Assessment of fetal lung development in using two-dimensional ultrasonography

doi:10.3877/cma.j.issn.1672-6448.2014.04.012

Abstract

Abstract:

Objective

To explore the application value of two-dimensional ultrasonic measurement of fetal left and right lung area, left and right pulmonary longitudinal diameter, left and right lung volume and total lung volume in evaluation of fetal lung development.

Methods

In 489 cases of normal singleton pregnancy, two-dimensional ultrasound scanning were conducted at 12-40 weeks. The left and right lung area was traced in the four chamber view using Trace method. The distances of left diaphragmatic dome to left lung apex and the right diaphragmatic dome to right lung apex were measured respectively on the left and right fetal lung parasagittal planes. Then calculation of left and right lung volume and total lung volume was carried out.

Results

Spearman correlation coefficient of gestational age and left and right lung area, left and right pulmonary longitudinal diameter, left lung volume and total lung volume were 0.929, 0.923, 0.923, 0.917, 0.946, 0.943, 0.951, and a positive correlation, with statistical significance (P<0.05). At 12-40 weeks, fetal left and right lung area, left and right pulmonary longitudinal diameter, left and right lung volume and total lung volume increased with gestational age and fetal growth. Pulmonary area increased faster before 26 weeks than that after 26 weeks. Pulmonary longitudinal diameter and lung volume grew at a constant rate throughout pregnancy, but the growth rate of pulmonary longitudinal diameter was slightly faster than that of lung volume. The fifth, twenty-fifth, fiftieth, seventy-fifth, ninety-fifth percentile of fetal left and right lung volume and total lung volume at 12-40 weeks were obtained.

Conclusions

Fetal left and right lung area, left and right pulmonary longitudinal diameter, left and right lung volume and total lung volume were positively correlated with gestational age between 12 and 40 week. The normal values of lung volume and total lung volume provide a reference index for prenatal diagnosis of fetal pulmonary hypoplasia. The fetal four chamber view and fetal left parasagittal section was easy to obtain, and may serve as a new conventional method in evaluating fetal lung developments.

Key words: Ultrasonography, Fetus, Lung, Fetal development

Hua Zhong, Xiaoyan Ma, Haichun Zhang, Zhen Xiao. Assessment of fetal lung development in using two-dimensional ultrasonography[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2015, 12(04): 312-318.

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URL: https://chaosheng.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1672-6448.2014.04.012

https://chaosheng.cma-cmc.com.cn/EN/Y2015/V12/I04/312

Figures/Tables 6

References 17

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统计分析指标	面积（cm²）		纵径（cm）		体积（cm³）		总肺体积（cm³）
统计分析指标	左肺	右肺	左肺	右肺	左肺	右肺	总肺体积（cm³）
Spearson相关系数	0.929	0.923	0.923	0.917	0.946	0.943	0.951
P值	0.000	0.000	0.000	0.000	0.000	0.000	0.000

统计分析指标	面积（cm²）		纵径（cm）		体积（cm³）		总肺体积（cm³）
统计分析指标	左肺	右肺	左肺	右肺	左肺	右肺	总肺体积（cm³）
Spearson相关系数	0.929	0.923	0.923	0.917	0.946	0.943	0.951
P值	0.000	0.000	0.000	0.000	0.000	0.000	0.000

孕周（周）	例数	第5百分位数	第25百分位数	第50百分位数	第75百分位数	第95百分位数
12	22	0.10	0.16	0.20	0.30	0.49
13	30	0.17	0.21	0.26	0.34	0.50
14	8	0.20	0.25	0.36	0.56	0.76
15	4	0.49	0.56	0.82	0.85	0.86
16	7	0.59	0.66	1.03	1.54	1.56
17	12	0.67	1.09	1.36	1.49	1.97
18	11	1.33	1.65	1.83	2.19	2.77
19	14	1.29	1.54	2.10	2.93	3.64
20	18	1.85	2.38	2.68	3.43	7.39
21	10	1.95	2.08	2.75	3.60	4.88
22	10	2.61	3.16	3.90	4.55	5.17
23	34	2.64	3.50	4.30	4.82	5.88
24	64	3.46	4.68	5.13	6.51	10.16
25	49	4.01	4.84	6.15	7.06	12.33
26	17	3.55	5.38	6.09	6.69	9.37
27	9	4.85	7.20	8.16	13.69	16.63
28	9	6.89	7.93	9.42	12.07	14.90
29	16	5.66	7.87	9.09	12.85	23.72
30	7	8.05	8.34	11.42	18.42	19.51
31	13	7.96	9.65	11.66	15.59	21.22
32	18	7.96	11.84	14.49	16.37	26.79
33	11	10.35	12.38	13.51	16.32	20.94
34	21	8.56	14.81	18.86	22.72	26.82
35	9	8.99	12.10	13.71	23.12	26.41
36	18	11.61	14.74	17.16	20.52	32.81
37	19	12.83	18.86	19.89	23.88	37.99
38	11	13.63	15.57	21.48	23.47	30.31
39	15	13.49	15.00	19.31	24.73	46.44
40	3	21.69	21.69	22.17	22.34	22.34

