切换至 "中华医学电子期刊资源库"

中华医学超声杂志(电子版) ›› 2022, Vol. 19 ›› Issue (01) : 23 -30. doi: 10.3877/cma.j.issn.1672-6448.2022.01.005

妇产科超声影像学

产前部分上臂容积测量与新生儿出生体质量的相关性
张卿1, 吴桂花1,(), 朱国燕1   
  1. 1. 215128 江苏苏州,苏州市吴中人民医院超声科
  • 收稿日期:2020-04-22 出版日期:2022-01-01
  • 通信作者: 吴桂花

Correlation between prenatal fractional upper arm volume and neonatal birth weight

Qing Zhang1, Guihua Wu1,(), Guoyan Zhu1   

  1. 1. Department of Ultrasonography, Suzhou Wuzhong People's Hospital, Suzhou 125128, China
  • Received:2020-04-22 Published:2022-01-01
  • Corresponding author: Guihua Wu
引用本文:

张卿, 吴桂花, 朱国燕. 产前部分上臂容积测量与新生儿出生体质量的相关性[J/OL]. 中华医学超声杂志(电子版), 2022, 19(01): 23-30.

Qing Zhang, Guihua Wu, Guoyan Zhu. Correlation between prenatal fractional upper arm volume and neonatal birth weight[J/OL]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2022, 19(01): 23-30.

目的

探讨三维超声5D Limb技术测量正常孕晚期临产前7 d内胎儿部分上臂容积(AVol)在新生儿估算出生体质量(EFW)中的应用价值。

方法

选取2018年7月至2019年6月期间在苏州市吴中人民医院超声科进行产检的临产前7 d内的115例胎儿作为研究对象,运用二维、三维超声技术为孕妇产检,并记录相关测量值,主要包括双顶径、股骨长度、头围、腹围、AVol。采用单因素和多因素线性回归分析各参数与新生儿BW之间的相关性,并建立回归方程产生新的BW估算公式。以新生儿BW为金标准,Hadlock经典公式为对照,运用χ2检验比较Hadlock经典公式与新公式的估算符合率(绝对误差和相对误差)的差异。再将胎儿按照BW分为低BW组、正常BW组和巨大儿组,运用配对t检验比较2种公式估算3组胎儿BW的相对误差(系统误差±随机误差)的差异。

结果

单因素相关分析显示,BW与双顶径、头围、腹围、股骨长度、AVol均具有相关性(r=0.477、0.515、0.506、0.404、0.827,P均<0.001);多因素回归分析显示,腹围、AVol为新生儿BW估算的独立影响因素(P=0.007、<0.001);基于双顶径、头围、腹围、股骨长度、AVol构建回归方程EFW(AVol)=-2470.985+56.547×双顶径+33.225×头围+50.142×腹围+169.806×股骨+47.203×AVol。EFW(AVol)公式估算BW的绝对误差符合率和相对误差符合率均高于Hadlock经典公式(65.2% vs 48.7%;84.3% vs 64.3%),差异具有统计学意义(P=0.011、<0.001)。EFW(AVol)公式和Hadlock经典公式估算低BW组、正常BW组和巨大儿组胎儿BW的相对误差分别为(19.5%±7.2% vs 44.8%±29.6%)、(5.5%±4.3% vs 7.8%±5.5%)、(5.3%±3.4% vs 8.5%±4.5%),2种公式对正常BW组胎儿BW估算的相对误差比较,差异具有统计学意义(P<0.001)。

结论

AVol与BW相关性显著,可作为新参数应用于估算新生儿BW的临床实践中。

Objective

To explore the application value of fetal fractional upper arm volume (AVol) measured by three-dimensional ultrasound 5D Limb technique within 7 days before delivery in the normal third trimester of pregnancy in neonatal birth weight (BW) estimation.

