切换至 "中华医学电子期刊资源库"

中华医学超声杂志(电子版) ›› 2020, Vol. 17 ›› Issue (11) : 1095 -1102. doi: 10.3877/cma.j.issn.1672-6448.2020.11.008

所属专题: 文献

妇产科超声影像学

内寄生胎产前超声影像学特征与病理对照分析
包艳娟1, 杨小红1,(), 杨帆1, 陈欣林1, 陈佩文1, 赵胜1, 朱霞1, 张晓燕1   
  1. 1. 430000 武汉,湖北省妇幼保健院超声科
  • 收稿日期:2019-04-03 出版日期:2020-11-01
  • 通信作者: 杨小红
  • 基金资助:
    湖北省卫生计生科研基金资助(WJ2018H0148)

Prenatal ultrasonic characteristics and pathological analysis of fetus in fetu

Yanjuan Bao1, Xiaohong Yang1,(), Fan Yang1, Xinlin Chen1, Peiwen Chen1, Sheng Zhao1, Xia Zhu1, Xiaoyan Zhang1   

  1. 1. Department of Ultrasonography, Maternal and Child Health Hospital of Hubei Province, Wuhan 430000, China
  • Received:2019-04-03 Published:2020-11-01
  • Corresponding author: Xiaohong Yang
  • About author:
    Corresponding author: Yang Xiaohong, Email:
引用本文:

包艳娟, 杨小红, 杨帆, 陈欣林, 陈佩文, 赵胜, 朱霞, 张晓燕. 内寄生胎产前超声影像学特征与病理对照分析[J/OL]. 中华医学超声杂志(电子版), 2020, 17(11): 1095-1102.

Yanjuan Bao, Xiaohong Yang, Fan Yang, Xinlin Chen, Peiwen Chen, Sheng Zhao, Xia Zhu, Xiaoyan Zhang. Prenatal ultrasonic characteristics and pathological analysis of fetus in fetu[J/OL]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2020, 17(11): 1095-1102.

目的

总结内寄生胎产前超声影像学特征。

方法

对2009年1月至2019年1月湖北省妇幼保健院产前超声检出胎体肿块,并经出生后手术及引产后病理检查证实的8例内寄生胎影像诊断资料进行回顾性分析。

结果

产前超声声像图显示:8例胎儿胎体肿块均为囊实性,位于腹膜后4例,位于骶尾部2例,位于面部2例;最早发现胎体肿块为孕18+2周;其中2例发现胎体肿块为临产前。肿块最小径1.1 cm×1.1 cm,最大径16.0 cm×10.0 cm;与周围组织分界清,肿块增大致周围脏器不同程度受压移位。超声诊断:8例胎儿胎体肿块中4例最早于孕22+2周精准诊断为内寄生胎;2例胎体肿块产前诊断为畸胎瘤;2例骶尾部肿块产前鉴别不清是畸胎瘤或内寄生胎。临床结局:4例腹膜后胎体肿块在宿主胎儿出生后手术康复,随访至今未见复发;其余4例超声检查后引产。出生后检查:8例宿主胎儿共10个寄生胎,2例为双寄生胎;病理检查显示寄生胎内最多的组织是骨或软骨和肢芽(9/10);其次为脊柱轴、皮肤和血管蒂(7/10),四肢长骨和毛发(6/10),肠管(5/10)。产前超声与产后病理诊断结果对照:产前超声正确诊断内寄生胎4例(4/8),寄生胎5个(5/10)。病理补充超声影像显示6个寄生胎有毛发、5个有肠管、1个有肾、合并畸形2个有脐膨出、2个为无脑畸形;1个寄生胎产前超声未检出闭合性脊髓脊膜膨出;1例产前超声认为是大寄生胎的骨性结构,出生后病理证实为双内寄生胎的小寄生胎,其脊柱轴为发育不全椎骨融合而成。

结论

内寄生胎产前超声声像图有特征性表现,系统规范的产前超声对临床咨询和胎儿出生后选择手术治疗有重要意义。

Objective

To summarize the prenatal ultrasonic characteristics of fetus in fetu (FIF).

Methods

The ultrasound images of eight cases of pathologically-confirmed FIF were retrospectively analyzed at Maternal and Child Health Hospital of Hubei Province from January 2009 to January 2019.

