Clinical efficacy of focused ultrasound ablation for uterine broad ligament leiomyoma

doi:10.3877/cma.j.issn.1672-6448.2021.12.014

Abstract

Abstract:

Objective

To evaluate the clinical efficacy of focused ultrasound ablation in patients with uterine broad ligament leiomyoma.

Methods

From April 2018 to August 2019, 48 patients with uterine broad ligament leiomyoma treated at Yiwu Central Hospital were included as the subjects. Among them, 24 patients were treated by uterine artery embolization and 24 patients by focused ultrasound ablation. The therapeutic effect, adverse reactions, tumor volume, time to postoperative symptom relief, and estrogen changes were recorded. The χ²-test was used to compare differences in the therapeutic effect and adverse reactions between the two groups, and the t-test was used to compare differences in tumor volume, time to postoperative symptom relief, and estrogen changes between the two groups.

Results

The total effective rate in the embolization and ablation groups was 91.67% and 95.83%, respectively; there was no significant difference between the two groups (P＞0.05). The incidence of adverse reactions also did not differ significantly between the embolization group and ablation group (29.17% vs 25.00%, P＞0.05). Before treatment, there was no significant difference in the volume of leiomyoma between the two groups (P＞0.05); at 6 months and 12 months after treatment, the volume of leiomyoma in the ablation group was significantly smaller than that in the embolization group [(22.45±6.78) cm³ vs (32.82±8.63) cm³, t=5.762, P=0.001; (3.25±1.34) cm³ vs (8.26±1.47) cm³, t=5.081, P=0.001]. The time to relief of compression symptom and dysmenorrhea symptom in the ablation group was significantly shorter than that in the embolization group [(6.42±1.34) d vs (8.92±1.65) d, t=5.762, P=0.001; (10.27±2.13) d vs (13.74±2.58) d, t=5.081, P=0.001]. There was no significant difference in follicle stimulating hormone and luteinizing hormone levels between the two groups before and after treatment (P＞0.05).

Conclusion

Focused ultrasound ablation is effective in the treatment of uterine broad ligament leiomyoma, which is comparable to that of uterine artery embolization. Focused ultrasound ablation can obviously reduce the volume of leiomyoma and shorten the time to symptom relief, which is worthy of clinical application and popularization.

Key words: Focused ultrasound ablation, Uterine broad ligament leiomyoma, Uterine artery embolization

Ping Wu, Yan Chen, Fenghua Chen, Lijing Zhang. Clinical efficacy of focused ultrasound ablation for uterine broad ligament leiomyoma[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2021, 18(12): 1203-1207.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2021.12.014

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Figures/Tables 7

References 21

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组别	例数	显效（例）	有效（例）	无效（例）	总有效率［例（%）］
栓塞组	24	13	9	2	22（91.67）
消融组	24	12	11	1	23（95.83）
χ²值					0.356
P值					0.551

组别	例数	显效（例）	有效（例）	无效（例）	总有效率［例（%）］
栓塞组	24	13	9	2	22（91.67）
消融组	24	12	11	1	23（95.83）
χ²值					0.356
P值					0.551

组别	例数	下腹疼痛（例）	盆腔疼痛（例）	皮肤灼痛（例）	骶尾部疼痛（例）	发生率［例（%）］
栓塞组	24	2	4	0	1	7（29.17）
消融组	24	3	1	1	1	6（25.00）
χ²值						0.105
P值						0.745

组别	例数	下腹疼痛（例）	盆腔疼痛（例）	皮肤灼痛（例）	骶尾部疼痛（例）	发生率［例（%）］
栓塞组	24	2	4	0	1	7（29.17）
消融组	24	3	1	1	1	6（25.00）
χ²值						0.105
P值						0.745

组别	例数	治疗前	治疗后6个月	治疗后12个月
栓塞组	24	54.82±12.64	32.82±8.63	8.26±1.47
消融组	24	54.76±12.58	22.45±6.78	3.25±1.34
t值		0.016	4.630	12.339
P值		0.987	0.001	0.001

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