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中华医学超声杂志(电子版) ›› 2025, Vol. 22 ›› Issue (10) : 962 -968. doi: 10.3877/cma.j.issn.1672-6448.2025.10.009

妇产科超声影像学

胆道闭锁产前及生后超声诊断分析
姚垚, 杨小红(), 赵胜, 高艳多, 郭凯莉   
  1. 430070 武汉,湖北省妇幼保健院超声诊断科
  • 收稿日期:2025-05-29 出版日期:2025-10-01
  • 通信作者: 杨小红
  • 基金资助:
    湖北省卫生健康委员会(WJ2023Z007); 湖北省科技厅项目(2025AFD847)

Prenatal and postnatal ultrasound diagnosis of biliary atresia

Yao Yao, Xiaohong Yang(), Sheng Zhao, Yanduo Gao, Kaili Guo   

  1. Ultrasound Diagnostic Department, Hubei Maternal and Health Care Hospital, Wuhan 430070, China
  • Received:2025-05-29 Published:2025-10-01
  • Corresponding author: Xiaohong Yang
引用本文:

姚垚, 杨小红, 赵胜, 高艳多, 郭凯莉. 胆道闭锁产前及生后超声诊断分析[J/OL]. 中华医学超声杂志(电子版), 2025, 22(10): 962-968.

Yao Yao, Xiaohong Yang, Sheng Zhao, Yanduo Gao, Kaili Guo. Prenatal and postnatal ultrasound diagnosis of biliary atresia[J/OL]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2025, 22(10): 962-968.

目的

分析胆道闭锁产前及生后超声影像特征,探讨胆道闭锁产前超声诊断线索。

方法

回顾性分析2021年3月至2025年3月在湖北省妇幼保健院进行产前超声检查并经手术确诊的8例胆道闭锁患儿的产前及生后超声声像图。

结果

8例中3例产前超声检查未检出明显异常。5例产前超声发现胆道系统异常,其中2例产前2次或3次超声提示胆囊显示不清或隐约可见胆囊声像;3例产前超声提示胆囊显示不清或见形态僵硬胆囊并肝门区不规则无回声。8例生后超声均提示胆囊异常(胆囊显示不清、胆囊形态僵硬或小胆囊)、肝门区纤维条索征、胆囊收缩功能异常及肝动脉扩张,生后3例肝门区见无回声。

结论

产前胆囊未显示、胆囊未显示合并肝门区无回声或胆囊形态僵硬合并肝门区无回声时,均应怀疑胆道闭锁可能性。产前超声诊断胆道闭锁较为困难,产前可疑胆道异常的病例,出生后需密切关注新生儿黄疸及大便情况,超声复查胆囊,做到早发现、早诊断、早治疗。

Objective

To analyze the prenatal and postnatal ultrasonic imaging features of biliary atresia, and explore the prenatal ultrasonic diagnostic clues for this condition.

Methods

A retrospective analysis was conducted on the prenatal and postnatal ultrasound sonograms of 8 children who underwent prenatal ultrasound examinations at Hubei Provincial Maternal and Child Health Hospital from March 2021 to March 2025 and were diagnosed with biliary atresia by surgery.

Results

Of the 8 cases, 3 showed no obvious abnormalities on prenatal ultrasound. Abnormalities in the biliary system were identified by prenatal ultrasound in 5 cases, among which 2 had prenatal ultrasound examinations (conducted 2 or 3 times) indicating that the gallbladder was not clearly visualized or only faintly visible. The remaining 3 cases had prenatal ultrasound findings suggesting either unclear visualization of the gallbladder, or the presence of a gallbladder with rigid morphology accompanied by irregular anechoic areas in the hepatic hilum. Ultrasonography performed on all 8 infants after birth revealed gallbladder abnormalities (including unclear visualization of the gallbladder, rigid gallbladder morphology, or a small gallbladder), fibrous cord sign in the hepatic hilar region, abnormal gallbladder contraction function, and hepatic artery dilatation. Among them, anechoic areas in the hepatic hilar region were observed in 3 infants after birth.

Conclusion

When the fetal gallbladder is not visualized prenatally, non-visualization of the gallbladder is accompanied by anechoic areas in the hepatic hilum, or the gallbladder has a rigid morphology combined with anechoic areas in the hepatic hilum, the possibility of biliary atresia should be suspected. Prenatal ultrasound diagnosis of biliary atresia is relatively difficult. For cases with suspected biliary abnormalities identified prenatally, close attention should be paid to neonatal jaundice and stool characteristics after birth, and a follow-up ultrasound examination of the gallbladder is necessary. This aims to achieve early detection, early diagnosis, and early treatment of the condition.

图1 胆道闭锁(病例2)产前及生后超声图像。图a为24+2周胎儿腹部横切面探查可见一稍偏小的胆囊回声;图b为生后30 d高频探头经腹部探查可见一僵硬胆囊,囊壁呈锯齿形,另可见肝门区纤维条索征(黄色箭头);图c为高频探头经腹部探查患儿肝脏,彩色多普勒血流成像提示肝包膜下可见丰富血流信号 注:GB为胆囊
图2 胆道闭锁(病例5)产前及生后超声图像。图a为22+4周胎儿腹部横切面超声未探及胆囊回声;图b为33周胎儿腹部横切面隐约可见胆囊(白色小箭头);图c为出生后4 d,经高频探头腹部探查可见一厚壁的胆囊回声,肝门区可见纤维条索征(黄色箭头) 注:GB为胆囊
图3 胆道闭锁(病例6)产前及生后超声图像。图a为12+4周胎儿腹部斜切面可见肝门区无回声,未见明显胆囊回声;图b为胎儿腹部旁矢状切面显示肝门区无回声;图c、d分别为22+4、28+6周经腹部横切面均可见正常胆囊回声;图e为出生后25 d经腹部肋间斜切面可见稍僵硬胆囊;图f为出生后25 d经腹部肋下斜切面可见肝门区纤维条索征(黄色箭头)、形态僵硬的胆囊以及肝内无回声(白色箭头) 注:st为胃泡;C为肝门区无回声;GB为胆囊
表1 8例胆道闭锁病例产前超声表现
表2 8例胆道闭锁病例生后超声表现
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