切换至 "中华医学电子期刊资源库"

中华医学超声杂志(电子版) ›› 2016, Vol. 13 ›› Issue (05) : 378 -383. doi: 10.3877/cma.j.issn.1672-6448.2016.05.011

所属专题: 文献

腹部超声影像学

超声造影在肝包膜结核诊断中的应用价值
杨高怡1,(), 徐建平1, 张文智1, 于秀蕾1, 于天琢1, 闻波平1   
  1. 1. 310003 杭州,杭州市红十字会医院超声科
  • 收稿日期:2016-03-01 出版日期:2016-05-01
  • 通信作者: 杨高怡
  • 基金资助:
    杭州市卫生科技计划项目(2014A40)

Application value of contrast-enhanced ultrasound in the diagnosis of hepatic capsule tuberculosis

Gaoyi Yang1,(), Jianping Xu1, Wenzhi Zhang1, Xiulei Yu1, Tianzhuo Yu1, Boping Wen1   

  1. 1. Department of Ultrasound, Red Cross HospitaI of Hangzhou, Hangzhou 310003, China
  • Received:2016-03-01 Published:2016-05-01
  • Corresponding author: Gaoyi Yang
  • About author:
    Corresponding author: Yang Gaoyi, Email:
引用本文:

杨高怡, 徐建平, 张文智, 于秀蕾, 于天琢, 闻波平. 超声造影在肝包膜结核诊断中的应用价值[J/OL]. 中华医学超声杂志(电子版), 2016, 13(05): 378-383.

Gaoyi Yang, Jianping Xu, Wenzhi Zhang, Xiulei Yu, Tianzhuo Yu, Boping Wen. Application value of contrast-enhanced ultrasound in the diagnosis of hepatic capsule tuberculosis[J/OL]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2016, 13(05): 378-383.

目的

探讨肝包膜结核的超声造影表现特点。

方法

回顾性分析2008年12月至2015年10月杭州市红十字会医院经超声引导下穿刺活检或手术病理证实为肝包膜结核的患者共48例,对48例肝包膜结核患者的71个病灶进行常规超声及超声造影检查,分析其位置、形态、大小、回声和增强时相、强度及模式等特征。

结果

肝包膜结核常位于肝脏膈面包膜(54/71,76.1%),形态以梭形多见(59/71,83.1%),常呈混合回声(48/71,67.6%)。根据病灶与肝包膜的关系将肝包膜结核分为2种类型,Ⅰ型表现为病灶与肝实质接触处肝包膜连续性完整(37/71,52.1%),Ⅱ型表现为病灶与肝实质接触处肝包膜连续性中断(Ⅱa型,20/71,28.2%)或完全消失(Ⅱb型,14/71,19.7%)。超声造影示63个(88.7%)病灶表现为动脉期高增强,平均增强起始时间为(12.5±2.2)s(范围为9~17 s),达峰时间为(28.4±3.8)s(范围为22~35 s),门脉期及延迟期病灶呈等增强或低增强,有8个(11.3%)病灶表现为超声造影全程无增强。按峰值强度时病灶回声不同可分为4种表现:无增强(8/71,11.3%),环形增强(29/71,40.8%),不均匀增强(24/71,33.8%),均匀增强(10/71,14.1%)。本研究中不同类型的肝包膜结核超声造影表现差异有统计学意义(P<0.01)。

结论

肝包膜结核超声造影表现以环形增强及不均匀增强多见,超声造影可显示肝包膜结核的血流灌注情况,在肝包膜结核的诊断中具有重要参考价值。

Objective

To investigate the characteristics of contrast-enhanced ultrasound in hepatic capsule tuberculosis.

Methods

Forty-eight hepatic capsule tuberculosis patients who proved by ultrasound-guided needle biopsy or surgical pathology from Hangzhou Red Cross Hospital from Dec 2008 to Oct 2015 were retrospective analyzed. Totally 71 lesions of 48 hepatic capsule tuberculosis patients were examined by both routine and contrast-enhanced ultrasound to analyze their characteristics of location, shape, size, echo and enhanced phase, intensity and mode etc.