孕周（周）	例数	第5百分位数	第25百分位数	第50百分位数	第75百分位数	第95百分位数
12	22	0.10	0.16	0.20	0.30	0.49
13	30	0.17	0.21	0.26	0.34	0.50
14	8	0.20	0.25	0.36	0.56	0.76
15	4	0.49	0.56	0.82	0.85	0.86
16	7	0.59	0.66	1.03	1.54	1.56
17	12	0.67	1.09	1.36	1.49	1.97
18	11	1.33	1.65	1.83	2.19	2.77
19	14	1.29	1.54	2.10	2.93	3.64
20	18	1.85	2.38	2.68	3.43	7.39
21	10	1.95	2.08	2.75	3.60	4.88
22	10	2.61	3.16	3.90	4.55	5.17
23	34	2.64	3.50	4.30	4.82	5.88
24	64	3.46	4.68	5.13	6.51	10.16
25	49	4.01	4.84	6.15	7.06	12.33
26	17	3.55	5.38	6.09	6.69	9.37
27	9	4.85	7.20	8.16	13.69	16.63
28	9	6.89	7.93	9.42	12.07	14.90
29	16	5.66	7.87	9.09	12.85	23.72
30	7	8.05	8.34	11.42	18.42	19.51
31	13	7.96	9.65	11.66	15.59	21.22
32	18	7.96	11.84	14.49	16.37	26.79
33	11	10.35	12.38	13.51	16.32	20.94
34	21	8.56	14.81	18.86	22.72	26.82
35	9	8.99	12.10	13.71	23.12	26.41
36	18	11.61	14.74	17.16	20.52	32.81
37	19	12.83	18.86	19.89	23.88	37.99
38	11	13.63	15.57	21.48	23.47	30.31
39	15	13.49	15.00	19.31	24.73	46.44
40	3	21.69	21.69	22.17	22.34	22.34

孕周（周）	例数	第5百分位数	第25百分位数	第50百分位数	第75百分位数	第95百分位数
12	22	0.11	0.19	0.24	0.44	0.63
13	30	0.18	0.26	0.35	0.47	0.72
14	8	0.21	0.44	0.62	0.90	1.05
15	4	0.61	0.68	0.94	1.12	1.16
16	7	0.84	0.84	1.58	1.80	1.86
17	12	1.02	1.31	1.73	1.86	2.76
18	11	1.61	1.84	2.34	2.79	4.00
19	14	1.80	2.35	2.69	3.29	4.19
20	18	2.05	3.17	3.86	4.45	8.44
21	10	2.71	3.33	4.59	4.97	9.72
22	10	3.42	4.54	5.46	6.74	7.99
23	34	3.23	4.96	6.50	7.50	10.03
24	64	5.30	6.34	7.65	9.55	15.54
25	49	5.38	7.67	9.47	12.12	17.99
26	17	6.00	7.66	8.80	10.87	14.21
27	9	6.74	8.20	12.18	17.45	21.80
28	9	9.32	12.48	14.60	19.53	20.40
29	16	10.44	12.74	14.62	20.79	29.95
30	7	10.11	12.98	19.02	25.57	27.19
31	13	9.56	13.52	16.98	22.84	26.47
32	18	14.31	18.06	20.39	27.06	36.01
33	11	11.72	16.09	20.22	22.41	27.81
34	21	15.00	19.04	22.87	26.39	38.14
35	9	14.67	16.72	18.03	24.27	37.28
36	18	13.79	23.86	27.89	34.79	56.87
37	19	18.84	22.54	26.48	32.02	47.82
38	11	15.17	19.56	31.13	34.95	53.73
39	15	13.95	21.63	27.04	36.75	52.00
40	3	23.63	23.63	27.98	30.30	30.30

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