Doppler blood flow parameters of uterine arteries in women in first trimester of pregnancy in Tibet Plateau

doi:10.3877/cma.j.issn.1672-6448.2022.08.013

Abstract

Abstract:

Objective

To compare the characteristics of uterine artery blood flow spectrum between early pregnant women at different altitudes.

Methods

A total of 144 pregnant women at different altitudes who received routine prenatal examination at the People's Hospital of Tibet Autonomous Region and Peking Union Medical College Hospital from June 2019 to January 2020 were prospectively included. Uterine artery Doppler spectrum was measured at 11⁺⁰~13⁺⁶ weeks of pregnancy. Paired t-test was used to compare the spectrum of bilateral uterine arteries. Independent sample t-test was used to compare the parameters of the uterine artery in pregnant women at difference altitudes, and pregnant women of different ethnic groups in high altitudes.

Results

There was no significant difference in Doppler parameters between the left and right uterine arteries in the same pregnant woman (P＞0.05). There was no significant difference in uterine artery pulsatility index (PI) between 43 pregnant women at a high altitude and 101 pregnant women at a low altitude (1.892±0.495 and 1.824±0.404, respectively, P＞0.05). In the high altitude area, the uterine artery PI of 28 Tibetan pregnant women (2.016±0.521) was higher than that of 15 Han pregnant women (1.661±0.351), the difference was statistically significant (t=-2.366, P=0.023).

Conclusion

There is no significant difference in the spectral characteristics of uterine artery blood flow in pregnant women at different altitudes, but the average PI of bilateral uterine arteries in Tibetan pregnant women at a high altitude is higher. The influencing factors of uterine artery blood flow spectrum characteristics need to be further studied.

Key words: Tibet autonomous region, High altitude, First trimester, Uterine artery, Ultrasonography, Doppler

Lin Gao, Yixiu Zhang, Xiao Yang, Sirui Liu, Yunshu Ouyang, Xining Wu, Zihan Niu, Meng Yang, Hua Meng. Doppler blood flow parameters of uterine arteries in women in first trimester of pregnancy in Tibet Plateau[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2022, 19(08): 801-806.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2022.08.013

https://chaosheng.cma-cmc.com.cn/EN/Y2022/V19/I08/801

Figures/Tables 6

组别	例数	汉族/藏族（例）	年龄（岁， $x ¯$ ±s）	体质量指数（kg/m²， $x ¯$ ±s）	孕周（周， $x ¯$ ±s）	胎儿头臀长（cm， $x ¯$ ±s）
高海拔组	43	15/28	29.33±3.13	21.64±2.02	12.55±0.52	6.18±0.77
低海拔组	101	101/0	32.11±3.85	21.89±1.97	12.67±0.51	6.36±0.78
统计值		χ²=81.642	t=4.188	t=0.981	t=1.304	t=1.275
P值		＜0.001	＜0.001	0.334	0.194	0.205

组别	例数	汉族/藏族（例）	年龄（岁， $x ¯$ ±s）	体质量指数（kg/m²， $x ¯$ ±s）	孕周（周， $x ¯$ ±s）	胎儿头臀长（cm， $x ¯$ ±s）
高海拔组	43	15/28	29.33±3.13	21.64±2.02	12.55±0.52	6.18±0.77
低海拔组	101	101/0	32.11±3.85	21.89±1.97	12.67±0.51	6.36±0.78
统计值		χ²=81.642	t=4.188	t=0.981	t=1.304	t=1.275
P值		＜0.001	＜0.001	0.334	0.194	0.205

参数	例数	PSV（cm/s）	EDV（cm/s）	TAM（cm/s）	S/D	PI	RI
右侧	144	87.81±22.37	20.94±9.79	38.78±12.67	4.88±2.65	1.822±0.496	0.764±0.084
左侧	144	92.54±26.63	21.91±10.90	40.87±15.65	5.04±2.28	1.869±0.559	0.769±0.079
t值		-1.821	-0.927	-1.432	-0.592	-0.929	-0.700
P值		0.071	0.356	0.154	0.555	0.355	0.485

