Comparison of SonoVue and Sonazoid in localization of sentinel lymph nodes in early breast cancer patients

doi:10.3877/cma.j.issn.1672-6448.2021.02.007

Abstract

Abstract:

Objective

To compare the application of SonoVue and Sonazoid in the localization of sentinel lymph nodes (SLN) in early breast cancer patients.

Methods

A total of 204 patients with T1-2 breast cancer diagnosed at Peking University Third Hospital from January 1, 2018 to January 30, 2020 were included. All patients underwent axillary lymph node dissection or sentinel lymph node biopsy to obtain the pathological results, and all patients underwent contrast-enhanced ultrasound examination before operation. According to the type of contrast agent used, the patients were divided into either a SonoVue group (135 cases, including 1 male case) or a Sonazoid group (69 cases). The number and time of enhancement of SLN in the two groups were observed, and the two contrast agents were then compared with methylene blue staining.

Results

Among the 135 patients in the SonoVue group, 210 SLNs were detected by CEUS and 297 by methylene blue staining, and the difference was statistically significant (t=6.964, P=0.000); among 69 patients in the Sonazoid group, 102 SLNs were detected by CEUS and 139 by methylene blue staining, and the difference was also statistically significant (t=3.763, P=0.000). Among the 135 patients in the SonoVue group, 1 failed in angiography localization, and 4 failed in methylene blue staining localization; all the 68 patients in the Sonazoid group all succeeded in localization, but 3 cases failed in methylene blue staining localization, with no significant difference (P=0.370, 0.244).The success rate of enhancement between in the SonoVue and Sonazoid groups was 99.3% vs 100%, and the difference was not statistically significant (P＞0.05).There was no SLN enhancement in the SonoVue group at 60 and 120 min after injection of the contrast medium. The blue stained lymph nodes in the Sonazoid group had continued enhancement in saline.

Conclusion

The diagnostic value of Sonazoid in sentinel lymph nodes in early breast cancer patients is not lower than that of SonoVue,and its ability of continuous enhancement of SLN is expected to be used for intraoperative confirmation of the accuracy and completeness of SLN removal.

Key words: Ultrasonography, Contrast medium, Sentinel lymph node, Breast carcionma

Yan Sun, Yutao Lei, Yunxia Hao, Shumin Wang, Shi Tan, Ligang Cui. Comparison of SonoVue and Sonazoid in localization of sentinel lymph nodes in early breast cancer patients[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2021, 18(02): 159-163.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2021.02.007

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Figures/Tables 2

References 14

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