Methods

From July 2018 to June 2019, 115 fetuses within 7 days before delivery at the Ultrasound Department of Wuzhong People's Hospital in Suzhou City were selected as the research subjects. Two-dimensional and three-dimensional ultrasound technology was used for maternity examination. The measured values mainly included double parietal diameter (BPD), femoral length (FL), head circumference (HC), abdominal circumference (AC), and AVol. The correlations between each parameter and newborn BW were analyzed and a multi-factor linear regression equation was established to generate a new weight estimation formula. With BW as the gold standard and Hadlock classic formula as a control, the Chi-square test was used to analyze the absolute error and relative error coincidence rate of the new formula. Then, the fetuses were divided into a low BW group, a normal BW group, and a macrosomia group according to BW. Paired t-test was used to estimate the systematic and random errors of BW of different groups of fetuses.

Results

BW had significant correlations with BPD, HC, AC, FL, and AVol (r=0.477, P<0.001; r=0.515, P<0.001; r=0.506, P<0.001; r=0.404, P<0.001; r=0.827, P<0.001). The regression equation generated was EFW(AVol)=-2470.985+56.547×BPD+33.225×HC+50.142×AC+169.806×FL+47.203×AVol. The new formula had significantly higher absolute and relative error compliance rates for BW estimation than the Hadlock classical formula (65.2% vs 48.7%, P=0.011; 84.3% vs 64.3%, P<0.001). The relative errors of the new formula and the Hadlock classical formula for fetal BW estimation in the low BW group, normal BW group, and macrosomia group were (19.5%±7.2%) vs (44.8%±29.6%), (5.5%±4.3%) vs (7.8%±5.5%), and (5.3%±3.4%) vs (8.5%±4.4%), respectively, with statistically significant differences between the two formulas (P<0.001).

Conclusion

AVol has a significant correlation with BW, and can be used as a new parameter for estimating neonatal BW in clinical practice.

