切换至 "中华医学电子期刊资源库"

中华医学超声杂志(电子版) ›› 2022, Vol. 19 ›› Issue (06) : 521 -526. doi: 10.3877/cma.j.issn.1672-6448.2022.06.006

心血管超声影像学

超声心动图左心室压力-应变环对正常高值血压及高血压患者心肌做功的评价
丁雪晏1, 李一丹1, 孙兰兰1, 叶晓光1, 蔡绮哲1, 秦芸芸1, 李沅芝1, 王江涛2, 吕秀章1,()   
  1. 1. 100020 首都医科大学附属北京朝阳医院心脏超声科
    2. 100176 北京,通用电气医疗心血管超声临床科研部
  • 收稿日期:2020-10-20 出版日期:2022-06-01
  • 通信作者: 吕秀章
  • 基金资助:
    北京市医院管理局临床技术创新项目(XMLX201827)

Assessment of myocardial work in high normal blood pressure and hypertension patients by echocardiographic left ventricular pressure-strain loop

Xueyan Ding1, Yidan Li1, Lanlan Sun1, Xiaoguang Ye1, Qizhe Cai1, Yunyun Qin1, Yuanzhi Li1, Jiangtao Wang2, Xiuzhang Lyu1,()   

  1. 1. Department of Echocardiography, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
    2. Department of Clinical Research, General Electrics Cardiovascular Ultrasound, Beijing 100176, China
  • Received:2020-10-20 Published:2022-06-01
  • Corresponding author: Xiuzhang Lyu
引用本文:

丁雪晏, 李一丹, 孙兰兰, 叶晓光, 蔡绮哲, 秦芸芸, 李沅芝, 王江涛, 吕秀章. 超声心动图左心室压力-应变环对正常高值血压及高血压患者心肌做功的评价[J/OL]. 中华医学超声杂志(电子版), 2022, 19(06): 521-526.

Xueyan Ding, Yidan Li, Lanlan Sun, Xiaoguang Ye, Qizhe Cai, Yunyun Qin, Yuanzhi Li, Jiangtao Wang, Xiuzhang Lyu. Assessment of myocardial work in high normal blood pressure and hypertension patients by echocardiographic left ventricular pressure-strain loop[J/OL]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2022, 19(06): 521-526.

目的

应用超声心动图左心室压力-应变环(PSL)评价正常高值血压及高血压患者心肌做功。

方法

选取2019年8月至2020年3月于首都医科大学附属北京朝阳医院行超声心动图检查的高血压患者45例(高血压组),纳入同期正常高值血压患者40例(正常高值血压组)和正常血压受试者30例(正常血压组)。所有纳入对象均进行超声心动图检查。测量常规超声心动图参数,应用二维斑点追踪超声心动图测量受试者左心室整体长轴应变(GLS)、机械离散度(MD);通过左心室PSL评价心肌做功参数,包括心肌整体做功指数(GWI)、整体有效做功(GCW)、整体无效做功(GWW)、整体做功效率(GWE)。比较3组间超声心动图参数以及心肌应变和心肌做功参数,分析心肌做功参数与常规超声心动图参数和心肌应变参数的相关性。

结果

正常血压组、高值血压组、高血压组GLS呈减低趋势,但3组间差异无统计学意义(P>0.05)。高血压组较正常血压组、高值血压组MD增大,差异均有统计学意义(P均<0.05)。高值血压组较正常血压组GWI、GCW增加(P均<0.05)。高血压组较正常血压组GWI、GCW、GWW增加,GWE减低,差异均有统计学意义(P均<0.05);较高值血压组GCW、GWW增加,GWE减低,差异均有统计学意义(P均<0.05)。高血压组中,GWI、GCW分别与GLS(r=0.695、0.691,P<0.001)、LVEF(r=0.409、0.406,P=0.001)呈正相关。GWW与GLS呈负相关(r=-0.306,P<0.05),与MD呈正相关(r=0.384,P=0.002)。GWE与GLS呈正相关(r=0.519,P<0.001),与MD呈负相关(r=-0.482,P<0.001)。

结论

正常高值血压患者心肌做功效率仍正常,而高血压患者心肌做功效率受损,能量损失增加。超声心动图左心室PSL定量评价心肌做功可为正常高值血压及高血压患者心脏功能评估提供更多有价值的信息。

Objective

To evaluate myocardial work by echocardiographic left ventricular pressure-strain loop (PSL) in patients with high normal blood pressure and hypertension.

