切换至 "中华医学电子期刊资源库"
高级检索
中华医学超声杂志（电子版）

中华医学超声杂志（电子版） ›› 2018, Vol. 15 ›› Issue (10) : 763 -766. doi: 10.3877/cma.j.issn.1672-6448.2018.10.007

所属专题： 文献；

腹部超声影像学

超声诊断弥漫性胰腺脂肪浸润的临床意义
于梦霞1, 於晓平2,†(), 孙红光1, 刘歆农3, 周娱3, 路国涛4   
  1. 1. 225012　扬州大学附属医院超声科
    2. 225012　扬州大学附属医院超声科；225012　扬州大学附属医院健康促进中心
    3. 225012　扬州大学附属医院健康促进中心
    4. 225012　扬州大学附属医院消化内科
  • 收稿日期:2017-07-08 出版日期:2018-10-01
  • 通信作者: 於晓平

Ultrasound diagnosis of diffuse pancreatic fatty infiltration and its relationship with blood lipids and blood glucose

Mengxia Yu1, Xiaoping Yu2,†(), Hongguang Sun1, Xinnong Liu3, Yu Zhou3, Guotao Lu4   

  1. 1. Department of Ultrasound, the Affiliated Hospital of Yangzhou University, Yangzhou 225012, China
    2. Department of Ultrasound, the Affiliated Hospital of Yangzhou University, Yangzhou 225012, China; Department of Health Promotion Centre, the Affiliated Hospital of Yangzhou University, Yangzhou 225012, China
    3. Department of Health Promotion Centre, the Affiliated Hospital of Yangzhou University, Yangzhou 225012, China
    4. Department of Gastroenterology, the Affiliated Hospital of Yangzhou University, Yangzhou 225012, China
  • Received:2017-07-08 Published:2018-10-01
  • Corresponding author: Xiaoping Yu
  • About author:
    Corresponding author: Yu Xiaping, Email:
全文 ( ) 下载PDF ( ) 导出引用
引用本文：

于梦霞, 於晓平, 孙红光, 刘歆农, 周娱, 路国涛. 超声诊断弥漫性胰腺脂肪浸润的临床意义[J]. 中华医学超声杂志（电子版）, 2018, 15(10): 763-766.

Mengxia Yu, Xiaoping Yu, Hongguang Sun, Xinnong Liu, Yu Zhou, Guotao Lu. Ultrasound diagnosis of diffuse pancreatic fatty infiltration and its relationship with blood lipids and blood glucose[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2018, 15(10): 763-766.

目的

探讨超声诊断弥漫性胰腺脂肪浸润的临床意义，分析弥漫性脂肪浸润与血脂、血糖浓度的关系。

方法

选取2016年6月~11月在扬州大学附属医院进行健康体检的64 155位受检者，超声诊断为弥漫性胰腺脂肪浸润的共1030例，随机选取同期无胰腺脂肪浸润的4229例受检者作为无胰腺脂肪浸润组，整理所选受检者的体检报告资料，通过χ2检验分析弥漫性胰腺脂肪浸润组与无胰腺脂肪浸润组间高血脂、高血糖发生率的差异，并采用独立样本t检验探讨弥漫性胰腺脂肪浸润与血脂、血糖浓度的关系。

结果

弥漫性胰腺脂肪浸润组空腹高血糖、高胆固醇、高甘油三酯的发生率分别为23.7%、14.1%及62.1%，无胰腺脂肪浸润组空腹高血糖、高胆固醇、高甘油三酯的发生率分别为11.1%、10.2%及34.5%，弥漫性胰腺脂肪浸润组空腹高血糖、高胆固醇、高甘油三酯的发生率显著高于无胰腺脂肪浸润组，差异均有统计学意义（χ2=112.74、13.00、259.36，P均<0.001）。弥漫性胰腺脂肪浸润组空腹血糖、胆固醇、甘油三酯的平均浓度分别为（5.86±1.91）mmol/L、（4.72±0.94）mmol/L及（2.45±2.03）mmol/L；无胰腺脂肪浸润组空腹血糖、胆固醇、甘油三酯的平均浓度分别为（5.30±1.31）mmol/L、（4.54±0.90）mmol/L及（1.74±1.80）mmol/L，弥漫性胰腺脂肪浸润组空腹血糖、胆固醇及甘油三酯浓度显著高于无胰腺脂肪浸润组，差异均有统计学意义（t=11.12、5.48、11.74，P均<0.001）。

