	乳头状癌	滤泡癌	弥漫硬化型乳头状癌	髓样癌	未分化癌
结节型	54	2	0	0	0
弥漫型	0	0	10	0	0

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