切换至 "中华医学电子期刊资源库"

中华医学超声杂志(电子版) ›› 2025, Vol. 22 ›› Issue (07) : 614 -619. doi: 10.3877/cma.j.issn.1672-6448.2025.07.005

浅表器官超声影像学

甲状腺转移癌多模态超声及临床特征
武晓凤, 谷杨, 黄莹, 张丽红, 孙梦瑶, 胡梦裳, 王洁, 房钰婷, 金晨阳, 王葛超, 董凤林()   
  1. 215031 苏州大学附属第一医院超声医学科
  • 收稿日期:2025-05-15 出版日期:2025-07-01
  • 通信作者: 董凤林
  • 基金资助:
    苏州大学附属第一医院博习临床研究项目(BXLC002); 苏州大学附属第一医院自然科学基金博习培育计划(BXQN2024001)

Multimodal ultrasound and clinical characteristics of thyroid metastases: a decade-long retrospective analysis

Xiaofeng Wu, Yang Gu, Ying Huang, Lihong Zhang, Mengyao Sun, Mengshang Hu, Jie Wang, Yuting Fang, Chenyang Jin, Gechao Wang, Fenglin Dong()   

  1. Department of Ultrasound, the First Affiliated Hospital of Soochow University, Suzhou 215031, China
  • Received:2025-05-15 Published:2025-07-01
  • Corresponding author: Fenglin Dong
引用本文:

武晓凤, 谷杨, 黄莹, 张丽红, 孙梦瑶, 胡梦裳, 王洁, 房钰婷, 金晨阳, 王葛超, 董凤林. 甲状腺转移癌多模态超声及临床特征[J/OL]. 中华医学超声杂志(电子版), 2025, 22(07): 614-619.

Xiaofeng Wu, Yang Gu, Ying Huang, Lihong Zhang, Mengyao Sun, Mengshang Hu, Jie Wang, Yuting Fang, Chenyang Jin, Gechao Wang, Fenglin Dong. Multimodal ultrasound and clinical characteristics of thyroid metastases: a decade-long retrospective analysis[J/OL]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2025, 22(07): 614-619.

目的

分析甲状腺转移癌(TM)常规超声及超声造影(CEUS)特征,提升超声医师对TM的影像学识别能力与临床诊断水平。

方法

回顾性收集2015年1月至2024年12月期间苏州大学附属第一医院经病理确诊的TM患者17例,记录其临床特征,并由2名医师对超声图像进行判读,分析TM的常规超声和CEUS特征。

结果

本研究共纳入17例经病理证实的TM患者,原发肿瘤来源依次为:肺癌及食管癌各5例(29.41%),喉癌3例(17.65%),鼻咽癌、胰腺癌、胸部软骨肉瘤、乳腺癌各1例(5.88%)。临床表现方面,41.18%(7/17)的患者短期内病灶明显增大、23.53%(4/17)出现呼吸困难、58.82%(10/17)出现声音嘶哑、47.06%(8/17)伴吞咽哽噎。常规超声显示,病灶累及单侧叶者14例(82.35%),累及双侧叶者3例(17.65%);病灶以结节型(88.24%,15/17)、低回声(82.35%,14/17)、边缘模糊或不规则或向甲状腺外延伸(88.24%,15/17)为主,弥漫型2例(11.76%)。47.06%(8/17)为囊实性;23.53%(4/17)可见粗大钙化,35.29%(6/17)可见微钙化。CEUS图像特征:CEUS资料完整的10例患者中,8例(80.00%)表现为不均匀增强,8例(80.00%)可见灌注缺损区;增强强度方面,呈低增强者与等/高增强者各占50.00%。

结论

TM在常规超声与CEUS中表现出一定影像学特征,结合患者的原发病史及临床症状,应用多模态超声有助于提高对TM的早期识别与准确诊断。

Objective

To investigate the utility of conventional ultrasound and contrast-enhanced ultrasound (CEUS) in the diagnosis of thyroid metastases (TM), aiming to enhance the imaging-based recognition and clinical diagnostic accuracy among ultrasound physicians.