结论

超声诊断弥漫性胰腺脂肪浸润对于提示无症状的高血脂、高血糖有重要的临床价值，可为临床早期进行干预治疗提供依据。

关键词: 胰腺, 脂肪浸润, 超声检查, 血脂, 血糖
Objective

To investigate the relationship between diffuse pancreatic fatty infiltration with blood lipids and blood glucose.

Methods

From June 2016 to November 2016, 64,155 subjects underwent physical examination in the affiliated hospital of Yangzhou University. There were 1030 cases of diffuse pancreatic fatty infiltration diagnosed by ultrasound. 4229 cases without pancreatic adipose infiltrate at the same time were randomly selected as a non-invasion group. The physical examination report data of the selected subjects were analyzed, and the differences in the incidence of hyperlipidemia and hyperglycemia between the diffuse pancreatic fat infiltration group and the non-pancreatic fat infiltration group were compared by χ2 test. Independent sample t test was used to explore the relationship between diffuse pancreatic fat infiltration and blood lipids and blood glucose.

Results

The incidence of fasting hyperglycemia, high cholesterol and high triglycerides was 23.7%, 14.1%, and 62.1% in diffuse pancreatic fat infiltration group, respectively. The incidence of fasting hyperglycemia, high cholesterol and high triglycerides in non-pancreatic fat infiltration group was 11.1%, 10.2%, and 34.5%, respectively. The incidence of fasting hyperglycemia, high cholesterol and high triglycerides in the diffuse pancreatic fat infiltration group was significantly higher than that in the non-pancreatic fat infiltration group (The value of χ2 were 112.74, 13.00 and 259.36, respectively, P<0.001). The average concentrations of fasting plasma glucose, cholesterol, and triglycerides in the diffuse pancreatic fat infiltration group were (5.86±1.91) mmol/L, (4.72±0.94) mmol/L and (2.45±2.03) mmol/L, respectively. The average concentrations of blood glucose, cholesterol and triglycerides in non-pancreatic fat infiltration group were (5.30±1.31) mmol/L, (4.54±0.90) mmol/L and (1.74±1.80) mmol/L, respectively. The average concentrations of fasting blood glucose, high cholesterol and high triglycerides in diffuse fatty pancreatic infiltration were significantly higher than those in the non-pancreatic fat infiltration group (P<0.001).

Conclusions

Diffuse pancreatic fat infiltration is significantly associated with fasting blood glucose, cholesterol and triglyceride concentrations. Ultrasound diagnosis of diffuse pancreatic fat infiltration has important clinical value for asymptomatic hyperlipidemia and hyperglycemia, and can be used for early clinical intervention and treatment.