Results

Hepatic capsule tuberculosis was commonly displayed on hepatic diaphragmatic surface capsule (54/71, 76.1%) with fusiform shape (59/71, 83.1%) and hybrid echo (48/71, 67.6%) mostly. Hepatic capsule tuberculosis was divided into two types based on the relations between lesion and hepatic capsule. Type Ⅰ was performed to be the integrated continuity of hepatic capsule at the boundary of lesion and liver (37/71, 52.1%). Type Ⅱ was performed to be interrupted continuity of hepatic capsule at the boundary of lesion and liver (Type Ⅱa, 20 cases, 28.2%) or disappearance (TypeⅡb, 14 cases, 19.7%). Sixty-three lesions (88.7%) were performed to be hyper-enhanced in arterial phase by contrast-enhanced ultrasound. The average starting time of enhancement was (12.5±2.2) s (range 9-17 s). The average peak time was (28.4±3.8) s (range 22-35 s). Lesions in portal phase and delay phase were showed mid-enhanced or low-enhanced, and 8 cases (11.3%) were showed non-enhanced by contrast-enhanced ultrasound all the time. Lesion echo could be divided into 4 performances according to peak intensity: non-enhancement (8 cases, 11.3%), annular enhancement (29 cases, 40.8%), nonhomogeneous enhancement (24 cases, 33.8%) and homogeneous enhancement (10 cases, 14.1%). Differences between different results of hepatic capsule tuberculosis by contrast-enhanced ultrasound were significantly statistical (P<0.01).

Conclusions

Hepatic capsule tuberculosis is mostly performed to be annular enhancement and nonhomogeneous enhancement by contrast-enhanced ultrasound. Contrast-enhanced ultrasound can show the blood perfusion of hepatic capsule tuberculosis, which has important reference value in such diagnosis.