图1 正常出生体质量儿上臂三维容积超声扫描图。图a为肱骨长轴切面,以肱骨中心的50%肱骨长度作5个等距横截面;图b为肱骨中心所在的上臂横截面
图2 巨大儿部分上臂容积(AVol)容积图像。分别描记胎儿上臂5个横截面边界,软件自动计算每个横截面面积,最后得出50%肱骨长度的肢体容积为AVol。图a~e是以肱骨中心50%长度作的5个等距横截面图。图f是由5个等距横截面及50%肱骨长度计算所得的AVol图像
图3 正常出生体质量儿部分上臂容积(AVol)容积图像。分别描记胎儿上臂5个横截面边界,软件自动计算每个横截面面积,最后得出50%肱骨长度的肢体容积为AVol。图a~e是以肱骨中心50%长度作的5个等距横截面图。图f是由5个等距横截面及50%肱骨长度计算所得的AVol图像
图4 操作者通过三维超声2次测量同一部分上臂容积的Bland-Altman图
图5 胎儿部分上臂容积与出生体质量关系散点图
表1 产前部分上臂容积估算新生儿出生体质量的多因素线性回归分析
表2 2种新生儿出生体质量估算公式的估算符合率比较[例(%)]
表3 2种公式估算不同BW组胎儿体质量的相对误差比较(
xˉ
±s
1
World Health O, United Nations Children's F. Low birthweight: country, regional and global estimates [M]. Geneva: World Health Organization, 2004: 8.
2
Simeone S, Marchi L, Canarutto R, et al. Doppler velocimetry and adverse outcome in labor induction for late IUGR [J]. J Matern Fetal Neonatal Med, 2017, 30(3): 323-328.
3
张金华, 伍啸青, 牛建军, 等. 厦门市巨大儿发生现状及影响因素研究 [J]. 国外医学: 医学地理分册, 2017, 38(4): 325-327.
4
Macrosomia: ACOG Practice Bulletin, Number 216 [J]. Obstet Gynecol, 2020, 135(1): e18-e35.
5
Melamed N, Yogev Y, Meizner I, et al. Sonographic fetal weight estimation: which model should be used? [J]. J Ultrasound Med, 2009, 28(5): 617-629.
6
Moyer-Mileur LJ, Slater H, Thomson JA, et al. Newborn adiposity measured by plethysmography is not predicted by late gestation two-dimensional ultrasound measures of fetal growth [J]. J Nutr, 2009, 139(9): 1772-1778.
7
Deter R, Nazar R, Milner L. Modified neonatal growth assessment score: a multivariate approach to the detection of intrauterine growth retardation in the neonate [J]. Ultrasound Obstet Gynecol, 1995, 6(6): 400-410.
8
Lee W, Balasubramaniam M, Deter R, et al. Fractional limb volume-a soft tissue parameter of fetal body composition: validation, technical considerations and normal ranges during pregnancy [J]. Ultrasound Obstet Gynecol, 2009, 33(4): 427-440.
9
Khoury FR, Stetzer B, Myers SA, et al. Comparison of estimated fetal weights using volume and 2-dimensional sonography and their relationship to neonatal markers of fat [J]. J Ultrasound Med, 2009, 28(3): 309-315.
10
Pagani G, Palai N, Zatti S, et al. Fetal weight estimation in gestational diabetic pregnancies: comparison between conventional and three-dimensional fractional thigh volume methods using gestation-adjusted projection [J]. Ultrasound Obstet Gynecol, 2014, 43(1): 72-76.
11
Hadlock F, Shah Y, Kanon D, et al. Fetal crown-rump length: reevaluation of relation to menstrual age (5-18 weeks) with high-resolution real-time US [J]. Radiology, 1992, 182(2): 501-505.
12
中国医师协会超声医师分会. 中国产科超声检查指南 [M]. 北京: 人民卫生出版社, 2019.
13
Hur H, Kim YH, Cho HY, et al. Feasibility of three-dimensional reconstruction and automated measurement of fetal long bones using 5D Long Bone [J]. Obstet Gynecol Sci, 2015, 58(4): 268-276.
14
Mgbafulu CC, Ajah LO, Umeora OUJ, et al. Estimation of fetal weight: a comparison of clinical and sonographic methods [J]. J Obstet Gynaecol, 2019, 39(5): 639-646.
15
Balsyte D, Schäffer L, Burkhardt T, et al. Sonographic prediction of macrosomia cannot be improved by combination with pregnancy-specific characteristics [J]. Ultrasound Obstet Gynecol, 2009, 33(4): 453-458.
16
Liao S, Wang Y, Xiao S, et al. A new model for birth weight prediction using 2- and 3-dimensional ultrasonography by principal component analysis: a Chinese population study [J]. J Ultrasound Med, 2018, 37(11): 2553-2563.
17