Methods

This retrospective study analyzed 17 cases of TM confirmed by histopathological examination at the First Affiliated Hospital of Soochow University from January 2015 to December 2024. Clinical characteristics were systematically documented, and ultrasound images were independently reviewed by two experienced radiologists. The study primarily assessed conventional and contrast-enhanced ultrasonographic features of TM.

Results

Seventeen patients with pathologically confirmed TM were included. The primary tumors originated from lung cancer and esophageal cancer in 5 cases each (29.41%), laryngeal cancer in 3 (17.65%), and nasopharyngeal carcinoma, pancreatic cancer, thoracic chondrosarcoma, and breast cancer in 1 case each (5.88%). Clinically, rapid lesion enlargement within a short interval was observed in 7 patients (41.18%), dyspnea in 4 (23.53%), hoarseness in 10 (58.82%), and dysphagia in 8 (47.06%). Conventional ultrasound revealed unilateral lobe involvement in 14 patients (82.35%) and bilateral involvement in 3 (17.65%). Most lesions were nodular (88.24%, 15/17), hypoechoic (82.35%, 14/17), and characterized by ill-defined or irregular margins or extrathyroidal extension (88.24%, 15/17); 2 cases (11.76%) presented with a diffuse pattern. Cystic-solid composition was detected in 8 cases (47.06%), coarse calcifications in 4 (23.53%), and microcalcifications in 6 (35.29%). Among the 10 patients with complete CEUS data, 8 (80.00%) exhibited heterogeneous enhancement and 8 (80.00%) demonstrated perfusion defects. Enhancement intensity was equally divided between low enhancement and iso-/hyperenhancement (50.00% each).

Conclusion

TM exhibit distinct conventional ultrasound and CEUS features. When integrated with clinical history, multimodal ultrasound evaluation significantly enhances early detection and diagnostic accuracy of TM.