表1 肝包膜结核常规超声表现
图4 Ⅱb型肝包膜结核超声造影图。图4a示肝包膜区圆形低回声病灶(箭头),内可见"肝包膜贯穿征"(三角形箭头);图4b 示注射造影剂后16 s(动脉期),病灶所属肝段增强,呈三角形(三角形箭头);图4c 示注射造影剂后54 s(门脉期),肝段与周围肝组织等增强,病灶呈低增强;图4d 示注射造影剂后185 s(延迟期)病灶强度明显低于周围肝组织
表2 不同类型的肝包膜结核超声造影表现(个数)
[1]
Singh S, Jain P, Aggarwal G, et al. Primary hepatic tuberculosis: a rare but fatal clinical entity if undiagnosed [J]. Asian Pac J Trop Med, 2012, 5(6): 498-499.
[2]
Cao BS, Li XL, Li N, et al. The nodular form of hepatic tuberculosis: contrast-enhanced ultrasonographic findings with pathologic correlation [J]. J Ultrasound Med, 2010, 29(6): 881-888.
[3]
Yu RS, Zhang SZ, Wu JJ, et al. Imaging diagnosis of 12 patients with hepatic tuberculosis [J]. World J Gastroenterol, 2004, 10(11): 1639-1642.
[4]
陈灏珠, 林果为, 王吉耀. 实用内科学[M]. 14版. 北京: 人民卫生出版社, 2013: 594.
[5]
Sporea I, Martie A, Bota S, et al. Characterization of focal liver lesions using contrast-enhanced ultrasound as a first line method: a large monocentric experience [J]. J Gastrointestin Liver Dis, 2014, 23(1): 57-63.
[6]
Kim TK, Jang HJ. Contrast-enhanced ultrasound in the diagnosis of nodules in liver cirrhosis [J]. World J Gastroenterol, 2014, 20(13): 3590-3596.
[7]
Ryu SW, Bok GH, Jang JY, et al . Clinically useful diagnostic tool of contrast enhanced ultrasonography for focal liver masses: comparison to computed tomography and magnetic resonance imaging [J].Gut Liver, 2014, 8(3): 292-297.
[8]
Kumar V, Pandey D. Isolated hepatosplenic tuberculosis [J]. Hepatobiliary Pancreat Dis Int, 2008, 7(3): 328-330.
[9]
张帆, 张雪林, 邱士军, 等. CT对肝结核的诊断价值[J]. 中华放射学杂志, 2006, 40(6): 658-661
[10]
曹兵生, 张蕊, 黎晓林, 等. 肝结核超声动态造影表现及其病理基础[J]. 中国超声医学杂志, 2008, 24(7): 657-660.
[11]
Itai Y, Matsui O. Blood flow and liver imaging [J]. Radiology, 1997, 202(2): 306-314.
[12]
罗天友, 史斌, 李咏梅, 等. 肝脏螺旋CT动态增强扫描时肝动脉期肝实质一过性异常强化的研究[J]. 中华放射学杂志, 2003, 37(3): 258-263.
[13]
Meloni MF, Andreano A, Laeseke PF, et al. contrast-enhanced ultrasonographic findings in a brucellar hepatic abscess [J]. J Ultrasound Med, 2008, 27(10): 1511-1515.
[14]
Kothari H, Keshava S, Vatsyayan R, et al. Role of tissue factor in Mycobacterium tuberculosis-induced inflammation and disease pathogenesis [J]. PLoS One, 2014, 9(12): e114141.
[15]
丁红, 王文平, 黄备建, 等.肝脏实质性占位病灶的超声造影检测[J/CD]. 中华医学超声杂志:电子版, 2007, 4(1): 28-31.
[1] 章建全, 程杰, 陈红琼, 闫磊. 采用ACR-TIRADS评估甲状腺消融区的调查研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 966-971.
[2] 罗辉, 方晔. 品管圈在提高甲状腺结节细针穿刺检出率中的应用[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 972-977.
[3] 杨忠, 时敬业, 邓学东, 姜纬, 殷林亮, 潘琦, 梁泓, 马建芳, 王珍奇, 张俊, 董姗姗. 产前超声在胎儿22q11.2 微缺失综合征中的应用价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(09): 852-858.
[4] 孙佳丽, 金琳, 沈崔琴, 陈晴晴, 林艳萍, 李朝军, 徐栋. 机器人辅助超声引导下经皮穿刺的体外实验研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(09): 884-889.
[5] 宋勇, 李东炫, 王翔, 李锐. 基于数据挖掘法分析3 种超声造影剂不良反应信号[J/OL]. 中华医学超声杂志(电子版), 2024, 21(09): 890-898.
[6] 史学兵, 谢迎东, 谢霓, 徐超丽, 杨斌, 孙帼. 声辐射力弹性成像对不可切除肝细胞癌门静脉癌栓患者放射治疗效果的评价[J/OL]. 中华医学超声杂志(电子版), 2024, 21(08): 778-784.
[7] 李洋, 蔡金玉, 党晓智, 常婉英, 巨艳, 高毅, 宋宏萍. 基于深度学习的乳腺超声应变弹性图像生成模型的应用研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 563-570.
[8] 洪玮, 叶细容, 刘枝红, 杨银凤, 吕志红. 超声影像组学联合临床病理特征预测乳腺癌新辅助化疗完全病理缓解的价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 571-579.
[9] 项文静, 徐燕, 茹彤, 郑明明, 顾燕, 戴晨燕, 朱湘玉, 严陈晨. 神经学超声检查在产前诊断胼胝体异常中的应用价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(05): 470-476.
[10] 胡可, 鲁蓉. 基于多参数超声特征的中老年女性压力性尿失禁诊断模型研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(05): 477-483.
[11] 张妍, 原韶玲, 史泽洪, 郭馨阳, 牛菁华. 小肾肿瘤超声漏诊原因分析新思路[J/OL]. 中华医学超声杂志(电子版), 2024, 21(05): 500-504.
[12] 席芬, 张培培, 孝梦甦, 刘真真, 张一休, 张璟, 朱庆莉, 孟华. 乳腺错构瘤的临床与超声影像学特征分析[J/OL]. 中华医学超声杂志(电子版), 2024, 21(05): 505-510.
[13] 陈意志. 核磁共振钆造影剂导致的肾源性系统性纤维化[J/OL]. 中华肾病研究电子杂志, 2024, 13(06): 358-358.
[14] 张琛, 秦鸣, 董娟, 陈玉龙. 超声检查对儿童肠扭转缺血性改变的诊断价值[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 565-568.
[15] 马豆豆, 丁艳, 古今, 王丽芳, 石连杰. 以发热为首发表现的强直性脊柱炎合并潜伏性结核感染一例[J/OL]. 中华临床医师杂志(电子版), 2024, 18(08): 791-794.
阅读次数
全文


摘要