分析正常妊娠11~13⁺⁶周胎儿侧脑室脉络丛相关参数及其价值。

选取2017年1月至2021年1月在安徽医科大学第二附属医院超声诊断科行早孕期胎儿结构筛查的正常胎儿277例（妊娠11~13⁺⁶周），测量胎儿双侧侧脑室脉络丛长径、面积及大脑镰长度（CF-L），侧脑室脉络丛长径、面积，采用配对t检验分析左、右侧有无差异；侧脑室脉络丛平均长径（CP-L）、侧脑室脉络丛总面积（CP-A）、CP-L/CF-L与头臀长（CRL）的相关性采用Pearson相关性分析；以CRL作为自变量，CP-L、CP-A、CP-L/CF-L作为因变量，应用简单线性回归模型探索分析变量之间的关系，并建立CRL与相关参数测量值的线性回归方程；同时分析2017年1月至2022年3月在安徽医科大学第二附属医院超声诊断科行早孕期胎儿结构筛查发现的侧脑室脉络丛异常的11例胎儿（妊娠11~13⁺⁶周）的侧脑室脉络丛参数。

正常妊娠11~13⁺⁶周胎儿左侧与右侧侧脑室脉络丛长径、面积差异均无统计学意义（P均＞0.05）。CP-L与CRL呈线性正相关（r=0.681，P＜0.001），线性回归方程为：CP-L=0.134×CRL＋0.577；CP-A与CRL呈线性正相关（r=0.736，P＜0.001），线性回归方程为：CP-A=0.251×CRL-0.267；CP-L/CF-L与CRL呈线性负相关（r=-0.514，P＜0.001），线性回归方程为：CP-L/CF-L=-0.047×CRL＋1.011。早孕期侧脑室脉络丛异常者共11例，其中3例为双侧侧脑室脉络丛融合，1例为无侧脑室脉络丛，1例为侧脑室脉络丛不对称，另6例为侧脑室脉络丛小。

妊娠11~13⁺⁶周时，CP-L、CP-A、CP-L/CF-L与CRL呈线性相关，为侧脑室脉络丛检查提供一个可参考范围，具有一定的临床意义。

To study the parameters of the choroid plexus of the lateral ventricle in normal fetuses during 11 to 13⁺⁶ weeks of gestation and to analyze their clinical value.

From January 2017 to January 2021, 277 normal fetuses (during 11 to 13⁺⁶ weeks of gestation) who underwent fetal structure screening at the Second Affiliated Hospital of Anhui Medical University were selected to measure the length and area of bilateral ventricular choroid plexus and the length of the cerebral falx (CF-L). The length and area of the choroid plexus of bilateral ventricles were analyzed by paired t test. Pearson correlation analysis was performed to determine the correlation between the mean length of the choroid plexus of lateral ventricle (CP-L), the total area of the choroid plexus of lateral ventricle (CP-A), CP-L/CF-L ratio, and crown-rump length (CRL). Using CRL as the independent variable and CP-L, CP-A, and CP-L/CF-L ratio as dependent variables, a simple linear regression model was used to explore the relationship between the variables, and linear regression equations between CRL and the values of related parameters were established. Meanwhile, the parameters of 11 fetuses with abnormal choroid plexus of the lateral ventricle were analyzed, who underwent fetal structure screening at the Second Affiliated Hospital of Anhui Medical University during 11 to 13⁺⁶ weeks of gestation from January 2017 to March 2022.

There were no statistically significant differences in the length and area of the choroid plexus between the left and right lateral ventricles in normal fetuses during 11 to 13⁺⁶ weeks of gestation (P＞0.05). The linear regression equation of CP-L and CRL was: CP-L=0.134×CRL＋0.577 (r=0.681, P＜0.001), showing a positive linear correlation. The linear regression equation of CP-A and CRL was: CP-A=0.251×CRL-0.267 (r=0.736, P＜0.001), showing a positive linear correlation. The linear regression equation of CP-L/CF-L ratio and CRL was: CP-L/CF-L ratio=-0.047×CRL＋1.011 (r=-0.514, P＜0.001), showing a linear negative correlation. There were 11 cases of abnormal lateral ventricular choroid plexus in early pregnancy, including 3 cases of bilateral choroid plexus fusion, 1 case of absence of lateral ventricular choroid plexus, 1 case of asymmetric lateral ventricular choroid plexus, and 6 cases of small lateral ventricular choroid plexus.

CP-L, CP-A, and CP-L/ CF-L are linearly correlated with CRL during 11 to 13⁺⁶ weeks of gestation, which provides a reference range for the examination of the choroid plexus of the lateral ventricle and has appreciated clinical significance.