Key words: the pancreas, Fatty infiltration, Ultrasound, Blood lipid, Blood glucose
图2 患者，女性，36岁，弥漫性胰腺脂肪浸润超声图像。胰腺形态饱满，胰腺回声强于肠系膜上动脉周围脂肪组织
表1 超声诊断弥漫性胰腺脂肪浸润组与无胰腺脂肪浸润组资料对比分析（例）
组别 例数 空腹血糖 胆固醇 甘油三酯
>6.11 mmol/L ≤6.11 mmol/L >5.69 mmol/L ≤5.69 mmol/L >1.70 mmol/L ≤1.70 mmol/L
弥漫性胰腺脂肪浸润组 1030 244 786 145 885 640 390
无胰腺脂肪浸润组 4229 468 3761 430 3799 1468 2761
χ2值 ? 112.74 13.00 259.36
P值 ? <0.001 <0.001 <0.001
表2 超声诊断弥漫性胰腺脂肪浸润组与无胰腺脂肪浸润组资料对比分析（mmol/L，±s）
分组 例数 空腹血糖 胆固醇 甘油三酯
弥漫性胰腺脂肪浸润组 1030 5.86±1.91 4.72±0.94 2.50±2.03
无胰腺脂肪浸润组 4229 5.30±1.31 4.54±0.90 1.74±1.80
t值 ? 11.12 5.48 11.74
P值 ? <0.001 <0.001 <0.001
1
周永昌，郭万学. 超声医学 [M]. 3版, 北京: 科学技术文献出版社, 1998: 897.
2
周永昌，郭万学. 超声医学 [M]. 5版, 北京: 科学技术文献出版社, 2007: 721.
3
Smereczynski A, Kolaczyk K. Is a fatty pancreas a banal lesion? [J] J Ultrason, 2016, 16(66): 273-280.
4
Jacobs JE, Coleman BG, Arger PH, et al. Pancreatic sparing of focal fatty infiltration [J] Radiology, 1994, 190(2): 437-439.
5
Yamazaki H, Tsuboya T, Katanuma A, et al. Lack of Independent Association Between Fatty Pancreas and Incidence of Type 2 Diabetes: 5-Year Japanese Cohort Study [J] Diabetes Care, 2016, 39(10): 1677-1683.
6
Glaser J, Stienecker K. Pancreas and aging: a study using ultrasonography [J]. Gerontology, 2000, 46(2): 93-96.
7
李北平，蒋宇，苏烈. 湖北地区老年人胰腺超声测值 [J] 中国医学影像技术, 2000, 16(6): 464-465.
8
Geach T. Pancreas: Fatty pancreas linked to increased BMI and insulin resistance in children [J]. Nat Rev Gastroenterol Hepatol, 2015, 12(9): 489.
9
Lee JS, Kim SH, Jun DW. Clinical implications of fatty pancreas: Correlations between fatty pancreas and metabolic syndrome [J]. World J Gastroenterol, 2009, 15(15): 1869-1875.
10
赵献萍，翟虹，崔玉敏. 超声诊断胰腺脂肪浸润的临床价值 [J] 新疆医学, 2007, 37(4): 73-74.
11
van Geenen EJ, Smits MM, Schreuder TC, et al. Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease [J] Pancreas, 2010, 39(8): 1185-1190.
12
Wang CY, Ou HY, Chen MF, et al. Enigmatic ectopic fat: prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population [J] J Am Heart Assoc, 2014, 3(1): e000297.
13
沈璐琳. 内脏脂肪综合征 [J]. 日本医学简介, 1998, 19(1): 37-38.
14
