总结胎儿静脉导管（DV）汇入异常的产前超声及临床特征，并分析其意义与价值。

回顾性分析重庆市妇幼保健院2017年1月至2024年6月产前超声诊断为DV汇入异常的64例病例的临床资料。分析其产前超声特征、合并结构异常、遗传学检查及妊娠结局。

64例DV汇入异常病例中，56.25%（36/64）为异常汇入下腔静脉，9.38%（6/64）为异常汇入冠状静脉窦，21.88%（14/64）为异常汇入肝静脉，12.50%（8/64）为异常汇入右心房。64例中23例为单纯性DV汇入异常（23/64，35.94%），32例胎儿合并有其他复杂心血管异常，20例胎儿合并其他心外异常，同时合并心内、心外异常的有11例。64例胎儿中10例行唐氏综合征血清学筛查（其中2例高风险），26例行产前羊水穿刺检测（其中7例检出异常）。64例胎儿中26例引产，38例出生，其中生后37例随访DV自然关闭未见明显发育异常（20例为单纯性DV汇入异常），另有1例出生后因肺出血死亡，为DV汇入异常合并室间隔大缺损和单脐动脉。单纯性DV汇入异常组活产率（20/23，86.96%）显著高于合并结构异常组（18/41，43.90%），差异有统计学意义（P=0.001）。

产前超声检查可确定DV异常汇入部位、评估合并结构异常情况，在胎儿DV走行异常诊断中具有重要价值。胎儿DV汇入异常可合并心内、心外异常，并与染色体异常具有一定的相关性，单纯性DV汇入异常预后较好。

To investigate the prenatal ultrasound and clinical features of fetal anomalous connection of the ductus venosus (DV) nd evaluate their clinical significance and value.

A retrospective analysis was conducted on clinical data from 64 fetuses diagnosed with anomalous DV connection by prenatal ultrasound at Chongqing Health Center for Women and Children between January 2017 and June 2024. Prenatal ultrasound features, associated structural anomalies, genetic examinations, and pregnancy outcomes were analyzed.

Among the 64 cases of anomalous connection of the DV included, 56.25% (36/64) had abnormal connection to the inferior vena cava, 9.38% (6/64) demonstrated abnormal connection to the coronary sinus, 21.88% (14/64) exhibited abnormal connection to the hepatic vein, and 12.50% (8/64) showed abnormal connection to the right atrium; 23 (23/64, 35.94%) had isolated anomalous DV connection, 32 had other complex cardiovascular abnormalities, 20 had other extracardiac abnormalities, and 11 had both intracardiac and extracardiac abnormalities; 10 underwent serological screening for Down's syndrome (2 of which were high-risk), and 26 underwent amniocentesis, with 7 cases showing abnormal results; 26 pregnancies were terminated, and 38 resulted in live births. Thirty-seven of the live-born infants showed spontaneous closure of the DV during follow-up with no obvious developmental abnormalities (20 of them had isolated anomalous DV connection). One infant died of pulmonary hemorrhage after birth, with anomalous DV connection combined with large ventricular septal defect and single umbilical artery. Notably, the live birth rate in the isolated DV anomalous connection group (20/23, 86.96%) was significantly higher than that in the group with associated structural anomalies (18/41, 43.90%) (P=0.001).

Prenatal ultrasound can identify anomalous DV connection and evaluate associated structural anomalies, and is of great value in the diagnosis of abnormal DV course. Fetal anomalous DV connection may be complicated by cardiac and extracardiac anomalies and is associated with potential chromosomal abnormalities. Isolated anomalous DV connection has a favorable prognosis.