Results

Eight cases of FIF were enrolled in this retrospective study. Ultrasonic imaging showed heterogeneous cystic-solid masses with clear boundaries. The locations of masses included the retroperitoneum (4 cases), sacrococcygeal region (2 cases), and face (2 cases). In the 8 patients, 10 cystic-solid masses in fetus were found by ultrasound at different times of gestation from 18+ 2 to 38+ 1 weeks, with 2 cases having 2 parasites each. The size of masses ranged from the minimum of 1.1 cm×1.1 cm to the maximum of 16.0 cm×10.0 cm. The surrounding organs were compressed differently as a result of the mass effect. Four cases were diagnosed as FIF by prenatal ultrasound, 2 cases were thought to be teratomas, and 2 cases had an unclear diagnosis. The 4 cases with FIF in the retroperitoneum underwent surgery after birth and recovered with no recurrence, and the other 4 cases underwent induced labors. Pathologically, different organ components were found in 10 parasites, including bone/cartilage and limb buds (9/10), vertebral column, skin and vessels (7/10), long bones and hairs (6/10), and intestinal tracts (5/10). The coincidence rates between prenatal ultrasound and pathology were 8/9 cases of bone/cartilage, 6/7 cases of vertebral column, 5/6 cases of axial skeleton, and 5/7 cases of skin and vessels. Prenatal ultrasound failed to detect some organs, including hairs in 6 parasites, intestinal tracts in 5, kidney in 1, and combined malformations in 5 (umbilical bulge in 2 parasites, anencephalus in 2, and spina bififida in 1). One smaller parasite of twin FIF was misdiagnosed as the bony structure of a large parasitic fetus in prenatal ultrasound.

Conclusion

Ultrasonic manifestations of FIF are characteristic and systemic prenatal ultrasound has a very important role in the diagnosis of FIF.