Hori M, Kitahashi T, Imai T, et al. Enhancement of carcinogenesis and fatty infiltration in the pancreas in N-nitrosobis (2-oxopropyl) amine-treated hamsters by high-fat diet [J] Pancreas, 2011, 40(8): 1234-1240.
15
Gulcan E, Gulcan A, Ozbek O. Is there a role of pancreatic steatosis together with hypertrigliceridemia on the pathogenesis of diabetes in a patient with type 2 diabetes mellitus? [J]. Medical hypotheses, 2007, 68(4): 912-923.
[1] 魏淑婕, 惠品晶, 丁亚芳, 张白, 颜燕红, 周鹏, 黄亚波. 单侧颈内动脉闭塞患者行颞浅动脉-大脑中动脉搭桥术的脑血流动力学评估[J]. 中华医学超声杂志（电子版）, 2023, 20(10): 1046-1055.
[2] 张璇, 马宇童, 苗玉倩, 张云, 吴士文, 党晓楚, 陈颖颖, 钟兆明, 王雪娟, 胡淼, 孙岩峰, 马秀珠, 吕发勤, 寇海燕. 超声对Duchenne肌营养不良儿童膈肌功能的评价[J]. 中华医学超声杂志（电子版）, 2023, 20(10): 1068-1073.
[3] 朱连华, 费翔, 韩鹏, 姜波, 李楠, 罗渝昆. 高帧频超声造影在胆囊息肉样病变中的鉴别诊断价值[J]. 中华医学超声杂志（电子版）, 2023, 20(09): 904-910.
[4] 张梅芳, 谭莹, 朱巧珍, 温昕, 袁鹰, 秦越, 郭洪波, 侯伶秀, 黄文兰, 彭桂艳, 李胜利. 早孕期胎儿头臀长正中矢状切面超声图像的人工智能质控研究[J]. 中华医学超声杂志（电子版）, 2023, 20(09): 945-950.
[5] 陈舜, 薛恩生, 叶琴. PDCA在持续改进超声危急值管理制度中的价值[J]. 中华医学超声杂志（电子版）, 2023, 20(09): 974-978.
[6] 周钰菡, 肖欢, 唐毅, 杨春江, 周娟, 朱丽容, 徐娟, 牟芳婷. 超声对儿童髋关节暂时性滑膜炎的诊断价值[J]. 中华医学超声杂志（电子版）, 2023, 20(08): 795-800.
[7] 刘欢颜, 华扬, 贾凌云, 赵新宇, 刘蓓蓓. 颈内动脉闭塞病变管腔结构和血流动力学特征分析[J]. 中华医学超声杂志（电子版）, 2023, 20(08): 809-815.
[8] 郏亚平, 曾书娥. 含鳞状细胞癌成分的乳腺化生性癌的超声与病理特征分析[J]. 中华医学超声杂志（电子版）, 2023, 20(08): 844-848.
[9] 张丽丽, 陈莉, 余美琴, 聂小艳, 王婧玲, 刘婷. PDCA循环法在超声浅表器官亚专科建设中的应用[J]. 中华医学超声杂志（电子版）, 2023, 20(07): 717-721.
[10] 罗刚, 泮思林, 陈涛涛, 许茜, 纪志娴, 王思宝, 孙玲玉. 超声心动图在胎儿心脏介入治疗室间隔完整的肺动脉闭锁中的应用[J]. 中华医学超声杂志（电子版）, 2023, 20(06): 605-609.
[11] 黄佳, 石华, 张玉国, 胡佳琪, 陈茜. 胎儿左头臂静脉正常与异常超声图像特征及其临床意义[J]. 中华医学超声杂志（电子版）, 2023, 20(06): 610-617.
[12] 袁泽, 庄丽. 超声检测胎儿脐动脉和大脑中动脉血流对胎儿宫内窘迫的诊断价值[J]. 中华医学超声杂志（电子版）, 2023, 20(06): 618-621.
[13] 蒋佳纯, 王晓冰, 陈培荣, 许世豪. 血清学指标联合常规超声及超声造影评分诊断原发性干燥综合征的临床价值[J]. 中华医学超声杂志（电子版）, 2023, 20(06): 622-630.
[14] 武壮壮, 张晓娟, 史泽洪, 史瑶, 原韶玲. 超声联合乳腺X线摄影及PR、Her-2预测高级别与中低级别乳腺导管原位癌的价值[J]. 中华医学超声杂志（电子版）, 2023, 20(06): 631-635.
[15] 尚培中, 张润萍, 张伟, 贾国洪, 李晓武, 苗建军, 刘冰. 梗阻性黄疸临床防治新技术单中心应用研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 104-107.
阅读次数
全文


摘要

版权所有 中华医学会 中华医学电子音像出版社有限责任公司  京ICP备14006079号-1  网络出版服务许可证：(署)网出证(京)字第075号