Methods

Forty-five patients with hypertension (hypertension group) who underwent echocardiography at Beijing Chaoyang Hospital Affiliated to Capital Medical University from August 2019 to March 2020 were selected retrospectively. Forty patients with high normal blood pressure (high normal blood pressure group) and 30 subjects with normal blood pressure (normal blood pressure group) were included in the same period and received echocardiography. The parameters of conventional echocardiography were measured, and the left ventricular global longitudinal strain (GLS) and mechanical dispersion (MD) were assessed by speckle tracking echocardiography. The left ventricular PSL was used to evaluate myocardial work parameters, including global work index (GWI), global constructive work (GCW), global waste work (GWW), and global work efficiency (GWE). Echocardiographic parameters, myocardial strain parameters, and myocardial work parameters were compared among the three groups, and the correlation of myocardial work parameters with conventional echocardiographic parameters and myocardial strain parameters was analyzed.

Results

GLS decreased successively in the normal blood pressure group, high normal blood pressure group, and hypertension group, but there was no significant difference among the three groups (P>0.05). MD was significantly higher in the hypertension group than in the normal blood pressure group and high normal blood pressure group (P<0.05). Compared with normal blood pressure group, GWI and GCW were increased (P<0.05) in the high normal blood pressure group. GWI, GCW, and GWW were increased, while GWE was decreased in the hypertension group (P<0.05) compared with the normal blood pressure group. GCW and GWW were increased and GWE was decreased in the high normal blood pressure group (P<0.05) compared with the high normal blood pressure group. In the hypertension group, GWI and GCW were positively correlated with GLS (r=0.695 and r=0.691, P<0.001) and LVEF (r=0.409 and r=0.406, P=0.001). GWW was negatively correlated with GLS (r=-0.306, P<0.05), and positively correlated with MD (r=0.384, P=0.002). GWE was positively correlated with GLS (r=0.519, P<0.001), and negatively correlated with MD (r=-0.482, P<0.001).

Conclusion

The myocardial work efficiency of patients with high normal blood pressure is still normal, while that of patients with hypertension is damaged and the energy loss is increased. Quantitative evaluation of myocardial work by left ventricular PSL may provide more valuable information for the evaluation of cardiac function in patients with high normal blood pressure and hypertension.

