To assess the application value of left ventricular opacification (LVO) in acute myocardial infarction (AMI) with ventricular septal perforation (VSR).

From October 2020 to January 2022, 10 patients with AMI combined with VSR who were admitted to Wuhan Asia Cardiology Hospital, underwent bedside transthoracic echocardiography (TTE) and LVO examinations, and then underwent surgery were retrospectively selected as the study subjects. The type of VSR and the size of defect were analyzed, and the consistency of VSR measured by TTE and LVO was also analyzed.

Among the 10 VSR patients included, 9 (9/10) had left ventricular apex perforation, 9 (9/10) had single hole perforation of the interventricular septum, and all the 10 had simple type VSR. The coincidence rate between LVO and surgical results was 100% (10/10). The values of VSR measured by TTE, LVO, and surgery were (1.42±0.44), (1.50±0.40), and (1.51±0.41) cm, respectively, with no statistical significance among them (F=0.246, P=0.783). LVO had a strong consistency with surgery for size measurement of interventricular septal perforation (interclass correlation coefficient [ICC]=0.984 [0.936, 0.996], P<0.001), better than that of TTE (ICC=0.546 [-0.131, 0.876], P=0.051).

LVO can provide an important clinical basis for the treatment of AMI combined with VSR, and it can be an important supplementary examination method for TTE.