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中华医学超声杂志(电子版) ›› 2025, Vol. 22 ›› Issue (08) : 733 -739. doi: 10.3877/cma.j.issn.1672-6448.2025.08.007

妇产科超声影像学

妊娠期卵巢子宫内膜异位囊肿蜕膜化的临床及超声影像学特征
康林立1,2, 陈璐1, 张天歌1, 刘勤1, 汪龙霞1,()   
  1. 1 100853 北京,解放军总医院第一医学中心超声诊断科
    2 215001 苏州,南京医科大学附属苏州医院超声中心
  • 收稿日期:2025-03-27 出版日期:2025-08-01
  • 通信作者: 汪龙霞

Clinical and ultrasound characteristics of decidualized ovarian endometrioma during pregnancy

Linli Kang1,2, Lu Chen1, Tiange Zhang1, Qin Liu1, Longxia Wang1,()   

  1. 1 Department of Ultrasound, General Hospital of the PLA, Beijing 100853, China
    2 Ultrasound Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215001, China
  • Received:2025-03-27 Published:2025-08-01
  • Corresponding author: Longxia Wang
引用本文:

康林立, 陈璐, 张天歌, 刘勤, 汪龙霞. 妊娠期卵巢子宫内膜异位囊肿蜕膜化的临床及超声影像学特征[J/OL]. 中华医学超声杂志(电子版), 2025, 22(08): 733-739.

Linli Kang, Lu Chen, Tiange Zhang, Qin Liu, Longxia Wang. Clinical and ultrasound characteristics of decidualized ovarian endometrioma during pregnancy[J/OL]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2025, 22(08): 733-739.

目的

分析和总结妊娠期卵巢子宫内膜异位囊肿蜕膜化的临床特征及超声影像学表现,为临床诊疗提供参考依据。

方法

回顾性分析2021年7月至 2024年11月期间11例在解放军总医院第一医学中心临床诊断为妊娠期卵巢子宫内膜异位囊肿蜕膜化患者的病历资料,包括患者的临床资料、超声图像特征、随访记录及手术病理结果。总结妊娠期卵巢子宫内膜异位囊肿蜕膜化的超声特征和临床鉴别诊断要点。

结果

所有患者超声检查均提示妊娠期伴卵巢囊肿。囊肿最大直径为3.1~7.3 cm,90.9%(10/11)的患者囊内液透声差,乳头个数为1~6个不等;彩色多普勒血流成像示10例乳头状突起内可见血流信号,1例乳头状突起内未见血流信号,72.7%(8/11)血流评分以2~3分为主;8例(72.7%,8/11)子宫滑动征阴性。3例行手术切除治疗,术后病理诊断为卵巢子宫内膜异位囊肿,间质蜕膜样变;8例于超声随诊过程中乳头消失,其中1例产后1年因囊肿破裂经手术后病理证实为卵巢子宫内膜异位囊肿,另2例流产后及5例妊娠后超声复诊发现囊肿形态学改变,结合临床资料,诊断为卵巢子宫内膜异位囊肿蜕膜化。

结论

妊娠期卵巢子宫内膜异位囊肿蜕膜化具有特征性超声表现,结合临床特征及随访变化可提高诊断准确性,避免不必要的手术干预。建议对可疑病例采取动态随访观察的管理策略。

Objective

To analyze and summarize the clinical characteristics and ultrasonographic features of decidualized ovarian endometrioma (DOE) during pregnancy to provide a reference for its clinical diagnosis and treatment.

Methods

A retrospective analysis was conducted on the medical records of 11 patients clinically diagnosed with DOE during pregnancy at the General Hospital of the PLA from July 2021 to November 2024. The data included clinical information, ultrasound images, follow-up records, and surgical pathological results. The ultrasonographic characteristics and key points for clinical diagnosis and differentiation of DOE during pregnancy were summarized.

Results

All patients exhibited ovarian cysts during pregnancy on ultrasound. The largest diameter of the endometriomas ranged from 3.1 to 7.3 cm, 90.9% (10/11) showed poor echogenicity of intracystic fluid, and the number of papillary projections ranged from 1-6 per cyst. Color Doppler flow imaging detected blood flow signals in 10 cases (flow scores: 2-3 in 72.7% [8/11]), and 72.7% (8/11) had a negative "sliding uterus sign". Three patients underwent surgical resection and had histologically confirmed benign DOE. Sign of decidualization disappeared in 8 cases during the follow-up period. Among these, one case had histologically confirmed benign DOE after surgery due to cyst rupture one year after pregnancy, The remaining 2 cases after abortion and 5 cases during pregnancy showed morphological changes in the cysts in the follow-up period, leading to a diagnosis of DOE based on clinical data.