组别	例数	右侧
组别	例数	PI		RI		PSV（cm/s）		EDV（cm/s）		TAM（cm/s）		S/D
高海拔组	43	1.876±0.542		0.764±0.091		86.96±21.87		20.52±9.41		37.09±10.97		4.56±1.38
低海拔组	101	1.800±0.476		0.764±0.082		88.17±22.67		21.12±9.98		34.49±12.32		5.01±3.03
t值		0.841		0.000		-0.296		-0.338		-1.040		-0.940
P值		0.402		1.000		0.768		0.736		0.300		0.349
组别	例数	左侧											双侧平均PI
组别	例数	PI	RI		PSV（cm/s）		EDV（cm/s）		TAM（cm/s）		S/D		双侧平均PI
高海拔组	43	1.912±0.686	0.765±0.092		92.60±28.88		22.53±12.71		40.67±17.23		5.33±3.00		1.892±0.495
低海拔组	101	1.851±0.499	0.771±0.073		92.51±25.77		21.64±10.09		40.95±15.02		4.92±1.88		1.824±0.404
t值		0.527	-0.374		0.019		0.447		-0.100		0.822		0.867
P值		0.600	0.710		0.985		0.655		0.921		0.414		0.387

组别	例数	妊娠11⁺⁰~11⁺⁶周
组别	例数	右侧PI	右侧RI	右侧S/D	左侧PI	左侧RI	左侧S/D	双侧平均PI
高海拔组	7	2.226±0.748	0.807±0.123	4.97±1.63	1.911±0.716	0.759±0.112	4.91±2.00	2.067±0.543
低海拔组	7	2.006±0.422	0.806±0.062	5.55±1.64	1.736±0.205	0.763±0.024	4.27±0.42	1.871±0.262
t值		-0.678	-0.027	0.638	-0.624	0.099	-0.836	-0.859
P值		0.511	0.979	0.536	0.552	0.924	0.433	0.407
组别	例数	妊娠12⁺⁰~12⁺⁶周
组别	例数	右侧PI	右侧RI	右侧S/D	左侧PI	左侧RI	左侧S/D	双侧平均PI
高海拔组	23	1.865±0.458	0.765±0.077	4.61±1.27	2.099±0.848	0.787±0.092	6.16±3.61	1.980±0.523
低海拔组	65	1.805±0.465	0.766±0.080	5.16±3.54	1.900±0.498	0.778±0.075	5.09±1.90	1.850±0.401
t值		-0.534	0.033	0.725	-1.192	-0.493	-1.361	-1.227
P值		0.595	0.974	0.470	0.243	0.623	0.185	0.223
组别	例数	妊娠13⁺⁰~13⁺⁶周
组别	例数	右侧PI	右侧RI	右侧S/D	左侧PI	左侧RI	左侧S/D	双侧平均PI
高海拔组	13	1.705±0.510	0.739±0.092	4.27±1.50	1.582±0.426	0.729±0.072	4.08±1.57	1.643±0.330
低海拔组	29	1.737±0.511	0.750±0.897	4.56±1.79	1.772±0.545	0.758±0.075	4.71±2.04	1.753±0.439
t值		-0.187	-0.371	-0.516	-1.109	-1.151	-0.988	-0.808
P值		0.853	0.713	0.609	0.274	0.256	0.329	0.424

民族	例数	年龄（岁）	体质量指数（kg/m²）	孕周（周）	胎儿头臀长（cm）	右侧子宫动脉			左侧子宫动脉			双侧子宫动脉平均PI
民族	例数	年龄（岁）	体质量指数（kg/m²）	孕周（周）	胎儿头臀长（cm）	PI	RI	S/D	PI	RI	S/D	双侧子宫动脉平均PI
汉族	15	28.33±2.06	21.06±1.57	12.37±0.46	5.91±0.68	1.695±0.419	0.735±0.085	4.10±1.17	1.628±0.423	0.729±0.077	4.01±1.19	1.661±0.351
藏族	28	29.86±3.49	21.95±2.19	12.65±0.53	6.32±0.79	1.972±0.581	0.780±0.091	4.81±1.44	2.064±0.756	0.784±0.094	6.03±3.43	2.016±0.521
t值		-1.798	-1.394	-1.716	-1.704	-1.628	-1.580	-1.642	-2.426	-1.937	-2.835	-2.366
P值		0.080	0.171	0.094	0.096	0.111	0.122	0.108	0.020	0.060	0.007	0.023

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