图1 超声心动图心肌做功参数图像。图a为正常血压受试者;图b为高值血压受试者;图c为高血压受试者注:GLS为整体长轴应变;GWI为整体做功指数;GCW为整体有效做功;GWW为整体无效做功;GWE为整体做功效率;BP为血压
表1 3组受试者一般资料比较(
xˉ
±s
表 2 3组受试者常规超声心动图参数比较(
xˉ
±s
表3 3组受试者左心室机械力学及心肌做功参数比较
表4 心肌做功参数重复性检验结果
1
Kachur S, Morera R, De Schutter A, et al. Cardiovascular risk in patients with prehypertension and the metabolic syndrome[J]. Curr Hypertens Rep, 2018, 20(2): 15.
2
Hiemstra YL, van der Bijl P, El Mahdiui M, et al. Myocardial work in nonobstructive hypertrophic cardiomyopathy: implications for outcome[J]. J Am Soc Echocardiogr, 2021, 34(2): 201.
3
Manganaro R, Marchetta S, Dulgheru R, et al. Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study[J]. Eur Heart J Cardiovasc Imaging, 2019, 20(5): 582-590.
4
中国高血压防治指南修订委员会, 高血压联盟(中国, 中华医学会心血管病学分会, 等. 中国高血压防治指南(2018年修订版)[J]. 中国心血管杂志, 2019, 24(1): 24-56.
5
Lang RM, Badano LP, Mor-Avi V, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging[J]. J Am Soc Echocardiogr, 2015, 28(1): 1-39.e14.
6
Edwards N, Scalia GM, Shiino K, et al. Global myocardial work is superior to global longitudinal strain to predict significant coronary artery disease in patients with normal left ventricular function and wall motion[J]. J Am Soc Echocardiogr, 2019, 32(8): 947-957.
7
Galli E, Leclercq C, Hubert A, et al. Role of myocardial constructive work in the identification of responders to CRT[J]. Eur Heart J Cardiovasc Imaging, 2018, 19(9): 1010-1018.
8
姚丙南, 仇萍, 王玉芳, 等. 分层应变技术对高血压前期患者左心室纵向收缩功能的评价[J]. 中国心血管杂志, 2017, 22(6): 418-422.
9
Chan J, Edwards N, Khandheria BK, et al. A new approach to assess myocardial work by non-invasive left ventricular pressure-strain relations in hypertension and dilated cardiomyopathy[J]. Eur Heart J Cardiovasc Imaging, 2019, 20(1): 31-39.
10
谷春红, 魏常华, 袁建军, 等. 纵向应变及应变达峰时间离散度评价原发性高血压患者左心室纵向收缩功能的应用价值[J]. 中华超声影像学杂志, 2018, 27(6): 473-478.
11
孔令云, 高霞, 丁雪晏, 等. 二维斑点追踪成像评价甲状腺功能减退症对左心室机械形变及其异质性的影响[J]. 中华超声影像学杂志, 2018, 27(4): 282-287.
[1] 李晓妮, 卫青, 孟庆龙, 牛丽莉, 田月, 吴伟春, 朱振辉, 王浩. 超声心动图在孤立性左心室心尖发育不良疾病中的应用价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 937-942.
[2] 陈慧, 姚静, 张宁, 刘磊, 马秀玲, 王小贤, 方爱娟, 管静静. 超声心动图在多发性骨髓瘤心脏淀粉样变中的诊断价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 943-949.
[3] 戴飞, 赵博文, 潘美, 彭晓慧, 陈冉, 田园诗, 狄敏. 胎儿心脏超声定量多参数对主动脉缩窄胎儿心脏结构及功能的诊断价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 950-958.
[4] 陈芬, 葛贝贝, 王小贤, 李明霞, 徐芳, 史坚, 郭冠军, 方爱娟, 史中青, 戚占如, 陈慧, 姚静. 左束支传导阻滞性心肌病心脏电-机械重构的实验研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 978-985.
[5] 王益佳, 周青, 曹省, 袁芳洁, 周妍, 张梅. 中国经胸超声心动图检查存图及报告质控现状分析[J/OL]. 中华医学超声杂志(电子版), 2024, 21(07): 657-663.
[6] 莫莹, 李文秀, 李刚, 王霄芳, 王强, 丁文虹. 超声心动图在三尖瓣下移畸形中的临床应用价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(07): 702-708.
[7] 王秋莲, 张莹, 李春敏, 徐树明, 张玉奇. 胎儿主动脉弓部梗阻伴发复杂心内畸形的产前超声诊断及漏误诊分析[J/OL]. 中华医学超声杂志(电子版), 2024, 21(07): 718-725.
[8] 曹雨欣, 毛卓君, 梁嘉赫, 伊江浦, 张泽凯, 马文帅, 陈云涛, 李晓倩, 张宇新, 曹铁生, 袁丽君. 3D打印心脏模型在模拟左心耳封堵术临床教学中的应用价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 602-607.
[9] 周容, 张亚萍, 廖宇, 程晓萍, 管玉龙, 潘广玉, 闫杰, 王贤芝, 苟中山, 潘登科, 李巅远. 超声在基因编辑猪-猴异种并联式心脏移植术中的应用价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 617-623.
[10] 夏靖涵, 林凤娇, 王胰, 丁戈琦, 张清凤, 张红梅, 谢盛华, 李明星, 尹立雪, 李文华. 二尖瓣空间变化联合左心房应变对肥厚型心肌病合并左心室流出道梗阻的预测价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 585-592.
[11] 王岚, 徐斌胜, 谢乐. 肥厚型心肌病的经胸超声心动图诊断与心电图表现特征[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 593-596.
[12] 孔莹, 惠品晶, 丁亚芳, 周炳元. 基于对比增强经颅多普勒的多模式超声评估卵圆孔未闭相关右向左分流的临床意义[J/OL]. 中华医学超声杂志(电子版), 2024, 21(04): 345-351.
[13] 卢天祺, 张巍, 周康, 毕士玉, 张羽, 杨秀华. 血流向量成像技术在不同Child-Pugh分级乙肝患者左心功能评价中的价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(04): 352-360.
[14] 陈嘉婷, 杜美君, 石冰, 黄汉尧. 母体系统性疾病对新生儿唇腭裂发生的影响[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(04): 262-268.
[15] 刘国龙, 王鹏, 谭超, 杨辉, 彭菊红. 神经外科机器人辅助双通道颅内血肿清除术治疗高血压性脑出血[J/OL]. 中华脑科疾病与康复杂志(电子版), 2024, 14(04): 254-256.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?