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中华医学超声杂志(电子版) ›› 2018, Vol. 15 ›› Issue (12) : 948 -952. doi: 10.3877/cma.j.issn.1672-6448.2018.12.012

所属专题: 乳腺超声 文献

浅表器官超声影像学

自动乳腺全容积成像冠状面"汇聚征"对乳腺病变的诊断价值
陈海萍1, 包凌云1,(), 程颖颖1, 许晓静1, 谭艳娟1, 朱罗茜1   
  1. 1. 310006 浙江大学医学院附属杭州市第一人民医院超声影像科
  • 收稿日期:2017-05-04 出版日期:2018-12-01
  • 通信作者: 包凌云
  • 基金资助:
    杭州市科技局项目(20170533B29)

Value of convergence sign on coronal plane images of automated breast volume scanning in diagnosis of breast lesions

Haiping Chen1, Lingyun Bao1,(), Yingying Cheng1, Xiaojing Xu1, Yanjuan Tan1, Luoxi Zhu1   

  1. 1. Department of Ultrasound, Affiliated Hangzhou First People′s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
  • Received:2017-05-04 Published:2018-12-01
  • Corresponding author: Lingyun Bao
  • About author:
    Corresponding author: Bao Lingyun, Email:
引用本文:

陈海萍, 包凌云, 程颖颖, 许晓静, 谭艳娟, 朱罗茜. 自动乳腺全容积成像冠状面"汇聚征"对乳腺病变的诊断价值[J]. 中华医学超声杂志(电子版), 2018, 15(12): 948-952.

Haiping Chen, Lingyun Bao, Yingying Cheng, Xiaojing Xu, Yanjuan Tan, Luoxi Zhu. Value of convergence sign on coronal plane images of automated breast volume scanning in diagnosis of breast lesions[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2018, 15(12): 948-952.

目的

探讨自动乳腺全容积成像冠状面"汇聚征"对乳腺病变的诊断价值。

方法

选取2011年7月至2016年7月在杭州市第一人民医院就诊的经自动乳腺全容积成像(ABVS)扫查冠状面出现"汇聚征"的乳腺病灶共124个,分为肿块型与非肿块型2组,分别与病理结果相对照,得出冠状面"汇聚征"在肿块型组及非肿块型组的乳腺癌检出率,用χ2检验进行对比分析,评估冠状面"汇聚征"对乳腺病变的鉴别诊断价值。

结果

124个乳腺病灶中89个为肿块型病变,35个为非肿块型病变。肿块型病变经病理证实为恶性71个,其中浸润性乳腺癌67个,非浸润性乳腺癌4个,良性病变18个(乳腺腺病11个,导管内乳头状瘤4个,不典型增生2个,放射状瘢痕1个),非肿块型病变经病理证实为恶性6个,其中,浸润性乳腺癌2个,非浸润性乳腺癌4个,良性病变29个(乳腺腺病25个,导管内乳头状瘤3个,纤维腺瘤1个)。冠状面"汇聚征"作为乳腺癌的一个诊断征象,在肿块型乳腺病变中的检出率为79.77%(71/89),高于非肿块型17.14%(6/35),差异有统计学意义(χ2=41.87,P<0.05)。本组共诊断77例乳腺癌,其中浸润性乳腺癌69例,非浸润性乳腺癌8例,冠状面"汇聚征"对浸润性乳腺癌的检出率为89.61%(69/77),显著高于非浸润性乳腺癌10.39%(8/77)。良性病变中,无论肿块型或非肿块型,乳腺腺病均是主要的病理类型,在肿块型中所占比例61.11%(11/18),非肿块型中86%(25/29)。

结论

冠状面"汇聚征"是乳腺癌诊断的重要超声征象,尤其对于乳腺肿块型病变,且对浸润性乳腺癌更为敏感。而良性病变中间质增生、纤维化或胶原化是是造成假阳性的主要干扰因素,其中乳腺腺病是主要的病理类型。

Objective

To assess the value of the convergence sign on coronal plane images of automated breast volume scanning for the diagnosis of breast lesions.

Methods

One hundred and twenty-four pathologically proved breast lesions, including 89 mass cases and 35 non-mass cases, were retrospectively studied. The detection rates of breast cancer in the mass cases and non-mass cases were obtained by the convergence sign on coronal plane images of automated breast volume scanning and compared with those achieved by pathology, and the chi-square test was used to evaluate its value in the diagnosis of breast lesions.

Results

In all, 89 mass cases and 35 non-mass-like cases were reviewed. In 89 mass lesions, 71 were malignant, including 67 invasive ductal carcinomas and 4 in situ ductal carcinomas, and 18 were benign, including 11 cases of adenopathy, 4 cases of intraductal papilloma, 2 cases of atypical hyperplasia, and 1 case of radial scar. In 35 non-mass cases, 6 were malignant, including 2 invasive ductal carcinomas and 4 in situ ductal carcinomas, and 29 were benign, including 25 cases of adenopathy, 3 cases of intraductal papilloma, and 1 case of adenofibroma. The convergence sign was more common in mass lesions, with a rate of 79.77% (71/89), compared with 17.14% in non-mass lesions (χ2=41.87, P<0.05). In all 77 malignant cases, the detection rate of the convergence sign in invasive cancer was 89.61% (69/77), significantly higher than that of in situ ductal carcinoma (10.39%, 8/77). In all benign cases, the main pathological type was adenopathy [61.11% (11/18) in mass lesions and 86% (25/29) in non-mass lesions].

Conclusion

The convergence sign on coronal plane images of automated breast volume scanning is an important feature for the diagnosis of breast cancer, especially for invasive ductal carcinoma, but benign lesions such as mesenchymal hyperplasia or fibrosis are the main cause of false-positives, in which adenopathy is the main pathological type.

表1 乳腺病灶的形态学分类及病理结果[个(%)]
图1~3 浸润性乳腺癌的ABVS横切面与冠状面图像以及对应的病理图像(HE ×40)。图1为自动乳腺全容积成像横切面上表现为乳腺实质性肿块;图2为冠状面上呈"汇聚征";图3为对应的病理图像,乳腺导管上皮呈大小不一巢团状在纤维性间质内不规则生长,细胞大小不一,有低-中等异型性
图4~6 导管原位癌的自动乳腺全容积成像横切面与冠状面图像以及对应的病理图像(HE ×40)。图4为自动乳腺全容积成像横切面上表现为乳腺非肿块型病变;图5为冠状面呈"汇聚征";图6为对应的病理图像:乳腺导管上皮增生,形成筛状结构,导管上皮细胞形态较一致,细胞异型性轻
图7~9 乳腺腺病的自动乳腺全容积成像图像以及对应的病理图(HE ×40)。图7为自动乳腺全容积成像横切面上表现为乳腺非肿块型病变;图8为冠状面呈"汇聚征";图9为对应的病理图:大小不一的乳腺导管不规则增生,部分导管上皮伴有普通型增生,双层细胞明显,无明显细胞异型性
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