Value of contrast-enhanced ultrasound in differential diagnosis of breast phyllodes tumor and fibroadenoma

doi:10.3877/cma.j.issn.1672-6448.2020.01.006

Abstract

Abstract:

Objective

To assess the value of contrast-enhanced ultrasound in the differential diagnosis of breast phyllodes tumor and fibroadenoma.

Methods

A retrospective analysis of contrast-enhanced ultrasound findings was performed on patients who were pathologically diagnosed with phyllodes tumor (23 cases) or fibroadenoma (57 cases). The differences between breast phyllodes tumors and fibroadenoma in contrast-enhanced ultrasound findings and pathological microvessel density were analyzed by the Chi-square test or t-test.

Results

There was no statistically significant difference (P>0.05) in boundary, but there were statistically significant differences in the sequence, degree, and evenness of contrast enhancement between breast phyllodes tumor and fibroadenoma (χ²=22.960, 24.419, 4.901, all P<0.05). The contrast-enhanced ultrasound findings of breast phyllodes tumor were characterized by a clear boundary and peripheral heterogeneous low enhancement. The contrast-enhanced ultrasound findings of fibroadenoma were characterized by a clear boundary and central homogeneous high enhancement.

Conclusion

Contrast-enhanced ultrasound has appreciated value in the differential diagnosis of breast phyllodes tumor and fibroadenoma, and can provide a reference for the selection of surgical methods.

Key words: Ultrasonography, Contrast agent, Breast, Phyllodes tumor, Fibroadenoma

Linlin Wang, Jianqiang Fang, Erqing Li. Value of contrast-enhanced ultrasound in differential diagnosis of breast phyllodes tumor and fibroadenoma[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2020, 17(01): 29-32.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2020.01.006

https://chaosheng.cma-cmc.com.cn/EN/Y2020/V17/I01/29

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References 17

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组别	例数	边界[例（%）]		增强顺序[例（%）]		增强均匀性[例（%）]		增强强度[例（%）]		MVD（条/200倍视野，±s）
组别	例数	清楚	不清楚	向心性	离心性	均匀	不均匀	高增强	低增强	MVD（条/200倍视野，±s）
叶状肿瘤	23	18（78.26）	5（21.76）	3（13.04）	20（86.96）	4（17.39）	19（82.61）	11（47.83）	12（52.17）	17.11±7.52
纤维腺瘤	57	49（85.96）	8（14.04）	41（71.93）	16（28.07）	44（77.19）	13（22.81）	42（73.68）	15（26.32）	23.15±5.85
统计值	?	χ²=0.261^b		χ²=22.960^a		χ²=24.419^a		χ²=4.901^a		t=2.655
P值	?	0.610		<0.001		<0.001		0.027		0.011

组别	例数	边界[例（%）]		增强顺序[例（%）]		增强均匀性[例（%）]		增强强度[例（%）]		MVD（条/200倍视野，±s）
组别	例数	清楚	不清楚	向心性	离心性	均匀	不均匀	高增强	低增强	MVD（条/200倍视野，±s）
叶状肿瘤	23	18（78.26）	5（21.76）	3（13.04）	20（86.96）	4（17.39）	19（82.61）	11（47.83）	12（52.17）	17.11±7.52
纤维腺瘤	57	49（85.96）	8（14.04）	41（71.93）	16（28.07）	44（77.19）	13（22.81）	42（73.68）	15（26.32）	23.15±5.85
统计值	?	χ²=0.261^b		χ²=22.960^a		χ²=24.419^a		χ²=4.901^a		t=2.655
P值	?	0.610		<0.001		<0.001		0.027		0.011

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