Conclusion

DOE during pregnancy exhibits characteristic ultrasonographic features. Combining clinical characteristics and follow-up changes can improve diagnostic accuracy and avoid unnecessary surgical intervention. A dynamic follow-up observation strategy is recommended for suspected cases.

表1 11例OEM患者超声检查结果及临床结局
例序 年龄(岁) 诊断妊娠天数(d) 最大囊肿大小(cm×cm×cm) 囊肿侧别 囊内液透声 囊肿类型 最大囊肿乳头个数 乳头表面 最大乳头大小(cm×cm) 乳头血流评分 有无OEM病史 CA125(U/ml) 子宫滑动征 超声提示 结局 病理
1 29 38 6.9×5.2×6.4 单侧 单房 3 光滑 1.6×0.8 2 125.6 阴性 囊腺瘤不除外 孕期随访乳头未消失,剖宫产+囊肿剥除术 子宫内膜异位囊肿,间质蜕膜样变
2 28 44 7.3×5.8×6.8 双侧 多房 4~6 光滑 1.2×0.9 3 467.3 阴性 性质待定 孕9周自然流产后随访乳头消失 未手术
3 36 59 5.4×4.4×6.0 双侧 多房 3 光滑 1.6×1.2 3 不详 55.9 阴性 囊腺瘤不除外 孕10周行人工流产术,后随访乳头消失 未手术
4 46 56 3.3×2.7×2.5 单侧 多房 1 光滑 0.5×0.3 2 - 阳性 囊腺瘤不除外 随访乳头消失 未手术
5 28 40 3.2×2.9×2.7 单侧 欠佳 多房 1 光滑 1.1×0.6 3 不详 108.6 阳性 性质待定,囊腺瘤? 随访乳头消失 未手术
6 29 42 3.8×2.9×3.0 单侧 多房 3~5 光滑 1.2×1.2 4 不详 65.9 阴性 性质待定,请结合肿瘤标志物检查 14+2周行卵巢囊肿剥除术 子宫内膜异位囊肿,间质蜕膜样变
7 37 63 6.2×3.8×5.5 单侧 尚可 多房 1 光滑 1.3×0.3 1 - 阴性 良性可能性大 2 d后随访乳头消失,剖宫产+左侧卵巢囊肿剥除术 子宫内膜异位囊肿,部分间质蜕膜样变
8 29 44 7.0×4.4×4.3 双侧 单房 1 光滑 1.3×0.9 2 - 阴性 OEM不除外 随访乳头消失 未手术
9 28 53 3.1×2.1×2.1 单侧 单房 2~3 光滑 1.5×1.2 2 - 阳性 OEM不除外 随访乳头消失 未手术
10 34 45 6.9×3.6×4.8 双侧 多房 2 光滑 3.5×1.5 4 250.2 阴性 OEM可能性大 随访乳头消失,产后1年OEM破裂出血行腹腔镜手术 子宫内膜异位囊肿
11 33 49 4.8×3.1×4.1 单侧 单房 2~3 光滑 0.7×0.4 2 不详 - 阴性 OEM不除外 随访乳头消失 未手术
图1 停经38 d,右侧附件肿块经阴道超声图像。图a为灰阶超声显示右侧卵巢一囊性为主的混合回声(箭头示囊内实性乳头状突起);图b为彩色多普勒超声显示囊内实性乳头状突起内可见少许血流信号(箭头示囊内实性乳头状突起处血流信号);图c为病理示卵巢子宫内膜异位囊肿并间质蜕膜化(HE ×200)
图2 停经44 d,左侧附件肿块经阴道超声图像。图a为灰阶超声显示左侧卵巢一囊性为主的混合回声(箭头示囊内实性乳头状突起);图b为彩色多普勒超声显示囊内实性乳头状突起内可见少许血流信号(箭头所示);图c为自然流产术后12 d超声造影显示实性乳头状突起为等增强(箭头所示)
图3 停经42d,右侧附件肿块经阴道超声图像。图a为灰阶超声显示右侧卵巢一囊性为主的混合回声(箭头示囊内实性乳头状突起);图b为彩色多普勒超声显示囊内实性乳头状突起内可见少许血流信号(箭头示囊内实性乳头状突起处血流信号);图c为病理示卵巢子宫内膜异位囊肿并间质蜕膜化(HE ×200)
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