表1 甲状腺转移癌超声检查表现
图1 患者男性,72岁,因“发现颈部肿胀1个月,疑似颈部脓肿拟行超声引导下置管引流”来诊。患者1年前于外院行喉部分切除术+暂时性气管切开术,术后病理:中分化鳞状细胞癌(分期T2N0M0)。图a、b、c分别为横切(左侧叶)、纵切(左侧叶)、横切(双侧叶+狭部)灰阶超声图像:甲状腺左侧叶内见低回声,大小约43 mm×29 mm,纵横比<1,边缘向甲状腺外延伸,其内可见无回声区,甲状腺右侧叶正常。图d:侧颈区可见肿大淋巴结,淋巴门回声消失。图e:超声造影呈不均匀等/高增强,内可见大片状无增强区。图f:CT显示甲状腺左侧叶占位。图g:病理染色结果为转移性鳞癌伴坏死(HE×40)
1
Calzolari F, Sartori PV, Talarico C, et al. Surgical treatment of intrathyroid metastases: preliminary results of a multicentric study [J]. Anticancer Res, 2008, 28(5B): 2885-2888.
2
Mirallie E, Rigaud J, Mathonnet M, et al. Management and prognosis of metastases to the thyroid gland [J]. J Am Coll Surg, 2005, 200(2): 203-207.
3
Nakhjavani MK, Gharib H, Goellner JR, et al. Metastasis to the thyroid gland. A report of 43 cases [J]. Cancer, 1997, 79(3): 574-578.
4
赵瑞娜, 张波, 姜玉新, 等. 甲状腺转移癌的超声征象 [J]. 协和医学杂志, 2014, 5(1): 17-21.
5
白玲, 杨涛, 唐英, 等. 甲状腺转移癌的超声影像表现 [J]. 军事医学科学院院刊, 2008, 32(4): 373-374.
6
朱媛, 王珍芳, 商静, 等. 甲状腺转移癌超声征象及超声引导下细针穿刺术活组织检查的价值 [J]. 中国超声医学杂志, 2024, 40(1): 103-106.
7
Zhou J, Yin L, Wei X, et al. 2020 Chinese guidelines for ultrasound malignancy risk stratification of thyroid nodules: the C-TIRADS [J]. Endocrine, 2020, 70(2): 256-279.
8
Adler DD, Carson PL, Rubin JM, et al. Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings [J]. Ultrasound Med Biol, 1990, 16(6): 553-559.
9
Baloch ZW, Asa SL, Barletta JA, et al. Overview of the 2022 who classification of thyroid neoplasms [J]. Endocr Pathol, 2022, 33(1): 27-63.
10
Papi G, Fadda G, Corsello SM, et al. Metastases to the thyroid gland: prevalence, clinicopathological aspects and prognosis: a 10‐year experience [J]. Clin Endocrinol (Oxf), 2007, 66(4): 565-571.
11
Cichoń S, Anielski R, Konturek A, et al. Metastases to the thyroid gland: seventeen cases operated on in a single clinical center [J]. Langenbecks Arch Surg, 2006, 391(6): 581-587.
12
Chen H, Nicol TL, Udelsman R. Clinically significant, isolated metastatic disease to the thyroid gland [J]. World J Surg, 1999, 23(2): 177-180, 181.
13
Hegerova L, Griebeler ML, Reynolds JP, et al. Metastasis to the thyroid gland: report of a large series from the Mayo Clinic [J]. Am J Clin Oncol, 2015, 38(4): 338-342.
14
Chung AY, Tran TB, Brumund KT, et al. Metastases to the thyroid: a review of the literature from the last decade [J]. Thyroid, 2012, 22(3): 258-268.
15
Lam K. Metastatic tumours of the thyroid gland: a study of 79 cases in Chineses patients [J]. Arch Pathol Lab Med, 1998, 122: 37-41.
16
刘春, 成雪晴, 何发伟, 等. 甲状腺转移癌的超声表现和临床特点研究 [J]. 中国超声医学杂志, 2021, 37(8): 941-944.
17
Tang Z, Gao L, Wang X, et al. Metastases to the thyroid gland: ultrasonographic findings and diagnostic value of fine-needle aspiration cytology [J]. Front Oncol, 2022, 12(3): 939965.