Landon MB, Mintz MC, Gabbe SG. Sonographic evaluation of fetal abdominal growth: predictor of the large-for-gestational-age infant in pregnancies complicated by diabetes mellitus [J]. Am J Obstet Gynecol, 1989, 160(1): 115-121.
18
Cromi A, Ghezzi F, Di Naro E, et al. Large cross‐sectional area of the umbilical cord as a predictor of fetal macrosomia [J]. Ultrasound Obstet Gynecol, 2007, 30(6): 861-866.
19
Mongelli M, Chew S, Yuxin N, et al. Third‐trimester ultrasound dating algorithms derived from pregnancies conceived with artificial reproductive techniques [J]. Ultrasound Obstet Gynecol, 2005, 26(2): 129-131.
20
Kayem G, Grangé G, Bréart G, et al. Comparison of fundal height measurement and sonographically measured fetal abdominal circumference in the prediction of high and low birth weight at term [J]. Ultrasound Obstet Gynecol, 2009, 34(5): 566-571.
21
Xu Y, Lek N, Cheung YB, et al. Unconditional and conditional standards for fetal abdominal circumference and estimated fetal weight in an ethnic Chinese population: a birth cohort study [J]. BMC Pregnancy Childbirth, 2015, 15(1): 1-11.
22
Johnsen SL, Wilsgaard T, Rasmussen S, et al. Longitudinal reference charts for growth of the fetal head, abdomen and femur [J]. Eur J Obstet Gynecol Reprod Biol, 2006, 127(2): 172-185.
23
Mohsen L, Amin MF. 3D and 2D ultrasound-based fetal weight estimation: a single center experience [J]. J Matern Fetal Neonatal Med, 2017, 30(7): 818-825.
24
Lee W, Mack L, Sangi-haghpeykar H, et al. Fetal weight estimation using automated fractional limb volume with 2-dimensional size parameters [J]. J Ultrasound Med, 2020, 39(7): 1317-1324.
25
Simcox L, Myers J, Cole T, et al. Fractional fetal thigh volume in the prediction of normal and abnormal fetal growth during the third trimester of pregnancy [J]. Am J Obstet Gynecol, 2017, 217(4): 453.e1-453.e12.
[1] 章建全, 程杰, 陈红琼, 闫磊. 采用ACR-TIRADS评估甲状腺消融区的调查研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 966-971.
[2] 罗辉, 方晔. 品管圈在提高甲状腺结节细针穿刺检出率中的应用[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 972-977.
[3] 杨忠, 时敬业, 邓学东, 姜纬, 殷林亮, 潘琦, 梁泓, 马建芳, 王珍奇, 张俊, 董姗姗. 产前超声在胎儿22q11.2 微缺失综合征中的应用价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(09): 852-858.
[4] 孙佳丽, 金琳, 沈崔琴, 陈晴晴, 林艳萍, 李朝军, 徐栋. 机器人辅助超声引导下经皮穿刺的体外实验研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(09): 884-889.
[5] 史学兵, 谢迎东, 谢霓, 徐超丽, 杨斌, 孙帼. 声辐射力弹性成像对不可切除肝细胞癌门静脉癌栓患者放射治疗效果的评价[J/OL]. 中华医学超声杂志(电子版), 2024, 21(08): 778-784.
[6] 李洋, 蔡金玉, 党晓智, 常婉英, 巨艳, 高毅, 宋宏萍. 基于深度学习的乳腺超声应变弹性图像生成模型的应用研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 563-570.
[7] 洪玮, 叶细容, 刘枝红, 杨银凤, 吕志红. 超声影像组学联合临床病理特征预测乳腺癌新辅助化疗完全病理缓解的价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 571-579.
[8] 项文静, 徐燕, 茹彤, 郑明明, 顾燕, 戴晨燕, 朱湘玉, 严陈晨. 神经学超声检查在产前诊断胼胝体异常中的应用价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(05): 470-476.
[9] 胡可, 鲁蓉. 基于多参数超声特征的中老年女性压力性尿失禁诊断模型研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(05): 477-483.
[10] 张妍, 原韶玲, 史泽洪, 郭馨阳, 牛菁华. 小肾肿瘤超声漏诊原因分析新思路[J/OL]. 中华医学超声杂志(电子版), 2024, 21(05): 500-504.
[11] 席芬, 张培培, 孝梦甦, 刘真真, 张一休, 张璟, 朱庆莉, 孟华. 乳腺错构瘤的临床与超声影像学特征分析[J/OL]. 中华医学超声杂志(电子版), 2024, 21(05): 505-510.
[12] 钱警语, 郑明明. 《2024意大利妇产科学会非侵入性和侵入性产前诊断指南》解读[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 486-492.
[13] 张琛, 秦鸣, 董娟, 陈玉龙. 超声检查对儿童肠扭转缺血性改变的诊断价值[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 565-568.
[14] 陈秀晓, 隋文倩, 王珉鑫, 吴圆圆. 腹股沟斜疝并腹腔游离体超声表现一例[J/OL]. 中华临床医师杂志(电子版), 2024, 18(05): 516-517.
[15] 张芳芳, 李军, 赵玉洁, 于彤, 宁春平. 侵袭性血管黏液瘤的影像学特征并文献复习[J/OL]. 中华诊断学电子杂志, 2024, 12(04): 254-259.
阅读次数
全文


摘要