图1 腹膜后胎中胎产前超声声像图及术中病理标本图。图a孕25+2周,声像图示胎儿左侧腹腔内囊实性肿块,测量键处为实质性部分,内有钙化斑;图b孕40+4周,声像图示胎儿左侧腹腔内囊实性肿块明显增大,实质部分具有胎儿雏形,可分出水肿皮肤、脊柱、股骨及肢体;图c动脉频谱示寄生胎内可见脐带样血管蒂及朝向寄生胎体内;图d出生后手术病理标本示左侧腹膜后肿块为胎中胎,寄生胎可见水肿皮肤、毛发、脐膨出、下肢、脊柱,并有脐带样血管蒂与宿主相连(镊尖所指处)
图2 骶尾部胎中胎产前超声声像图、引产后标本图及三维CT重建影像图。图a孕18+6周,声像图示胎儿骶尾部囊实性肿块,内见散在强回声斑(M为肿块中实质性成份);图b孕20+1周,声像图示胎体肿块明显增大,实质性成份增多,内见长骨状强回声(测量键处);图c孕21周,引产后大体标本示胎儿骶尾部一实性为主的肿块,内有软骨样结构,并见肢芽(红箭头所示),肿块包膜不完整,为引产过程中损伤所致;图d引产后胎儿大体标本三维CT重建图示胎儿骶尾部肿块,内见散在骨性结构,无脊柱轴,见肢芽(红箭头所示)
图3 腹膜后双寄生胎出生后彩色多普勒、三维超声图像及手术后大体标本。图a出生后第5天,彩色多普勒声像图分别显示2个寄生胎(A、B)的脐带样血管蒂结构;图b出生后第5天,三维超声声像图显示2个寄生胎(A、B)及肢芽(蓝箭头所示);图c出生后第12天手术,胎体肿块大体标本可见纤维膜、血管蒂及2个寄生胎,A寄生胎见4个肢芽、不完整皮肤及畸形外生殖器,B寄生胎可见2个肢芽及不完整皮肤;图d胎体肿块大体标本CT三维骨骼重建,2个寄生胎均可见脊柱轴及长骨结构,其中A寄生胎可见多条肋骨结构
表1 8例胎儿临床检查资料、产前及出生后超声检查结果
表2 8例胎儿的10个寄生胎产前超声与产后病理检查结果(检出个数/寄生胎个数)
1
Chen CP, Chern SR, Liu FF, et al. Prenatal diagnosis, pathology, and genetic study of fetus in fetu [J]. Prenat Diagn, 1997, 17(1): 13-21.
2
赵蕾,肖梅,杨小红. 妊娠期诊断寄生胎一例 [J]. 中华妇产科杂志, 2018, 53(6): 420.
3
Traisrisilp K, Srisupundit K, Suwansirikul S, et al. Intracranial fetus-in-fetu with numerous fully developed organs [J]. J Clin Ultrasound, 2018, 46(7): 487-493.
4
李明明,陈娇,胡培, 等. 产前超声诊断面部寄生胎1例 [J]. 中华超声影像学杂志, 2017, 26(11): 8.
5
WilliS RA. The borderland of embryology and pathology [J]. Bull N Y Acad Med, 1950, 26(7): 440-460.
6
Miura S, Miura K, Yamamoto T, et al. Origin and mechanisms of formation of fetus-in-fetu: two cases with genotype and methylation analyses [J]. Am J Med Genet A, 2006, 140(16): 1737-1743.
7
Spencer R. Parasitic conjoined twins: external, internal (fetuses in fetu and teratomas), and detached (acardiacs) [J]. Clin Anat, 2001, 14(6): 428-444.
8
Hoeffel CC, Nguyen KQ, Phan HT, et al. Fetus in fetu: a case report and literature review [J]. Pediatrics, 2000, 105(6): 1335-1344.
9
Brand A, Alves MC, Saraiva C, et al. Fetus in fetu--diagnostic criteria and differential diagnosis-a case report and literature review [J]. J Pediatr Surg, 2004, 39(4): 616-618.
10
Willis RA. The structure of teratomata [J]. J Pathol Bacteriol, 1935, 40(1): 36.
11
Nicolini U, Dell′Agnola CA, Ferrazzi E, et al. Ultrasonic prenatal diagnosis of fetus in fetu [J]. J Clin Ultrasound, 1983, 11(6): 321-322.
12
Harigovind D, Babu Sp H, Nair SV, et al. Fetus in fetu - a rare developmental anomaly [J]. Radiol Case Rep, 2018, 14(3): 333-336.
13
Yaacob R, Zainal Mokhtar A, Abang Jamari DZH, et al. The entrapped twin: a case of fetus-in-fetu [J]. BMJ Case Rep, 2017 (Sep 23): 2017.
14
Ji Y, Song B, Chen S, et al. Fetus in Fetu in the Scrotal Sac: Case Report and Literature Review [J]. Medicine (Baltimore), 2015, 94(32): e1322.
15
Nastanski F, Downey EC. Fetus in fetu: a rare cause of a neonatal mass [J]. Ultrasound Obstet Gynecol, 2001, 18(1): 72-75.
16
Hopkins KL, Dickson PK, Ball TI, et al. Fetus-in-fetu with malignant recurrence [J]. J Pediatr Surg, 1997, 32(10): 1476-1479.
17
Sharma N, Verma P, Pathak P. 27 cm fetus in fetu presenting in a 36-year-old man: report of a rare case and brief review of literature [J]. Indian J Surg, 2007, 69(4): 155-157.
[1] 王亚红, 蔡胜, 葛志通, 杨筱, 李建初. 颅骨骨膜窦的超声表现一例[J/OL]. 中华医学超声杂志(电子版), 2024, 21(11): 1089-1091.
[2] 章建全, 程杰, 陈红琼, 闫磊. 采用ACR-TIRADS评估甲状腺消融区的调查研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 966-971.
[3] 罗辉, 方晔. 品管圈在提高甲状腺结节细针穿刺检出率中的应用[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 972-977.
[4] 杨忠, 时敬业, 邓学东, 姜纬, 殷林亮, 潘琦, 梁泓, 马建芳, 王珍奇, 张俊, 董姗姗. 产前超声在胎儿22q11.2 微缺失综合征中的应用价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(09): 852-858.
[5] 孙佳丽, 金琳, 沈崔琴, 陈晴晴, 林艳萍, 李朝军, 徐栋. 机器人辅助超声引导下经皮穿刺的体外实验研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(09): 884-889.
[6] 史学兵, 谢迎东, 谢霓, 徐超丽, 杨斌, 孙帼. 声辐射力弹性成像对不可切除肝细胞癌门静脉癌栓患者放射治疗效果的评价[J/OL]. 中华医学超声杂志(电子版), 2024, 21(08): 778-784.
[7] 顾莉莉, 姜凡. 安徽省超声产前筛查切面图像质量现状调查情况及分析[J/OL]. 中华医学超声杂志(电子版), 2024, 21(07): 671-674.
[8] 赵林娟, 吕婕, 王文胜, 马德茂, 侯涛. 超声引导下染色剂标记切缘的梭柱型和圆柱型保乳区段切除术的效果研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 634-637.
[9] 屈翔宇, 张懿刚, 李浩令, 邱天, 谈燚. USP24及其共表达肿瘤代谢基因在肝细胞癌中的诊断和预后预测作用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 659-662.
[10] 熊鹰, 林敬莱, 白奇, 郭剑明, 王烁. 肾癌自动化病理诊断:AI离临床还有多远?[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(06): 535-540.
[11] 袁雨涵, 杨盛力. 体液和组织蛋白质组学分析在肝癌早期分子诊断中的研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 883-888.
[12] 李浩, 陈棋帅, 费发珠, 张宁伟, 李元东, 王硕晨, 任宾. 慢性肝病肝纤维化无创诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 863-867.
[13] 谭瑞义. 小细胞骨肉瘤诊断及治疗研究现状与进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(08): 781-784.
[14] 王子阳, 王宏宾, 刘晓旌. 血清标志物对甲胎蛋白阴性肝细胞癌诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 677-681.
[15] 陈慧, 邹祖鹏, 周田田, 张艺丹, 张海萍. 皮肤镜对头皮红斑性皮肤病辅助鉴别诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 692-698.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?