18
Yoon JH, Kim EK, Kwak JY, et al. Sonographic features and ultrasonography-guided fine-needle aspiration of metastases to the thyroid gland [J]. Ultrasonography, 2014, 33(1): 40-48.
19
Bible KC, Kebebew E, Brierley J, et al. 2021 American thyroid association guidelines for management of patients with anaplastic thyroid cancer [J]. Thyroid, 2021, 31(3): 337-386.
20
Zylka A, Dobruch-Sobczak K, Piotrzkowska-Wroblewska H, et al. The utility of contrast-enhanced ultrasound (CEUS) in assessing the risk of malignancy in thyroid nodules [J]. Cancers (Basel), 2024, 16(10): 1911.
21
Zhang C, Liu ZL, Wei ZH, et al. The value and sensitivity of contrast-enhanced ultrasonography combined with fine-needle aspiration biopsy in the diagnosis of thyroid nodules [J]. Sci Rep, 2024, 14(1): 29633.
22
赵玲, 商雷, 何岸柳, 等. 超声对原发性甲状腺淋巴瘤与甲状腺未分化癌的鉴别诊断 [J/OL]. 中华医学超声杂志(电子版), 2021, 18(1): 17-24.
[1] 江瑶, 蒋程, 余翔, 谭莹, 温昕, 温慧莹, 彭桂艳, 李胜利. 基于注意力机制改进的子宫解剖结构检测与分割多任务模型的性能评估[J/OL]. 中华医学超声杂志(电子版), 2025, 22(08): 703-710.
[2] 陈明朗, 许凯, 黄稚熙, 梁博诚, 贺杰, 黄海珊, 马微波, 谭莹, 邹志英, 刘晓棠, 彭桂艳, 陈家希, 钟晓红. MobileNetV4:面向产前超声的主动脉弓分支异常智能诊断研究[J/OL]. 中华医学超声杂志(电子版), 2025, 22(08): 711-720.
[3] 杨丽仙, 黄稚熙, 梁博诚, 欧阳淑媛, 陈明朗, 赵英丽, 马薇波, 缪敬, 王磊, 袁鹰. 基于产前时序超声数据的新生儿出生体重智能预测[J/OL]. 中华医学超声杂志(电子版), 2025, 22(08): 721-732.
[4] 康林立, 陈璐, 张天歌, 刘勤, 汪龙霞. 妊娠期卵巢子宫内膜异位囊肿蜕膜化的临床及超声影像学特征[J/OL]. 中华医学超声杂志(电子版), 2025, 22(08): 733-739.
[5] 罗兵, 董凤群, 牛艺臻, 王锟, 程志华, 刘宏强. 胎儿超声心动图在单纯性肺动脉瓣狭窄及预后评估中的价值[J/OL]. 中华医学超声杂志(电子版), 2025, 22(08): 740-747.
[6] 陆溧玲, 杨秀珍, 徐彬, 赵镭, 钱晶晶, 李晓英, 王彪, 叶菁菁. 婴幼儿陈旧性卵巢囊肿蒂扭转的超声表现及诊断价值[J/OL]. 中华医学超声杂志(电子版), 2025, 22(08): 748-753.
[7] 刘晴晴, 俞劲, 徐玮泽, 张志伟, 潘晓华, 舒强, 叶菁菁. OBICnet图像分类模型在小儿先天性心脏病超声筛查中的应用价值[J/OL]. 中华医学超声杂志(电子版), 2025, 22(08): 754-760.
[8] 杨秀玲, 王文辉, 杨婕, 卢强. 双表型肝细胞癌与经典型肝细胞癌超声造影特征及危险因素分析[J/OL]. 中华医学超声杂志(电子版), 2025, 22(08): 761-767.
[9] 张俊清, 周秘, 张文军, 谭静, 尹立雪. 射血分数保留肝硬化患者的肝脏硬度与左心室功能超声特征及相关性分析[J/OL]. 中华医学超声杂志(电子版), 2025, 22(08): 768-776.
[10] 高思琦, 张博闻, 蒋天安. 多模态声像图特征预测IgG4相关性胰腺炎应用类固醇类药物后影像学缓解与急性发作[J/OL]. 中华医学超声杂志(电子版), 2025, 22(07): 592-599.
[11] 高瑞霞, 韩佳豪, 宋丹蕾, 王萍萍, 李嘉. 三种超声技术对超重人群肝脂肪变性诊断性能的评估和比较[J/OL]. 中华医学超声杂志(电子版), 2025, 22(07): 600-607.
[12] 薛小伟, 张超, 杨振娟, 闫亚妮, 李云桃, 裴秋艳. 胎儿无顶冠状静脉窦的解剖学习及超声诊断方法[J/OL]. 中华医学超声杂志(电子版), 2025, 22(07): 608-613.
[13] 颜华伦, 壮健, 朱韦文, 张超, 赵彤, 贾中芝. 肌骨超声联合剪切波弹性成像在不同类型肩袖撕裂术后评估中的临床应用[J/OL]. 中华医学超声杂志(电子版), 2025, 22(06): 527-534.
[14] 王毅, 孔剑桥, 张鹏, 代扬, 李恒平. 腹腔镜超声引导十二指肠镜治疗胆囊合并胆总管结石[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(06): 658-661.
[15] 孟竹达, 靳亚杰, 郝冉, 赵二鹏. MMIF与围手术期指标预测甲状腺全切术后甲状旁腺功能减退的价值[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(06): 678-681.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?